Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:817-823
Published online before print March 7, 2002, doi: 10.1161/01.ATV.0000014424.18209.21
Published online before print March 7, 2002, doi: 10.1161/01.ATV.0000014424.18209.21
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© 2002 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Association of Estrogen Receptor-
Gene Polymorphisms With Coronary Artery Disease in Patients With Familial Hypercholesterolemia
From Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Correspondence to Toshinori Higashikata, MD, PhD, Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara-machi 13-1, Kanazawa 920-8641, Japan. E-mail hgshkt{at}im2.m.kanazawa-u.ac.jp
To investigate the association of estrogen receptor (ER)-
gene polymorphisms with coronary artery disease (CAD), we studied 197 men and 98 postmenopausal women with heterozygous familial hypercholesterolemia. We examined the known polymorphisms, including PvuII, XbaI, TA repeat, and CA repeat, and identified 6 novel polymorphisms in the ER- gene. The distributions of -1989T/G (a novel polymorphism in promoter B) and XbaI in intron 1 were associated with CAD in postmenopausal women and in men, with a higher frequency of the G/G genotype (P=0.03) or X1/X1 genotype (P=0.02) in the CAD group. The frequency of alleles of TA repeats >17 was found to be significantly higher in postmenopausal women with CAD than in those without CAD (P=0.04), but not in men. Logistic regression analysis with all coronary risk factors as covariates showed that the G/G genotype was a higher risk for CAD (odds ratio 4.5, 95% CI 1.0 to 19.5;P=0.04) but that X1/X1 was not. We conclude that -1989T/G or its linked polymorphisms in the ER- gene may confer risk for CAD and that the G/G genotype may be an independent predictor for CAD in patients with familial hypercholesterolemia.
Key Words: estrogen receptors • polymorphism • promoters • coronary artery disease • hypercholesterolemia
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