| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atherosclerosis and Lipoproteins |
From the University of North Carolina at Chapel Hill, Chapel Hill, NC.
Correspondence to James D. Beck, Co-Director, Center for Oral and Systemic Diseases and Center for Inflammatory Disorders, School of Dentistry, CB#7455, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7455. E-mail jim_beck{at}dentistry.unc.edu
Abstract Periodontitis has been linked to clinical cardiovascular disease but not to subclinical atherosclerosis. The purpose of this study was to determine whether periodontitis is associated with carotid artery intima-media wall thickness (IMT). Cross-sectional data on 6017 persons aged 52 to 75 years were obtained from the Atherosclerosis Risk in Communities Study 1996 to 1998 examination. The dependent variable was carotid IMT
1 mm. Periodontitis was defined by extent of attachment loss
3 mm: none/mild (<10%), moderate (10% to <30%), or severe (
30%). Covariates included age, sex, diabetes, LDL cholesterol, HDL cholesterol, triglycerides, hypertension, smoking, waist-hip ratio, education, and race/study center. Odds of IMT
1 mm were higher for severe periodontitis (OR 2.09, 95% CI 1.73 to 2.53) and moderate periodontitis (OR 1.40, CI 1.17 to 1.67) compared with no periodontitis. In a multivariable logistic regression model, severe periodontitis (OR 1.31, CI 1.03 to 1.66) was associated with IMT
1 mm, while adjusting for the other factors in the model. These results provide the first indication that periodontitis may play a role in the pathogenesis of atheroma formation, as well as in cardiovascular events.
Key Words: periodontitis periodontal disease mouth diseases carotid artery diseases atherosclerosis ultrasonics
This article has been cited by other articles:
![]() |
D. J. Caplan, J. S. Pankow, J. Cai, S. Offenbacher, and J. D. Beck The Relationship Between Self-Reported History of Endodontic Therapy and Coronary Heart Disease in the Atherosclerosis Risk in Communities Study J Am Dent Assoc, August 1, 2009; 140(8): 1004 - 1012. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. M. Treadwell and A. J. Formicola Improving the Oral Health of Prisoners to Improve Overall Health and Well-Being Am J Public Health, September 1, 2008; 98(Supplement_1): S171 - S172. [Full Text] [PDF] |
||||
![]() |
Y. Koizumi, T. Kurita-Ochiai, S. Oguchi, and M. Yamamoto Nasal Immunization with Porphyromonas gingivalis Outer Membrane Protein Decreases P. gingivalis-Induced Atherosclerosis and Inflammation in Spontaneously Hyperlipidemic Mice Infect. Immun., July 1, 2008; 76(7): 2958 - 2965. [Abstract] [Full Text] [PDF] |
||||
![]() |
R A Pollitt, J S Kaufman, K M Rose, A V Diez-Roux, D Zeng, and G Heiss Cumulative life course and adult socioeconomic status and markers of inflammation in adulthood J Epidemiol Community Health, June 1, 2008; 62(6): 484 - 491. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Orozco, E. Gemmell, M. Bickel, and G.J. Seymour Interleukin 18 and Periodontal Disease Journal of Dental Research, July 1, 2007; 86(7): 586 - 593. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. S. Tonetti, F. D'Aiuto, L. Nibali, A. Donald, C. Storry, M. Parkar, J. Suvan, A. D. Hingorani, P. Vallance, and J. Deanfield Treatment of Periodontitis and Endothelial Function N. Engl. J. Med., March 1, 2007; 356(9): 911 - 920. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. A. Shultis, E. J. Weil, H. C. Looker, J. M. Curtis, M. Shlossman, R. J. Genco, W. C. Knowler, and R. G. Nelson Effect of Periodontitis on Overt Nephropathy and End-Stage Renal Disease in Type 2 Diabetes Diabetes Care, February 1, 2007; 30(2): 306 - 311. