Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:1255-1261
Published online before print May 29, 2003, doi: 10.1161/01.ATV.0000079512.66448.1D
Published online before print May 29, 2003, doi: 10.1161/01.ATV.0000079512.66448.1D
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2003 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
C-Reactive Protein, Interleukin-6, and Fibrinogen as Predictors of Coronary Heart Disease
The PRIME Study
From the Department of Atherosclerosis (G.L., J.-C.F.), SERLIA-INSERM UR545, Institut Pasteur de Lille and University Lille II, France; U.F.R. of Pharmacy (J.-M.B.), INSERM UR539, Nantes, France; Department of Hematology (I.J.-V.), Hôpital de la Timone, Marseille, France; Toulouse MONICA Project (J.F.), INSERM U588, Department of Epidemiology, Paul Sabatier-Toulouse Purpan University, Toulouse, France; Department of Epidemiology and Public Health (A.E.), Queen’s University Belfast, Northern Ireland; Lille Monica Project (P.A.), INSERM U508, Pasteur Institute of Lille, France; Strasbourg MONICA Project (D.A.), Department of Epidemiology and Public Health, Faculty of Medicine, Strasbourg, France; and Coordinating Center (P.D.), INSERM U258, Hôpital Paul Brousse, Villejuif, France.
Correspondence to Gérald Luc, Department of Atherosclerosis, SERLIA-INSERM UR545, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, 59019 Lille Cedex, France. E-mail Gerald.Luc{at}pasteur-lille.fr
Objective— This study was undertaken to examine the association of plasma inflammatory markers such as C-reactive protein (CRP), interleukin-6, and fibrinogen with the incidence of coronary heart disease within the prospective cohort study on myocardial infarction (PRIME study).
Methods and Results— Multiple risk factors were recorded at baseline in 9758 men aged 50 to 59 years who were free of coronary heart disease (CHD) on entry. Nested case-control comparisons were carried out on 317 participants who suffered myocardial infarction (MI)-coronary death (n=163) or angina (n=158) as an initial CHD event during a follow-up for 5 years. After adjustment for traditional risk factors, incident MI-coronary death, but not angina, was significantly associated with CRP, interleukin-6, and fibrinogen, but only interleukin-6 remained significantly associated with MI-coronary death when the 3 inflammatory markers were included in the model. The different interleukin-6 levels in Northern Ireland and France partly explained the difference in risk between these countries. Interleukin-6 appeared as a risk marker of MI-coronary death, and it improved the definition of CHD risk beyond LDL cholesterol.
Conclusions— This association may reflect the underlying inflammatory reaction located in the atherosclerotic plaque or a genetic susceptibility on the part of CHD subjects to answer a proinflammatory stimulus and subsequent increase in hepatic CRP gene expression.
Key Words: coronary heart disease • C-reactive protein • interleukin-6 • fibrinogen
This article has been cited by other articles:
 |
|
 |
|
  W. T. McNicholas Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea: Overlaps in Pathophysiology, Systemic Inflammation, and Cardiovascular Disease Am. J. Respir. Crit. Care Med., October 15, 2009; 180(8): 692 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. I. Buckley, R. Fu, M. Freeman, K. Rogers, and M. Helfand C-Reactive Protein as a Risk Factor for Coronary Heart Disease: A Systematic Review and Meta-analyses for the U.S. Preventive Services Task Force Ann Intern Med, October 6, 2009; 151(7): 483 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Helfand, D. I. Buckley, M. Freeman, R. Fu, K. Rogers, C. Fleming, and L. L. Humphrey Emerging Risk Factors for Coronary Heart Disease: A Summary of Systematic Reviews Conducted for the U.S. Preventive Services Task Force Ann Intern Med, October 6, 2009; 151(7): 496 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Keller, R. Katz, M. J. Sarnak, L. F. Fried, B. Kestenbaum, M. Cushman, M. G. Shlipak, and for the CHS study Inflammatory biomarkers and decline in kidney function in the elderly: the Cardiovascular Health Study Nephrol. Dial. Transplant., September 3, 2009; (2009) gfp429v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Elliott, J. C. Chambers, W. Zhang, R. Clarke, J. C. Hopewell, J. F. Peden, J. Erdmann, P. Braund, J. C. Engert, D. Bennett, et al. Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease JAMA, July 1, 2009; 302(1): 37 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Huang, D. Kempuraj, N. Papadopoulou, T. Kourelis, J. Donelan, A. Manola, and T. C Theoharides Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-{kappa}B activation J. Mol. Endocrinol., May 1, 2009; 42(5): 397 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Hingorani, T. Shah, J. P. Casas, S. E. Humphries, and P. J. Talmud C-Reactive Protein and Coronary Heart Disease: Predictive Test or Therapeutic Target? Clin. Chem., February 1, 2009; 55(2): 239 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. MacNee, J. Maclay, and D. McAllister Cardiovascular Injury and Repair in Chronic Obstructive Pulmonary Disease Proceedings of the ATS, December 1, 2008; 5(8): 824 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Empana, F. Canoui-Poitrine, G. Luc, I. Juhan-Vague, P. Morange, D. Arveiler, J. Ferrieres, P. Amouyel, A. Bingham, M. Montaye, et al. Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study Eur. Heart J., August 2, 2008; 29(16): 1966 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Arima, M. Kubo, K. Yonemoto, Y. Doi, T. Ninomiya, Y. Tanizaki, J. Hata, K. Matsumura, M. Iida, and Y. Kiyohara High-Sensitivity C-Reactive Protein and Coronary Heart Disease in a General Population of Japanese: The Hisayama Study Arterioscler Thromb Vasc Biol, July 1, 2008; 28(7): 1385 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nabi, A. Singh-Manoux, M. Shipley, D. Gimeno, M. G. Marmot, and M. Kivimaki Do Psychological Factors Affect Inflammation and Incident Coronary Heart Disease: The Whitehall II Study Arterioscler Thromb Vasc Biol, July 1, 2008; 28(7): 1398 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Koenig, N. Khuseyinova, J. Baumert, and C. Meisinger Prospective Study of High-Sensitivity C-Reactive Protein as a Determinant of Mortality: Results from the MONICA/KORA Augsburg Cohort Study, 1984-1998 Clin. Chem., February 1, 2008; 54(2): 335 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Stewart, D. Janicki-Deverts, M. F. Muldoon, and T. W. Kamarck Depressive Symptoms Moderate the Influence of Hostility on Serum Interleukin-6 and C-Reactive Protein Psychosom Med, February 1, 2008; 70(2): 197 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Novaro, R. Katz, R. J. Aviles, J. S. Gottdiener, M. Cushman, B. M. Psaty, C. M. Otto, and B. P. Griffin Clinical Factors, But Not C-Reactive Protein, Predict Progression of Calcific Aortic-Valve Disease: The Cardiovascular Health Study J. Am. Coll. Cardiol., November 13, 2007; 50(20): 1992 - 1998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Tzoulaki, G. D. Murray, A. J. Lee, A. Rumley, G. D.O. Lowe, and F. G. R. Fowkes Relative Value of Inflammatory, Hemostatic, and Rheological Factors for Incident Myocardial Infarction and Stroke: The Edinburgh Artery Study Circulation, April 24, 2007; 115(16): 2119 - 2127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Sinning, C. Bickel, C.-M. Messow, R. Schnabel, E. Lubos, H. J. Rupprecht, C. Espinola-Klein, K. J. Lackner, L. Tiret, T. Munzel, et al. Impact of C-reactive protein and fibrinogen on cardiovascular prognosis in patients with stable angina pectoris: the AtheroGene study Eur. Heart J., December 2, 2006; 27(24): 2962 - 2968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Koenig, N. Khuseyinova, J. Baumert, B. Thorand, H. Loewel, L. Chambless, C. Meisinger, A. Schneider, S. Martin, H. Kolb, et al. Increased Concentrations of C-Reactive Protein and IL-6 but not IL-18 Are Independently Associated With Incident Coronary Events in Middle-Aged Men and Women: Results From the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002 Arterioscler Thromb Vasc Biol, December 1, 2006; 26(12): 2745 - 2751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Marsland, K. L. Petersen, R. Sathanoori, M. F. Muldoon, S. A. Neumann, C. Ryan, J. D. Flory, and S. B. Manuck Interleukin-6 Covaries Inversely With Cognitive