Arteriosclerosis, Thrombosis, and Vascular Biology. 2001;21:1816-1822
doi: 10.1161/hq1101.097803
doi: 10.1161/hq1101.097803
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© 2001 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Relationship of Periodontal Disease to Carotid Artery Intima-Media Wall Thickness
The Atherosclerosis Risk in Communities (ARIC) Study
From the University of North Carolina at Chapel Hill, Chapel Hill, NC.
Correspondence to James D. Beck, Co-Director, Center for Oral and Systemic Diseases and Center for Inflammatory Disorders, School of Dentistry, CB#7455, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7455. E-mail jim_beck{at}dentistry.unc.edu
Abstract—— Periodontitis has been linked to clinical cardiovascular disease but not to subclinical atherosclerosis. The purpose of this study was to determine whether periodontitis is associated with carotid artery intima-media wall thickness (IMT). Cross-sectional data on 6017 persons aged 52 to 75 years were obtained from the Atherosclerosis Risk in Communities Study 1996 to 1998 examination. The dependent variable was carotid IMT 
1 mm. Periodontitis was defined by extent of attachment loss 3 mm: none/mild (<10%), moderate (10% to <30%), or severe (30%). Covariates included age, sex, diabetes, LDL cholesterol, HDL cholesterol, triglycerides, hypertension, smoking, waist-hip ratio, education, and race/study center. Odds of IMT 1 mm were higher for severe periodontitis (OR 2.09, 95% CI 1.73 to 2.53) and moderate periodontitis (OR 1.40, CI 1.17 to 1.67) compared with no periodontitis. In a multivariable logistic regression model, severe periodontitis (OR 1.31, CI 1.03 to 1.66) was associated with IMT 1 mm, while adjusting for the other factors in the model. These results provide the first indication that periodontitis may play a role in the pathogenesis of atheroma formation, as well as in cardiovascular events.
Key Words: periodontitis • periodontal disease • mouth diseases • carotid artery diseases • atherosclerosis • ultrasonics
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