This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rosenfeld, M. E. Search for Related Content PubMed PubMed Citation Articles by Rosenfeld, M. E.

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:361.)
© 2002 American Heart Association, Inc.

Editorials

Leukocyte Recruitment Into Developing Atherosclerotic Lesions

The Complex Interaction Between Multiple Molecules Keeps Getting More Complex

Michael E. Rosenfeld

From the Department of Pathobiology, University of Washington, Seattle. E-mail ssmjm@u.washington.edu

Correspondence to Dr. Michael Rosenfeld, Department of Pathobiology, Box 353410, University of Washington, Seattle, WA 98195. E-mail ssmjm@u.washington.edu

Afew years ago, I was asked to give a series of lectures to our second-year medical students on basic inflammatory mechanisms. I was taking the place of the late Russell Ross, who had given these lectures for many years. Among the teaching materials Russ had collected was a videotape generated from a 16-mm movie made in the 1940s. The movie showed leukocytes rolling, adhering, and migrating through capillaries in response to an inflammatory stimulus in a rabbit ear chamber. I used this videotape to illustrate the basic steps in a classical inflammatory response but also to introduce to the students the remarkable complexity of the molecular interactions underlying each step in leukocyte recruitment into inflamed tissues. We have come a long way in delineating the nature of these molecular interactions since the 1940s. We now use in vitro adhesion assays and microscopic techniques such as intravital microscopy, coupled with antibodies and receptor antagonists designed to specify which candidate adhesion molecules, counter receptors, and chemokines mediate leukocyte recruitment^1–7 These have provided a basic molecular paradigm for the rolling, activation, arrest, adhesion, and transmigration of leukocytes. L and P selectins appear to be primarily responsible for the initial capture of cells from the flowing blood, E and P selectins for mediating rolling, and ß2 integrins, ICAM-1, and PECAM-1 for adhesion and transmigration.^8–10 In addition, products of the arachidonate and complement cascades and chemokines, a large family of small peptides that activate leukocytes via binding to G protein–coupled receptors, also seem to play . . . [Full Text of this Article]

This article has been cited by other articles:

				Y.-L. Guo, R. Bai, C. X-J Chen, D.-Q. Liu, Y. Liu, C.-Y. Zhang, and K. Zen Role of Junctional Adhesion Molecule-Like Protein in Mediating Monocyte Transendothelial Migration Arterioscler Thromb Vasc Biol, January 1, 2009; 29(1): 75 - 83. [Abstract] [Full Text] [PDF]

				J. R. Davies, J. H.F. Rudd, P. L. Weissberg, and J. Narula Radionuclide imaging for the detection of inflammation in vulnerable plaques. J. Am. Coll. Cardiol., April 18, 2006; 47(8 Suppl): C57 - C68. [Abstract] [Full Text] [PDF]

				V. Fuster, P. R. Moreno, Z. A. Fayad, R. Corti, and J. J. Badimon Atherothrombosis and High-Risk Plaque: Part I: Evolving Concepts J. Am. Coll. Cardiol., September 20, 2005; 46(6): 937 - 954. [Abstract] [Full Text] [PDF]

				U. Landmesser, B. Hornig, and H. Drexler Endothelial Function: A Critical Determinant in Atherosclerosis? Circulation, June 1, 2004; 109(21_suppl_1): II-27 - II-33. [Abstract] [Full Text] [PDF]

				B. OSTERUD and E. BJORKLID Role of Monocytes in Atherogenesis Physiol Rev, October 1, 2003; 83(4): 1069 - 1112. [Abstract] [Full Text] [PDF]

				T. K. HSIAI, S. K. CHO, P. K. WONG, M. ING, A. SALAZAR, A. SEVANIAN, M. NAVAB, L. L. DEMER, and C.-M. HO Monocyte recruitment to endothelial cells in response to oscillatory shear stress FASEB J, September 1, 2003; 17(12): 1648 - 1657. [Abstract] [Full Text] [PDF]

				T. M. DOHERTY, P. K. SHAH, and T. B. RAJAVASHISTH Cellular origins of atherosclerosis: towards ontogenetic endgame? FASEB J, April 1, 2003; 17(6): 592 - 597. [Full Text] [PDF]

				S. Litovsky, M. Madjid, A. Zarrabi, S. W. Casscells, J. T. Willerson, and M. Naghavi Superparamagnetic Iron Oxide-Based Method for Quantifying Recruitment of Monocytes to Mouse Atherosclerotic Lesions In Vivo: Enhancement by Tissue Necrosis Factor-{alpha}, Interleukin-1{beta}, and Interferon-{gamma} Circulation, March 25, 2003; 107(11): 1545 - 1549. [Abstract] [Full Text] [PDF]