Performance Among Middle-Aged Community Volunteers Psychosom Med, November 1, 2006; 68(6): 895 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mehra, A. Storfer-Isser, H. L. Kirchner, N. Johnson, N. Jenny, R. P. Tracy, and S. Redline Soluble interleukin 6 receptor: a novel marker of moderate to severe sleep-related breathing disorder. Arch Intern Med, September 18, 2006; 166(16): 1725 - 1731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yilmaz, J. Weber, I. Cicha, C. Stumpf, M. Klein, D. Raithel, W. G. Daniel, and C. D. Garlichs Decrease in Circulating Myeloid Dendritic Cell Precursors in Coronary Artery Disease J. Am. Coll. Cardiol., July 4, 2006; 48(1): 70 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Langenberg, J. Bergstrom, C. Scheidt-Nave, J. Pfeilschifter, and E. Barrett-Connor Cardiovascular Death and the Metabolic Syndrome: Role of adiposity-signaling hormones and inflammatory markers. Diabetes Care, June 1, 2006; 29(6): 1363 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Vasan Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations Circulation, May 16, 2006; 113(19): 2335 - 2362. [Full Text] [PDF]
|
|
|
|
 |
|
 L. K. Summers Adipose tissue metabolism, diabetes and vascular disease -- lessons from in vivo studies Diabetes and Vascular Disease Research, May 1, 2006; 3(1): 12 - 21. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Jiang, D. R. Jacobs Jr., E. Mayer-Davis, M. Szklo, D. Herrington, N. S. Jenny, R. Kronmal, and R. G. Barr Nut and Seed Consumption and Inflammatory Markers in the Multi-Ethnic Study of Atherosclerosis Am. J. Epidemiol., February 1, 2006; 163(3): 222 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M Carter Inflammation, thrombosis and acute coronary syndromes Diabetes and Vascular Disease Research, October 1, 2005; 2(3): 113 - 121. [Abstract] [PDF]
|
|
|
|
 |
|
 T. T Fung, M. L McCullough, P. Newby, J. E Manson, J. B Meigs, N. Rifai, W. C Willett, and F. B Hu Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction Am. J. Clinical Nutrition, July 1, 2005; 82(1): 163 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.P. Empana, D.H. Sykes, G. Luc, I. Juhan-Vague, D. Arveiler, J. Ferrieres, P. Amouyel, A. Bingham, M. Montaye, J.B. Ruidavets, et al. Contributions of Depressive Mood and Circulating Inflammatory Markers to Coronary Heart Disease in Healthy European Men: The Prospective Epidemiological Study of Myocardial Infarction (PRIME) Circulation, May 10, 2005; 111(18): 2299 - 2305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Kritchevsky, M. Cesari, and M. Pahor Inflammatory markers and cardiovascular health in older adults Cardiovasc Res, May 1, 2005; 66(2): 265 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Stuveling, S. J. L. Bakker, H. L. Hillege, P. E. de Jong, R. O. B. Gans, and D. de Zeeuw Biochemical risk markers: a novel area for better prediction of renal risk? Nephrol. Dial. Transplant., March 1, 2005; 20(3): 497 - 508. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Weger, I. Steinbrugger, A. Haas, W. Marz, Y. El-Shabrawi, W. Weger, O. Schmut, and W. Renner Role of the Interleukin-6 -174 G>C Gene Polymorphism in Retinal Artery Occlusion Stroke, February 1, 2005; 36(2): 249 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Vgontzas, E. Zoumakis, E. O. Bixler, H.-M. Lin, H. Follett, A. Kales, and G. P. Chrousos Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2119 - 2126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.E. Morange, C. Simon, M.C. Alessi, G. Luc, D. Arveiler, J. Ferrieres, P. Amouyel, A. Evans, P. Ducimetiere, I. Juhan-Vague, et al. Endothelial Cell Markers and the Risk of Coronary Heart Disease: The Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study Circulation, March 23, 2004; 109(11): 1343 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Blankenberg, G. Luc, P. Ducimetiere, D. Arveiler, J. Ferrieres, P. Amouyel, A. Evans, F. Cambien, L. Tiret, and on behalf of the PRIME Study Group Interleukin-18 and the Risk of Coronary Heart Disease in European Men: The Prospective Epidemiological Study of Myocardial Infarction (PRIME) Circulation, November 18, 2003; 108(20): 2453 - 2459. [Abstract] [Full Text] [PDF]
|
|