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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2001;21:1823.)
© 2001 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Genome Scan for Quantitative Trait Loci Linked to High-Density Lipoprotein Cholesterol

The NHLBI Family Heart Study

James M. Peacock; Donna K. Arnett; Larry D. Atwood; Richard H. Myers; Hilary Coon; Stephen S. Rich; Michael A. Province; Gerardo Heiss; on behalf of the Investigators of the NHLBI Family Heart Study

From the Division of Epidemiology (J.M.P., D.K.A., L.D.A.), School of Public Health, University of Minnesota, Minneapolis, Minn; Section of Preventive Medicine and Epidemiology (R.H.M.), Boston University School of Medicine, Boston, Mass; Department of Psychiatry (H.C.), University of Utah, Salt Lake City, Utah; Department of Public Health Sciences (S.S.R.), Wake Forest University School of Medicine, Winston-Salem, NC; Division of Biostatistics (M.A.P.), Washington University Medical School, Saint Louis, Mo; and Department of Epidemiology (G.H.), University of North Carolina, Chapel Hill, NC.

Reprint requests to Donna K. Arnett, PhD, Division of Epidemiology, School of Public Health, University of Minnesota, 1300 S 2nd St, Suite 300, Minneapolis, MN 55454. E-mail arnett{at}epi.umn.edu

Abstract—— We conducted a genome-wide linkage scan for quantitative trait loci influencing total HDL-cholesterol (HDL-C) concentration in a sample of 1027 whites from 101 families participating in the NHLBI Family Heart Study. To maximize the relative contribution of genetic components of variance to the total variance of HDL-C, the HDL-C phenotype was adjusted for age, age², body mass index, and Family Heart Study field center, and standardized HDL-C residuals were created separately for men and women. All analyses were completed by the variance components method, as implemented in the program GENEHUNTER using 383 anonymous markers typed at the NHLBI Mammalian Genotyping Service in Marshfield, Wis. Evidence for linkage of residual HDL-C was detected near marker D5S1470 at location 39.9 cM from the p-terminal of chromosome 5 (LOD=3.64). Suggestive linkage was detected near marker D13S1493 at location 27.5 cM on chromosome 13 (LOD=2.36). We conclude that at least 1 genomic region is likely to harbor a gene that influences interindividual variation in HDL cholesterol.

Key Words: HDL cholesterol • genome scan • anonymous marker linkage • quantitative trait loci • genetic epidemiology

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