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. S. Pankow, D. K. Kwan, B. B. Duncan, M. I. Schmidt, D. J. Couper, S. Golden, and C. M. Ballantyne Cardiometabolic Risk in Impaired Fasting Glucose and Impaired Glucose Tolerance: The Atherosclerosis Risk in Communities Study Diabetes Care, February 1, 2007; 30(2): 325 - 331. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Suzuki, E. Bayna, H. L. Li, E. D. Molle, and W. Y.W. Lew Lipopolysaccharide Activates Calcineurin in Ventricular Myocytes J. Am. Coll. Cardiol., January 30, 2007; 49(4): 491 - 499. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. T. Demmer and M. Desvarieux Periodontal infections and cardiovascular disease: The heart of the matter J Am Dent Assoc, October 1, 2006; 137(suppl_2): 14S - 20S. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Harokopakis, M. H. Albzreh, M. H. Martin, and G. Hajishengallis TLR2 Transmodulates Monocyte Adhesion and Transmigration via Rac1- and PI3K-Mediated Inside-Out Signaling in Response to Porphyromonas gingivalis Fimbriae. J. Immunol., June 15, 2006; 176(12): 7645 - 7656. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. N. Borrell, J. D. Beck, and G. Heiss Socioeconomic Disadvantage and Periodontal Disease: The Dental Atherosclerosis Risk in Communities Study Am J Public Health, February 1, 2006; 96(2): 332 - 339. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. L. Rufail, H. A. Schenkein, S. E. Barbour, J. G. Tew, and R. van Antwerpen Altered lipoprotein subclass distribution and PAF-AH activity in subjects with generalized aggressive periodontitis J. Lipid Res., December 1, 2005; 46(12): 2752 - 2760. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Song, M. Belanger, J. Whitlock, E. Kozarov, and A. Progulske-Fox Hemagglutinin B Is Involved in the Adherence of Porphyromonas gingivalis to Human Coronary Artery Endothelial Cells Infect. Immun., November 1, 2005; 73(11): 7267 - 7273. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. M. Treadwell and A. J. Formicola Improving the Oral Health of Prisoners to Improve Overall Health and Well-Being Am J Public Health, October 1, 2005; 95(10): 1677 - 1678. [Full Text] [PDF] |
||||
![]() |
J. H. Southerland, G. W. Taylor, and S. Offenbacher Diabetes and Periodontal Infection: Making the Connection Clin. Diabetes, October 1, 2005; 23(4): 171 - 178. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Kivimaki, D. A. Lawlor, M. Juonala, G. Davey Smith, M. Elovainio, L. Keltikangas-Jarvinen, J. Vahtera, J. S.A. Viikari, and O. T. Raitakari Lifecourse Socioeconomic Position, C-Reactive Protein, and Carotid Intima-Media Thickness in Young Adults: The Cardiovascular Risk in Young Finns Study Arterioscler Thromb Vasc Biol, October 1, 2005; 25(10): 2197 - 2202. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D. Beck, P. Eke, G. Heiss, P. Madianos, D. Couper, D. Lin, K. Moss, J. Elter, and S. Offenbacher Periodontal Disease and Coronary Heart Disease: A Reappraisal of the Exposure Circulation, July 5, 2005; 112(1): 19 - 24. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Brodala, E. P. Merricks, D. A. Bellinger, D. Damrongsri, S. Offenbacher, J. Beck, P. Madianos, D. Sotres, Y.-L. Chang, G. Koch, et al. Porphyromonas gingivalis Bacteremia Induces Coronary and Aortic Atherosclerosis in Normocholesterolemic and Hypercholesterolemic Pigs Arterioscler Thromb Vasc Biol, July 1, 2005; 25(7): 1446 - 1451. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. J. Pussinen, K. Nyyssonen, G. Alfthan, R. Salonen, J. A. Laukkanen, and J. T. Salonen Serum Antibody Levels to Actinobacillus actinomycetemcomitans Predict the Risk for Coronary Heart Disease Arterioscler Thromb Vasc Biol, April 1, 2005; 25(4): 833 - 838. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. P. Engebretson, I. B. Lamster, M. S.V. Elkind, T. Rundek, N. J. Serman, R. T. Demmer, R. L. Sacco, P. N. Papapanou, and M. Desvarieux Radiographic Measures of Chronic Periodontitis and Carotid Artery Plaque Stroke, March 1, 2005; 36(3): 561 - 566. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Desvarieux, R. T. Demmer, T. Rundek, B. Boden-Albala, D. R. Jacobs Jr, R. L. Sacco, and P. N. Papapanou Periodontal Microbiota and Carotid Intima-Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study (INVEST) Circulation, February 8, 2005; 111(5): 576 - 582. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. H. Meurman, M. Sanz, and S.-J. Janket ORAL HEALTH, ATHEROSCLEROSIS, AND CARDIOVASCULAR DISEASE Critical Reviews in Oral Biology & Medicine, November 1, 2004; 15(6): 403 - 413. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. C. Gibson III, C. Hong, H.-H. Chou, H. Yumoto, J. Chen, E. Lien, J. Wong, and C. Attardo Genco Innate Immune Recognition of Invasive Bacteria Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice Circulation, June 8, 2004; 109(22): 2801 - 2806. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Taguchi, M. Sanada, Y. Suei, M. Ohtsuka, K. Lee, K. Tanimoto, M. Tsuda, K. Ohama, M. Yoshizumi, and Y. Higashi Tooth Loss Is Associated With an Increased Risk of Hypertension in Postmenopausal Women Hypertension, June 1, 2004; 43(6): 1297 - 1300. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. D'Aiuto, M. Parkar, G. Andreou, J. Suvan, P.M. Brett, D. Ready, and M.S. Tonetti Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers Journal of Dental Research, February 1, 2004; 83(2): 156 - 160. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. J. Pussinen, M. Jauhiainen, T. Vilkuna-Rautiainen, J. Sundvall, M. Vesanen, K. Mattila, T. Palosuo, G. Alfthan, and S. Asikainen Periodontitis decreases the antiatherogenic potency of high density lipoprotein J. Lipid Res., January 1, 2004; 45(1): 139 - 147. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.R. Elter, S. Offenbacher, J.F. Toole, and J.D. Beck Relationship of Periodontal Disease and Edentulism to Stroke/TIA Journal of Dental Research, December 1, 2003; 82(12): 998 - 1001. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.A. Schenkein, C.R. Berry, J.A. Burmeister, C.N. Brooks, S.E. Barbour, A.M. Best, and J.G. Tew Anti-cardiolipin Antibodies in Sera from Patients with Periodontitis Journal of Dental Research, November 1, 2003; 82(11): 919 - 922. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Desvarieux, R. T. Demmer, T. Rundek, B. Boden-Albala, D. R. Jacobs Jr, P. N. Papapanou, and R. L. Sacco Relationship Between Periodontal Disease, Tooth Loss, and Carotid Artery Plaque: The Oral Infections and Vascular Disease Epidemiology Study (INVEST) Stroke, September 1, 2003; 34(9): 2120 - 2125. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. J. Pussinen, P. Jousilahti, G. Alfthan, T. Palosuo, S. Asikainen, and V. Salomaa Antibodies to Periodontal Pathogens Are Associated With Coronary Heart Disease Arterioscler Thromb Vasc Biol, July 1, 2003; 23(7): 1250 - 1254. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Amar, N. Gokce, S. Morgan, M. Loukideli, T. E. Van Dyke, and J. A. Vita Periodontal Disease Is Associated With Brachial Artery Endothelial Dysfunction and Systemic Inflammation Arterioscler Thromb Vasc Biol, July 1, 2003; 23(7): 1245 - 1249. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. W. FONG Infections and their role in atherosclerotic vascular disease J Am Dent Assoc, June 1, 2002; 133(suppl_1): 7S - 13S. [Abstract] [Full Text] [PDF] |
||||
|
ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search Copyright © 2001 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. |