Arteriosclerosis, Thrombosis, and Vascular Biology. 2001;21:961-967
© 2001 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Elevated C-Reactive Protein
Another Component of the Atherothrombotic Profile of Abdominal Obesity
From the Québec Heart Institute (I.L., A.P., N.A., P.B., J.-P.D.), Laval Hospital Research Center; the Lipid Research Center (I.L., A.P., D.P., N.A., J.B., J.-P.D.) and the Diabetes Research Unit (A.N.), CHUL Research Center; and the Division of Kinesiology (D.P.), Faculty of Medicine, Laval University, Ste-Foy, Québec, Canada.
Correspondence to Jean-Pierre Després, PhD, Director of Research, Québec Heart Institute, Laval Hospital Research Center, Pavilion Mallet, 2nd Floor, 2725, chemin Sainte-Foy, Sainte-Foy, Québec G1V 4G5, Canada. E-mail jean-pierre.despres{at}crchul.ulaval.ca
Abstract—Recent studies have suggested that elevated plasma C-reactive protein (CRP) levels are associated with the features of insulin resistance syndrome. In the present study, we have examined the contribution of body composition measured by hydrostatic weighing and of abdominal adipose tissue (AT) accumulation assessed by computed tomography to the variation in plasma CRP levels associated with atherogenic dyslipidemia of the insulin resistance syndrome in a sample of 159 men, aged 22 to 63 years, covering a wide range of adiposity (body mass index values from 21 to 41 kg/m2). Plasma CRP levels showed positive and significant correlations with body fat mass (r=0.41, P<0.0001), waist girth (r=0.37, P<0.0001), and visceral AT accumulation measured by computed tomography at L4 to L5 (r=0.28, P<0.0003). Although CRP levels were associated with plasma insulin levels measured in the fasting state and after a 75-g oral glucose load, no significant correlations were found with plasma lipoprotein levels. Finally, comparison of body fatness, of abdominal fat accumulation, and of the features of the insulin resistance syndrome across quintiles of CRP revealed major differences in body fatness and in indices of abdominal AT accumulation between the lowest and the highest CRP quintiles, whereas no significant differences were found for variables of the plasma lipoprotein-lipid profile. These results suggest that obesity and abdominal AT accumulation are the critical correlates of elevated plasma CRP levels found in men with atherogenic dyslipidemia of the insulin resistance syndrome.
Key Words: C-reactive protein • lipoprotein-lipid profile • glucose-insulin homeostasis • body composition
This article has been cited by other articles:
 |
|
 |
|
  D. I. Buckley, R. Fu, M. Freeman, K. Rogers, and M. Helfand C-Reactive Protein as a Risk Factor for Coronary Heart Disease: A Systematic Review and Meta-analyses for the U.S. Preventive Services Task Force Ann Intern Med, October 6, 2009; 151(7): 483 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sam, S. Haffner, M. H. Davidson, R. B. D'Agostino Sr., S. Feinstein, G. Kondos, A. Perez, and T. Mazzone Hypertriglyceridemic Waist Phenotype Predicts Increased Visceral Fat in Subjects With Type 2 Diabetes Diabetes Care, October 1, 2009; 32(10): 1916 - 1920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cartier, M. Cote, I. Lemieux, L. Perusse, A. Tremblay, C. Bouchard, and J.-P. Despres Sex differences in inflammatory markers: what is the contribution of visceral adiposity? Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1307 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M.-s. Lui, J. C.-m. Lam, H. K.-F. Mak, A. Xu, C. Ooi, D. C.-l. Lam, J. C.-w. Mak, P. L. Khong, and M. S.-M. Ip C-Reactive Protein Is Associated With Obstructive Sleep Apnea Independent of Visceral Obesity Chest, April 1, 2009; 135(4): 950 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Leone, D. Courbon, F. Thomas, K. Bean, B. Jego, B. Leynaert, L. Guize, and M. Zureik Lung Function Impairment and Metabolic Syndrome: The Critical Role of Abdominal Obesity Am. J. Respir. Crit. Care Med., March 15, 2009; 179(6): 509 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bo, L. Corsinovi, A. Brescianini, A. Sona, M. Astengo, R. Dumitrache, M. F. Ferrio, L. Pricop, and G. Fonte High-Sensitivity C-Reactive Protein Is Not Independently Associated With Peripheral Subclinical Atherosclerosis Angiology, February 1, 2009; 60(1): 12 - 20. [Abstract] [PDF]
