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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1390.)
© 2002 American Heart Association, Inc.

Brief Reviews

Quantitative Trait Loci and Candidate Genes Regulating HDL Cholesterol

A Murine Chromosome Map

Xiaosong Wang; Beverly Paigen

From The Jackson Laboratory, Bar Harbor, Me.

Correspondence to Beverly Paigen, PhD, The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609. E-mail bjp{at}jax.org

Objective— Summarizing the many discovered mouse and human quantitative trait loci (QTL) for high density lipoprotein (HDL) cholesterol (HDL-C) levels is important for guiding future research on the genetic regulation of HDL concentrations and for finding gene targets for upregulating HDL levels in mice and humans.

Methods and Results— We summarized the 27 QTL and candidate genes associated with HDL-C concentrations in mice and plotted them on a mouse chromosome map. We also summarized the 22 human QTL for HDL-C levels and compared them with those of the mouse by comparative genomics. At least part of the mouse homologies for 18 of the 22 human HDL-C QTL were within the murine HDL-C QTL.

Conclusions— Murine QTL for HDL-C levels may predict their homologous location in humans, and their underlying genes may be appropriate genes to test in humans.

Key Words: high density lipoproteins • quantitative trait loci • mouse models • cholesterol • atherosclerosis

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