Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:953-964
Published online before print April 10, 2003, doi: 10.1161/01.ATV.0000071347.69358.D9
Published online before print April 10, 2003, doi: 10.1161/01.ATV.0000071347.69358.D9
© 2003 American Heart Association, Inc.
ATVB in Focus |
Signal Transduction Pathways Mediated by PECAM-1
New Roles for an Old Molecule in Platelet and Vascular Cell Biology
From the Blood Research Institute, The Blood Center of Southeastern Wisconsin (P.J.N., D.K.N.), and the Departments of Pharmacology (P.J.N.), Cellular Biology (P.J.N.), and Microbiology (D.K.N.) and Cardiovascular Center (P.J.N.), Medical College of Wisconsin, Milwaukee, Wis.
Correspondence to Peter J. Newman, Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N. 18th St, Milwaukee, WI 53201. E-mail pjnewman{at}bcsew.edu
Series Editor: Lawrence Brass
ATVB In Focus Platelet Activation and the Formation of the Platelet Plug
Previous Brief Reviews in this Series:
•Tsai H-M. Deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura. 2003;23:388–396.
•Quinn MJ, Byzova TV, Qin J, Topol EJ, Plow EF. Integrin 
IIbß3 and its antagonism. 2003;23:945–952.
Recent studies of platelet endothelial cell adhesion molecule-1 (PECAM-1 [CD31])-deficient mice have revealed that this molecule plays an important role in controlling the activation and survival of cells on which it is expressed. In this review, we focus on the complex cytoplasmic domain of PECAM-1 and describe what is presently known about its structure, posttranslational modifications, and binding partners. In addition, we summarize findings that implicate PECAM-1 as an inhibitor of cellular activation via protein tyrosine kinase–dependent signaling pathways, an activator of integrins, and a suppressor of cell death via pathways that depend on damage to the mitochondria. The challenge of future research will be to bridge our understanding of the functional and biochemical properties of PECAM-1 by establishing mechanistic links between signals transduced by the PECAM-1 cytoplasmic domain and discrete cellular responses.
Key Words: PECAM-1 • signal transduction • ITIM • SHP-2 • alternative splicing
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