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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2001;21:1090.)
© 2001 American Heart Association, Inc.

Letters to the Editor

Elevated Circulating Levels of Monocyte Chemoattractant Protein-1 in Patients With Restenosis After Coronary Angioplasty

Uichi Ikeda; Kazuyuki Shimada

Department of Cardiology, Jichi Medical School, Tochigi, Japan

To the Editor:

We read with great interest the article by Cipollone et al¹ on the expression of monocyte chemoattractant protein-1 (MCP-1) after percutaneous transluminal coronary angioplasty (PTCA). In their study, plasma MCP-1 levels were significantly increased 1 day after PTCA, and patients with restenosis showed significantly higher MCP-1 levels after PTCA than those without restenosis. Several previous studies, including our own, have revealed that PTCA induces inflammatory responses.² In addition, we reported that MCP-1 is expressed in human atherosclerotic lesions³ and that the interaction between monocytes and endothelial cells induces MCP-1 expression and enhances monocyte migration.^{4 5} Therefore, like Cipollone et al,¹ we hypothesized that MCP-1 played important roles in restenosis after intervention.

To prove our hypothesis, we examined 40 patients with angina pectoris who underwent elective PTCA for isolated stenotic lesions of the left coronary artery.⁶ A 5F Amplatz catheter was placed in the coronary sinus, and blood samples were obtained through the catheter before, immediately after, and 4 and 24 hours after angioplasty. Blood samples were also obtained from the femoral artery 24 hours after angioplasty. Plasma levels of MCP-1 and macrophage-colony stimulating factor (M-CSF) were measured by specific enzyme immunoassays. M-CSF levels in the coronary sinus blood showed a significant increase 4 and 24 hours after PTCA (from [mean±SD] 671±51 to 942±63 and to 1220±79 pg/mL, respectively). In the femoral arterial blood, a slight increase in M-CSF levels was found 24 hours after PTCA; however, the difference was not significant (from 681±135 to 865±156 pg/mL, P=0.155). . . . [Full Text of this Article]

Francesco Cipollone; Andrea Mezzetti

Department of Medicine and Aging Sciences, Policlinico SS Annunziata, University of Chieti, "G. D’annunzio," Chieti, Italy

This article has been cited by other articles:

				P. K. Shah Inflammation, Neointimal Hyperplasia, and Restenosis: As the Leukocytes Roll, the Arteries Thicken Circulation, May 6, 2003; 107(17): 2175 - 2177. [Full Text] [PDF]