|
|
|
|
 |
|
 P. G. Wilson, J. C. Thompson, N. R. Webb, F. C. de Beer, V. L. King, and L. R. Tannock Serum Amyloid A, but Not C-Reactive Protein, Stimulates Vascular Proteoglycan Synthesis in a Pro-Atherogenic Manner Am. J. Pathol., December 1, 2008; 173(6): 1902 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ness-Abramof and C. M. Apovian Waist Circumference Measurement in Clinical Practice Nutr Clin Pract, August 1, 2008; 23(4): 397 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Despres, I. Lemieux, J. Bergeron, P. Pibarot, P. Mathieu, E. Larose, J. Rodes-Cabau, O. F. Bertrand, and P. Poirier Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk Arterioscler Thromb Vasc Biol, June 1, 2008; 28(6): 1039 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Subramanian, C. Y. Han, T. Chiba, T. S. McMillen, S. A. Wang, A. Haw III, E. A. Kirk, K. D. O'Brien, and A. Chait Dietary Cholesterol Worsens Adipose Tissue Macrophage Accumulation and Atherosclerosis in Obese LDL Receptor-Deficient Mice Arterioscler Thromb Vasc Biol, April 1, 2008; 28(4): 685 - 691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Despres and H. B. Brewer Metabolic syndrome: the dysmetabolic state of dysfunctional adipose tissue and insulin resistance Eur. Heart J. Suppl., March 1, 2008; 10(suppl_B): B1 - B3. [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Despres, P. Poirier, J. Bergeron, A. Tremblay, I. Lemieux, and N. Almeras From individual risk factors and the metabolic syndrome to global cardiometabolic risk Eur. Heart J. Suppl., March 1, 2008; 10(suppl_B): B24 - B33. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Pou, J. M. Massaro, U. Hoffmann, R. S. Vasan, P. Maurovich-Horvat, M. G. Larson, J. F. Keaney Jr, J. B. Meigs, I. Lipinska, S. Kathiresan, et al. Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress: The Framingham Heart Study Circulation, September 11, 2007; 116(11): 1234 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Lear, K. H. Humphries, S. Kohli, J. J. Frohlich, C. L. Birmingham, and G. B. J. Mancini Visceral Adipose Tissue, a Potential Risk Factor for Carotid Atherosclerosis: Results of the Multicultural Community Health Assessment Trial (M-CHAT) Stroke, September 1, 2007; 38(9): 2422 - 2429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A Lear, K. H Humphries, S. Kohli, A. Chockalingam, J. J Frohlich, and C L. Birmingham Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT) Am. J. Clinical Nutrition, August 1, 2007; 86(2): 353 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, D. P. Belobrajdic, and R. J. Norman C-Reactive Protein before and after Weight Loss in Overweight Women with and without Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 2944 - 2951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Fox, J. M. Massaro, U. Hoffmann, K. M. Pou, P. Maurovich-Horvat, C.-Y. Liu, R. S. Vasan, J. M. Murabito, J. B. Meigs, L. A. Cupples, et al. Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study Circulation, July 3, 2007; 116(1): 39 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Schirmer and S. D. Phinney {gamma}-Linolenate Reduces Weight Regain in Formerly Obese Humans J. Nutr., June 1, 2007; 137(6): 1430 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Ben-Yehuda High-Sensitivity C-Reactive Protein in Every Chart?: The Use of Biomarkers in Individual Patients J. Am. Coll. Cardiol., May 29, 2007; 49(21): 2139 - 2141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Musaad and E. N. Haynes Biomarkers of Obesity and Subsequent Cardiovascular Events Epidemiol. Rev., May 10, 2007; (2007) mxm005v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Matter and C. Handschin RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted), Inflammation, Obesity, and the Metabolic Syndrome Circulation, February 27, 2007; 115(8): 946 - 948. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Blouin, C. Richard, G. Brochu, F.