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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:940.)
© 2003 American Heart Association, Inc.

ATVB in Focus

Human Protease-Activated Receptor 1 Expression in Malignant Epithelia

A Role in Invasiveness

Yong-Jun Yin; Zaidoun Salah; Sorina Grisaru-Granovsky; Irit Cohen; Sharona Cohen Even-Ram; Myriam Maoz; Beatrice Uziely; Tamar Peretz; Rachel Bar-Shavit

From the Department of Oncology Hadassah-University Hospital, Jerusalem, Israel.

Correspondence to Rachel Bar-Shavit, PhD, Department of Oncology, Hadassah-University Hospital, POB 12000, Jerusalem 91120, Israel. E-mail barshav{at}md.huji.ac.il

Series Editor: Marschall S. Runge
ATVB In Focus Extracellular Mediators in Atherosclerosis and Thrombosis

Previous Brief Reviews in this Series:

•Brasier AR, Recinos A III, Eledrisi MS. Vascular inflammation and the renin-angiotensin system. 2002;22:1257–1266.
•Moser M, Patterson C. Thrombin and vascular development: a sticky subject. 2003;23:922–930.
•Major CD, Santulli RJ, Derian CK, Andrade-Gordon P. Extracellular mediators in atherosclerosis and thrombosis: lessons from thrombin receptor knockout mice. 2003;23:931–939.

While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.

Key Words: PAR1 • epithelia • invasion • metastasis • angiogenesis

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