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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:1161.)
© 2003 American Heart Association, Inc.

ATVB In Focus

Caveolin, Caveolae, and Endothelial Cell Function

Philippe G. Frank; Scott E. Woodman; David S. Park; Michael P. Lisanti

From the Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY.

Correspondence to Michael P. Lisanti, Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding 202, Bronx, NY 10461. E-mail lisanti{at}aecom.yu.edu

Caveolae are 50- to 100-nm cell-surface plasma membrane invaginations observed in terminally differentiated cells. They are particularly abundant in endothelial cells, where they are believed to play a major role in the regulation of endothelial vesicular trafficking and signal transduction. The use of caveolin-1–deficient mice has provided many new insights into the roles of caveolae and caveolin-1 in the regulation of endothelial cell function. These novel findings suggest an important role for caveolin-1 in the pathogenesis of cancer, atherosclerosis, and vascular disease.

Key Words: caveolae • endothelial cells • transcytosis • angiogenesis • atherosclerosis

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