-S. Hould, S. Lebel, S. Marceau, S. Biron, V. Luu-The, and A. Tchernof Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men J. Endocrinol., December 1, 2006; 191(3): 637 - 649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-E. Paradis, K. O. Badellino, D. J. Rader, Y. Deshaies, P. Couture, W. R. Archer, N. Bergeron, and B. Lamarche Endothelial lipase is associated with inflammation in humans J. Lipid Res., December 1, 2006; 47(12): 2808 - 2813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Aeberli, L. Molinari, G. Spinas, R. Lehmann, D. l'Allemand, and M. B Zimmermann Dietary intakes of fat and antioxidant vitamins are predictors of subclinical inflammation in overweight Swiss children. Am. J. Clinical Nutrition, October 1, 2006; 84(4): 748 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Briand, I. Lemieux, J. G. Dumesnil, P. Mathieu, A. Cartier, J.-P. Despres, M. Arsenault, J. Couet, and P. Pibarot Metabolic Syndrome Negatively Influences Disease Progression and Prognosis in Aortic Stenosis J. Am. Coll. Cardiol., June 6, 2006; 47(11): 2229 - 2236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Despres Abdominal obesity: the most prevalent cause of the metabolic syndrome and related cardiometabolic risk Eur. Heart J. Suppl., May 1, 2006; 8(suppl_B): B4 - B12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E Malavazos, E. Cereda, L. Morricone, C. Coman, M. M Corsi, and B. Ambrosi Monocyte chemoattractant protein 1: a possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity Eur. J. Endocrinol., December 1, 2005; 153(6): 871 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Couillard, G. Ruel, W. R. Archer, S. Pomerleau, J. Bergeron, P. Couture, B. Lamarche, and N. Bergeron Circulating Levels of Oxidative Stress Markers and Endothelial Adhesion Molecules in Men with Abdominal Obesity J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6454 - 6459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Despres, A. Golay, L. Sjostrom, and the Rimonabant in Obesity-Lipids Study Group Effects of Rimonabant on Metabolic Risk Factors in Overweight Patients with Dyslipidemia N. Engl. J. Med., November 17, 2005; 353(20): 2121 - 2134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miller, M. Zhan, and S. Havas High Attributable Risk of Elevated C-Reactive Protein Level to Conventional Coronary Heart Disease Risk Factors: The Third National Health and Nutrition Examination Survey Arch Intern Med, October 10, 2005; 165(18): 2063 - 2068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Clearfield C-Reactive Protein: A New Risk Assessment Tool for Cardiovascular Disease J Am Osteopath Assoc, September 1, 2005; 105(9): 409 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. T. Bloomgarden Second World Congress on the Insulin Resistance Syndrome: Mediators, pediatric insulin resistance, the polycystic ovary syndrome, and malignancy Diabetes Care, July 1, 2005; 28(7): 1821 - 1830. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Boschmann, S. Engeli, F. Adams, K. Gorzelniak, G. Franke, S. Klaua, U. Kreuzberg, S. Luedtke, R. Kettritz, A. M. Sharma, et al. Adipose Tissue Metabolism and CD11b Expression on Monocytes in Obese Hypertensives Hypertension, July 1, 2005; 46(1): 130 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Tannock, K. D. O'Brien, R. H. Knopp, B. Retzlaff, B. Fish, M. H. Wener, S. E. Kahn, and A. Chait Cholesterol Feeding Increases C-Reactive Protein and Serum Amyloid A Levels in Lean Insulin-Sensitive Subjects Circulation, June 14, 2005; 111(23): 3058 - 3062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Zieske, R. P. Tracy, C. A. McMahan, E. E. Herderick, S. Homma, G. T. Malcom, H. C. McGill Jr, J. P. Strong, and for the Pathobiological Determinants of Atheroscle Elevated Serum C-Reactive Protein Levels and Advanced Atherosclerosis in Youth Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1237 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Ostberg, M. J. H. Attar, V. Mohamed-Ali, and G. S. Conway Adipokine Dysregulation in Turner Syndrome: Comparison of Circulating Interleukin-6 and Leptin Concentrations with Measures of Adiposity and C-Reactive Protein J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2948 - 2953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tanne, J. H. Medalie, and U. Goldbourt Body Fat Distribution and Long-Term Risk of Stroke