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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1065.)
© 2002 American Heart Association, Inc.

ATVB In Focus

MRI and Characterization of Atherosclerotic Plaque

Emerging Applications and Molecular Imaging

Robin P. Choudhury; Valentin Fuster; Juan J. Badimon; Edward A. Fisher; Zahi A. Fayad

From the Department of Cardiovascular Medicine (R.P.C.), University of Oxford, John Radcliffe Hospital, Oxford, UK, and The Zena and Michael A. Wiener Cardiovascular Institute (V.F., J.J.B., E.A.F., Z.A.F.), Mount Sinai School of Medicine, New York, NY.

Correspondence to Zahi Fayad, PhD, The Cardiovascular Institute, Mount Sinai School of Medicine, Box 1030, 1 Gustave L. Levy Place, New York, NY 10029-6574. E-mail zahi.fayad{at}mssm.edu

Abstract

Noninvasive high-resolution magnetic resonance has the potential to image atherosclerotic plaque and to determine its composition and microanatomy. This review summarizes the rationale for plaque imaging and describes the characteristics of plaque by use of existing MRI techniques. The use of MRI in human disease and in animal models, particularly in rabbits and mice, is presented. Present and future applications of MRI, including real-time vascular intervention, new contrast agents, and molecular imaging, are also discussed.

Key Words: MRI • atherosclerosis • plaque • molecular imaging • mice

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