This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Salomaa, V. Articles by Pekkanen, J. Search for Related Content PubMed PubMed Citation Articles by Salomaa, V. Articles by Pekkanen, J. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CHOLESTEROL Related Collections Behavioral/psychosocial - stroke Clinical Studies Acute Cerebral Hemorrhage Coagulation and fibronolysis

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:353.)
© 2002 American Heart Association, Inc.

Thrombosis

Hemostatic Factors as Predictors of Coronary Events and Total Mortality

The FINRISK ’92 Hemostasis Study

Veikko Salomaa; Vesa Rasi; Sangita Kulathinal; Elina Vahtera; Matti Jauhiainen; Christian Ehnholm; Juha Pekkanen

From the Department of Epidemiology and Health Promotion (V.S., S.K.) and the Department of Molecular Medicine (M.J., C.E.), KTL-National Public Health Institute, Helsinki; the Department of Hemostasis (V.R., E.V.), Finnish Red Cross Blood Transfusion Service, Helsinki; and the Unit of Environmental Epidemiology (J.P.), KTL-National Public Health Institute, Kuopio, Finland.

Correspondence to Veikko Salomaa, Department of Epidemiology and Health Promotion, KTL-National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. E-mail veikko.salomaa{at}ktl.fi

The role of hemostatic factors as predictors of coronary heart disease (CHD) and total mortality is poorly understood. Therefore, we carried out a prospective cohort study in Finland. In 1992, a random population sample of 2378 men and women aged 45 to 64 years was investigated and then followed up until December 31, 1998. During the follow-up, 133 CHD events were observed; 73 were among participants free of CHD at baseline. The total number of deaths was 124. After adjustment for traditional risk factors and prevalent CHD at baseline and correction for regression dilution bias, a 1-SD increase in plasminogen was associated with a 1.41-fold (95% CI 1.09 to 1.81) increase in CHD risk. The predictive power of plasminogen depended significantly on the level of total cholesterol being stronger for persons with high cholesterol. A 1-SD increase in fibrinogen was associated with a 1.23-fold (95% CI 1.05 to 1.44) increase in all-cause mortality, but its association with CHD events did not reach statistical significance. Factor VII antigen or coagulant activity or lipoprotein(a) were not independent predictors of CHD risk. These findings support the role of plasminogen as a risk factor for CHD events.

Key Words: hemostatic factors • coronary heart disease • total mortality • fibrinogen • plasminogen

This article has been cited by other articles:

				M. Helfand, D. I. Buckley, M. Freeman, R. Fu, K. Rogers, C. Fleming, and L. L. Humphrey Emerging Risk Factors for Coronary Heart Disease: A Summary of Systematic Reviews Conducted for the U.S. Preventive Services Task Force Ann Intern Med, October 6, 2009; 151(7): 496 - 507. [Abstract] [Full Text] [PDF]

				J. Ahnstrom, O. Axler, M. Jauhiainen, V. Salomaa, A. S. Havulinna, C. Ehnholm, R. Frikke-Schmidt, A. Tybjaerg-Hansen, and B. Dahlback Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies J. Lipid Res., September 1, 2008; 49(9): 1912 - 1917. [Abstract] [Full Text] [PDF]

				P. R. Kamstrup, M. Benn, A. Tybjaerg-Hansen, and B. G. Nordestgaard Extreme Lipoprotein(a) Levels and Risk of Myocardial Infarction in the General Population: The Copenhagen City Heart Study Circulation, January 15, 2008; 117(2): 176 - 184. [Abstract] [Full Text] [PDF]

				Fibrinogen Studies Collaboration* Plasma Fibrinogen Level and the Risk of Major Cardiovascular Diseases and Nonvascular Mortality: An Individual Participant Meta-analysis JAMA, October 12, 2005; 294(14): 1799 - 1809. [Abstract] [Full Text] [PDF]

				V. Fuster, P. R. Moreno, Z. A. Fayad, R. Corti, and J. J. Badimon Atherothrombosis and High-Risk Plaque: Part I: Evolving Concepts J. Am. Coll. Cardiol., September 20, 2005; 46(6): 937 - 954. [Abstract] [Full Text] [PDF]

				J. M. Soria, L. Almasy, J. C. Souto, A. Buil, M. Lathrop, J. Blangero, and J. Fontcuberta A Genome Search for Genetic Determinants That Influence Plasma Fibrinogen Levels Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1287 - 1292. [Abstract] [Full Text] [PDF]

				J. H. Zarifis Atherosclerosis, thrombosis, and inflammatory risk factors, from history and the laboratory to real life Eur. Heart J., February 2, 2005; 26(4): 317 - 318. [Full Text] [PDF]

				K. G. Mann Factor VII-Activating Protease: Coagulation, Fibrinolysis, and Atherothrombosis? Circulation, February 11, 2003; 107(5): 654 - 655. [Full Text] [PDF]