Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1175-1180
Published online before print May 16, 2002, doi: 10.1161/01.ATV.0000022015.97341.3A
Published online before print May 16, 2002, doi: 10.1161/01.ATV.0000022015.97341.3A
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© 2002 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Nuclear Magnetic Resonance Spectroscopy of Lipoproteins and Risk of Coronary Heart Disease in the Cardiovascular Health Study
From the Department of Epidemiology (L.K.), University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa; the CHS Coordinating Center (A.A., D.S., R.K.), Seattle, Wash; the Department of Pathology (R.T.), University of Vermont, Colchester; LipoMed, Inc (J.O.), Raleigh, NC; the Department of Public Health Service (G.B.), Wake Forest University School of Medicine, Winston-Salem, NC; the Cardiovascular Health Research Unit (B.P.), University of Washington, Seattle; and the Division of Nutrition and Physical Activity (D.S.F.), Centers for Disease Control, Atlanta, Ga.
Correspondence to Lewis H. Kuller, MD, DrPH, University of Pittsburgh, GSPH, Department of Epidemiology, 130 DeSoto St, Pittsburgh, PA 15261. E-mail kuller@ pitt.edu
Objectives— Relationships between incident cardiovascular disease and lipoprotein subclass measurements by nuclear magnetic resonance spectroscopy were evaluated in the Cardiovascular Health Study (CHS) in a nested case-cohort analysis.
Methods and Results— The case group consisted of 434 participants with incident myocardial infarction (MI) and angina diagnosed after entry to the study (1990 to 1995) and the comparison group, 249 "healthy" participants with no prevalent clinical or subclinical disease. By univariate analysis, the median levels for healthy participants versus participants with incident MI and angina were 0 versus 7 mg% for small low density lipoprotein (LDL), 1501 versus 1680 nmol/L for the number of LDL particles, and 21.6 versus 21.3 for LDL size, and these values were significantly different between "healthy" participants and those with incident MI and angina for women but not men. The levels of less dense LDL, which is most of the total LDL cholesterol among women, was not related to incident MI and angina. For women, large high density lipoprotein cholesterol (HDLc), but not small HDLc, levels were significantly higher for healthy participants compared with levels for participants with MI and angina. For men and women, levels of total and very low density lipoprotein triglycerides were higher for the case group than for the healthy group. In multivariate models for women that included triglycerides and HDLc, the number of LDL particles (but not LDL size) remained significantly related to MI and angina.
Conclusions— Small LDL, the size of LDL particles, and the greater number of LDL particles are related to incident coronary heart disease among older women.
Key Words: lipoproteins • women • subclinical disease • aging
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