Mortality Stroke, May 1, 2005; 36(5): 1021 - 1025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. W. Lau, B. Dhillon, H. Yan, P. E. Szmitko, and S. Verma Adipokines: molecular links between obesity and atheroslcerosis Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2031 - H2041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Nicklas, T. You, and M. Pahor Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training Can. Med. Assoc. J., April 26, 2005; 172(9): 1199 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Takeda, E. Suzuki, H. Satonaka, S. Oba, H. Nishimatsu, M. Omata, T. Fujita, R. Nagai, and Y. Hirata Blockade of Endogenous Cytokines Mitigates Neointimal Formation in Obese Zucker Rats Circulation, March 22, 2005; 111(11): 1398 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Diamant, H. J. Lamb, M. A. van de Ree, E. L. Endert, Y. Groeneveld, M. L. Bots, P. J. Kostense, and J. K. Radder The Association between Abdominal Visceral Fat and Carotid Stiffness Is Mediated by Circulating Inflammatory Markers in Uncomplicated Type 2 Diabetes J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1495 - 1501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Miller, B. M. K. Biller, J. G. Lipman, G. Bradwin, N. Rifai, and A. Klibanski Truncal Adiposity, Relative Growth Hormone Deficiency, and Cardiovascular Risk J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 768 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Brotman, E. Walker, M. S. Lauer, and R. G. O'Brien In Search of Fewer Independent Risk Factors Arch Intern Med, January 24, 2005; 165(2): 138 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Roberts and R. J. Barnard Effects of exercise and diet on chronic disease J Appl Physiol, January 1, 2005; 98(1): 3 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tricon, G. C Burdge, S. Kew, T. Banerjee, J. J Russell, R. F Grimble, C. M Williams, P. C Calder, and P. Yaqoob Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1626 - 1633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. St. Jeor, L. L. Hayman, S. R. Daniels, M. W. Gillman, G. Howard, C. M. Law, C. E. Lewis, and E. Poehlman Prevention Conference VII: Obesity, a Worldwide Epidemic Related to Heart Disease and Stroke: Group II: Age-Dependent Risk Factors for Obesity and Comorbidities Circulation, November 2, 2004; 110(18): e471 - e475. [Full Text] [PDF]
|
|
|
|
|
|
S. Klein, L. E. Burke, G. A. Bray, S. Blair, D. B. Allison, X. Pi-Sunyer, Y. Hong, and R. H. Eckel Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease: A Statement for Professionals From the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation Circulation, November 2, 2004; 110(18): 2952 - 2967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Despres CRP and Risk of Coronary Heart Disease: Can Exercise Training Cool Down the Flames? Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1743 - 1745. [Full Text] [PDF]
|
|
|
|
|
|
K. Okita, H. Nishijima, T. Murakami, T. Nagai, N. Morita, K. Yonezawa, K. Iizuka, H. Kawaguchi, and A. Kitabatake Can Exercise Training With Weight Loss Lower Serum C-Reactive Protein Levels? Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1868 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lambert, E. E. Delvin, G. Paradis, J. O'Loughlin, J. A. Hanley, and E. Levy C-Reactive Protein and Features of the Metabolic Syndrome in a Population-Based Sample of Children and Adolescents Clin. Chem., October 1, 2004; 50(10): 1762 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Engstrom, B. Hedblad, L. Stavenow, S. Jonsson, P. Lind, L. Janzon, and F. Lindgarde Incidence of Obesity-Associated Cardiovascular Disease Is Related to Inflammation-Sensitive Plasma Proteins: A Population-Based Cohort Study Arterioscler Thromb Vasc Biol, August 1, 2004; 24(8): 1498 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Teragawa, Y Fukuda, K Matsuda, K Ueda, Y Higashi, T Oshima, M Yoshizumi, and K Chayama Relation between C reactive protein concentrations and coronary microvascular endothelial function Heart, July 1, 2004; 90(7): 750 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Greenfield, K. Samaras, A. B. Jenkins, P. J. Kelly, T. D. Spector, J. R. Gallimore, M. B. Pepys, and