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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:912.)
© 2003 American Heart Association, Inc.

Letters to the Editor

Confirmation of the Microsomal Triglyceride Transfer Protein Genetic Effect on Lipids in Young African American Men From the CARDIA Study

Suh-Hang Hank Juo; Laura Colangelo; Zhihua Han; Jonathan D. Smith; Kiang Liu

Genome Center (S.-H.H.J.) and Department of Epidemiology (S.-H.H.J.), Columbia University, New York, NY; Laboratory of Biochemical Genetics and Metabolism (Z.H., J.D.S.), Rockefeller University, New York, NY; and Department of Preventive Medicine (L.C., K.L.), Northwestern University, Chicago, Ill

An extract of the first 250 words of the full text is provided, because this article has no abstract.

To the Editor:

We previously studied the association between the -493 G/T polymorphism of the microsomal triglyceride transfer protein (MTP) gene and the lipid profile in young African American men from the CARDIA cohort.¹ The total cholesterol and LDL cholesterol (LDL-C) levels were significantly higher in the TT genotype in the first 4 consecutive measures between 1985 and 1993, but not in the 5th measure in 1996. We analyzed the new data measured in 2001 from the same cohort to test whether the nonsignificant result in the 5th measure is due to diminished genetic effect with age or random variation of data.

The results from analysis of the 6th measure in 2001 showed a significant genetic effect, confirming the influence of the MTP promoter polymorphism in this cohort. Total cholesterol, LDL-C, and nonHDL-C (ie, total cholesterol minus HDL-C) in the TT genotype are higher than in the other two genotypes in the year 2001 data, which is consistent with results from the 1st to 4th measures (Table). The present results suggested that the nonsignificant results in the 5th data were more likely to be due to random variation. The TT genotype was associated with higher levels (mg/dL) of total cholesterol ranging from 2 to 19, LDL-C ranging from 9 to 17 (no difference in the 5th measure), and nonHDL-C ranging from 2 to 19 (Table). Longitudinal analysis by the generalized estimating equation (GEE) model^2,3 revealed no evidence of interaction between genotype and time: the coefficients were . . . [Full Text of this Article]