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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1506.)
© 2002 American Heart Association, Inc.

In Memoriam

Donald S. Fredrickson, MD

1924–2002

Antonio M. Gotto, Jr

From Weill Medical College of Cornell University, New York.

Correspondence to Antonio M. Gotto, Jr, MD, DPhil, Dean, Weill Medical College of Cornell University, c/o Paula Trushin, Olin Hall, Room 205, 445 East 69th St, New York, NY 10021. E-mail pat2004@med.cornell.edu

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Dr Donald S. Fredrickson (Figure), who died on June 7, 2002, was an internationally recognized authority on disorders of lipid metabolism and, in the words of National Institutes of Health (NIH) director Elias Zerhouni, "a towering influence in the scientific community"¹ (personal communication, NIH, July 23, 2002). In the past half century, Dr Fredrickson’s accomplishments in basic science, clinical investigation, and public service transformed the field of cardiovascular medicine and advanced the conduct of research. But Don Fredrickson is also the man who, in 1965, first invited me to work with him and Dr Robert I. Levy in the Molecular Disease Branch of the NIH. This marked the beginning of my research career. With the death of Don Fredrickson, an era has ended, and we who knew him have lost a friend and colleague.

View larger version (139K): [in this window] [in a new window]   Donald S. Fredrickson, MD; photo courtesy of NIH.

Don’s accomplishments in science and medicine helped create the field of lipidology, an entirely new discipline. His earliest research interests focused on sterol metabolism. Subsequently, he concentrated on the structure and metabolism of the plasma lipoproteins, their role in transporting fats, and the genetic factors regulating their metabolism and concentration in the blood (personal communication, NIH, July 23, 2002). At the Molecular Disease Branch of the NIH, which he headed from 1966 to 1974, Don and his colleagues were involved in discoveries that included separating apolipoproteins A, B, and C into their component parts and characterizing and sequencing apolipoproteins A-II, C-I, C-II, and C-III.^2–9 In addition, . . . [Full Text of this Article]