L. V. Campbell Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic Influences Circulation, June 22, 2004; 109(24): 3022 - 3028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jang, O. Y. Kim, H. J. Ryu, J. Y. Kim, S. H. Song, J. M. Ordovas, and J. H. Lee Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men J. Lipid Res., December 1, 2003; 44(12): 2356 - 2364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Morin-Papunen, K. Rautio, A. Ruokonen, P. Hedberg, M. Puukka, and J. S. Tapanainen Metformin Reduces Serum C-Reactive Protein Levels in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 4649 - 4654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chandalia, A. V. Cabo-Chan Jr, S. Devaraj, I. Jialal, S. M. Grundy, and N. Abate Elevated Plasma High-Sensitivity C-Reactive Protein Concentrations in Asian Indians Living in the United States J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3773 - 3776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.P. Kopp, C.W. Kopp, A. Festa, K. Krzyzanowska, S. Kriwanek, E. Minar, R. Roka, and G. Schernthaner Impact of Weight Loss on Inflammatory Proteins and Their Association With the Insulin Resistance Syndrome in Morbidly Obese Patients Arterioscler Thromb Vasc Biol, June 1, 2003; 23(6): 1042 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Despres, I. Lemieux, A. Pascot, N. Almeras, M. Dumont, A. Nadeau, J. Bergeron, and D. Prud'homme Gemfibrozil Reduces Plasma C-Reactive Protein Levels in Abdominally Obese Men With the Atherogenic Dyslipidemia of the Metabolic Syndrome Arterioscler Thromb Vasc Biol, April 1, 2003; 23(4): 702 - 703. [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Isasi, R. J. Deckelbaum, R. P. Tracy, T. J. Starc, L. Berglund, and S. Shea Physical Fitness and C-Reactive Protein Level in Children and Young Adults: The Columbia University BioMarkers Study Pediatrics, February 1, 2003; 111(2): 332 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Pearson, G. A. Mensah, R. W. Alexander, J. L. Anderson, R. O. Cannon III, M. Criqui, Y. Y. Fadl, S. P. Fortmann, Y. Hong, G. L. Myers, et al. Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association Circulation, January 28, 2003; 107(3): 499 - 511. [Full Text] [PDF]
|
|
|
|
|
|
R. A. Hegele, M. E. Kraw, M. R. Ban, B. A. Miskie, M. W. Huff, and H. Cao Elevated Serum C-Reactive Protein and Free Fatty Acids Among Nondiabetic Carriers of Missense Mutations in the Gene Encoding Lamin A/C (LMNA) With Partial Lipodystrophy Arterioscler Thromb Vasc Biol, January 1, 2003; 23(1): 111 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. McLaughlin, F. Abbasi, C. Lamendola, L. Liang, G. Reaven, P. Schaaf, and P. Reaven Differentiation Between Obesity and Insulin Resistance in the Association With C-Reactive Protein Circulation, December 3, 2002; 106(23): 2908 - 2912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Davi, M. T. Guagnano, G. Ciabattoni, S. Basili, A. Falco, M. Marinopiccoli, M. Nutini, S. Sensi, and C. Patrono Platelet Activation in Obese Women: Role of Inflammation and Oxidant Stress JAMA, October 23, 2002; 288(16): 2008 - 2014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Riserus, S. Basu, S. Jovinge, G. N. Fredrikson, J. Arnlov, and B. Vessby Supplementation With Conjugated Linoleic Acid Causes Isomer-Dependent Oxidative Stress and Elevated C-Reactive Protein: A Potential Link to Fatty Acid-Induced Insulin Resistance Circulation, October 8, 2002; 106(15): 1925 - 1929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Colhoun, C. Schalkwijk, M. B. Rubens, and C. D.A. Stehouwer C-Reactive Protein in Type 1 Diabetes and Its Relationship to Coronary Artery Calcification Diabetes Care, October 1, 2002; 25(10): 1813 - 1817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Tracy Is Visceral Adiposity the "Enemy Within"? Arterioscler Thromb Vasc Biol, June 1, 2001; 21(6): 881 - 883. [Full Text] [PDF]
|
|
|
|
|
|
P. Ziccardi, F. Nappo, G. Giugliano, K. Esposito, R. Marfella, M. Cioffi, F. D'Andrea, A. M. Molinari, and D. Giugliano Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year Circulation, February 19, 2002; 105(7): 804 - 809. [Abstract] [Full Text] [PDF]
|
|