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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1465.)
© 2002 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Relationship Between Cholesteryl Ester Transfer Protein and Atherogenic Lipoprotein Profile in Morbidly Obese Women

C.F. Ebenbichler; M. Laimer; S. Kaser; A. Ritsch; A. Sandhofer; H. Weiss; F. Aigner; J.R. Patsch

From the Universitätsklinik für Innere Medizin (C.F.E., M.L., S.K., A.R., A.S., J.R.P.), Universität Innsbruck, Austria, and Universitätsklinik für Chirurgie (H.W., F.A.), Universität Innsbruck, Innsbruck, Austria.

Correspondence to Christoph F. Ebenbichler, MD, Universitätsklinik für Innere Medizin, Universität Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. E-mail Christoph.Ebenbichler{at}uibk.ac.at

Objective— Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Lipid abnormalities contribute to the increased relative risk in obese subjects. Cholesteryl ester transfer protein (CETP) mass is increased in these patients and might mediate the atherogenic lipoprotein pattern observed in obesity.

Methods and Results— Twenty-one morbidly obese, middle-aged, female subjects participated in this prospective study. Subjects were examined before and 1 year after surgical treatment. Fat mass was determined by body impedance analysis; CETP mass, by ELISA; CETP activity, by exogenous substrate assay; and LDL particle diameter, by gradient gel electrophoresis. Mean weight loss after 1 year was 28.7 kg; mean fat mass loss was 22.6 kg. Mean CETP mass decreased from 1.81 to 1.32 µg/mL (P=0.008); mean CETP activity decreased from 244 to 184 nmol · mL^-1 · h^-1 (P=0.004); and in parallel, the mean diameter of LDL particles increased (256.8 to 258.4 Å, P=0.04).

Conclusions— We conclude that weight loss is associated with a pronounced decrease in CETP mass and activity and a consistent increase in LDL particle diameter. After 1 year of this prospective study in morbidly obese subjects undergoing weight loss by surgical treatment, it has been determined that some features of the atherogenic lipoprotein profile can be reversed.

Key Words: obesity • gastric banding • lipids • cholesteryl ester transfer protein

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