Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:1595-1599
© 2000 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
From the Department of Internal Medicine and Molecular Science (K. Hotta, T.F., Y.A., M.T., M. Matsuda, Y. Okamoto, H.I., H.K., N.O., K.M., M.N., S.K., N.S., T. Nakamura, S.Y., T.H., Y.M.), Graduate School of Medicine, Osaka University, Osaka, Japan; the Toyonaka City Hospital (T. Nakajima), Osaka, Japan; the Health Administration Department (K. Hasegawa), ITOCHU Corporation, Osaka, Japan; and the Cellular Technology Institute (M. Muraguchi, Y. Ohmoto), Otsuka Pharmaceutical Co, Ltd., Tokushima, Japan.
Correspondence to Kikuko Hotta, MD, PhD, Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail khotta{at}imed2.med.osaka-u.ac.jp
Abstract—Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed the plasma adiponectin concentrations in age- and body mass index (BMI)–matched nondiabetic and type 2 diabetic subjects with and without coronary artery disease (CAD). Plasma levels of adiponectin in the diabetic subjects without CAD were lower than those in nondiabetic subjects (6.6±0.4 versus 7.9±0.5 µg/mL in men, 7.6±0.7 versus 11.7±1.0 µg/mL in women; P<0.001). The plasma adiponectin concentrations of diabetic patients with CAD were lower than those of diabetic patients without CAD (4.0±0.4 versus 6.6±0.4 µg/mL, P<0.001 in men; 6.3±0.8 versus 7.6±0.7 µg/mL in women). In contrast, plasma levels of leptin did not differ between diabetic patients with and without CAD. The presence of microangiopathy did not affect the plasma adiponectin levels in diabetic patients. Significant, univariate, inverse correlations were observed between adiponectin levels and fasting plasma insulin (r=-0.18, P<0.01) and glucose (r=-0.26, P<0.001) levels. In multivariate analysis, plasma insulin did not independently affect the plasma adiponectin levels. BMI, serum triglyceride concentration, and the presence of diabetes or CAD remained significantly related to plasma adiponectin concentrations. Weight reduction significantly elevated plasma adiponectin levels in the diabetic subjects as well as the nondiabetic subjects. These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy.
Key Words: adiponectin • diabetes mellitus • coronary artery disease • adipose tissue
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D. Barb, C. J Williams, A. K Neuwirth, and C. S Mantzoros Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence Am. J. Clinical Nutrition, September 1, 2007; 86(3): 858S - 866S. [Abstract] [Full Text] [PDF]
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W.-S. Yang, Y.-C. Yang, C.-L. Chen, I-L. Wu, J.-Y. Lu, F.-H. Lu, T.-Y. Tai, and C.-J. Chang Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly Am. J. Clinical Nutrition, August 1, 2007; 86(2): 509 - 513. [Abstract] [Full Text] [PDF]
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S.-K. Kim, K.-Y. Hur, H.-J. Kim, W.-S. Shim, C.-W. Ahn, S.-W. Park, Y.-W. Cho, S.-K. Lim, H.-C. Lee, and B.-S. Cha The increase in abdominal subcutaneous fat depot is an independent factor to determine the glycemic control after rosiglitazone treatment Eur. J. Endocrinol., August 1, 2007; 157(2): 167 - 174. [Abstract] [Full Text] [PDF]
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A. E Schutte, H. W Huisman, R. Schutte, L. Malan, J. M van Rooyen, N. T Malan, and P. E H Schwarz Differences and similarities regarding adiponectin investigated in African and Caucasian women Eur. J. Endocrinol., August 1, 2007; 157(2): 181 - 188. [Abstract] [Full Text] [PDF]
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G. Yuan, X. Chen, Q. Ma, J. Qiao, R. Li, X. Li, S. Li, J. Tang, L. Zhou, H. Song, et al. C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes J. Endocrinol., August 1, 2007; 194(2): 275 - 281. [Abstract] [Full Text] [PDF]
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R. Muniyappa, M. Montagnani, K. K. Koh, and M. J. Quon Cardiovascular Actions of Insulin Endocr. Rev., August 1, 2007; 28(5): 463 - 491. [Abstract] [Full Text] [PDF]
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M. Cesari, K. Narkiewicz, R. De Toni, E. Aldighieri, C. J. Williams, and G. P. Rossi Heritability of Plasma Adiponectin Levels and Body Mass Index in Twins J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3082 - 3088. [Abstract] [Full Text] [PDF]
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A. J. G. Hanley, D. Bowden, L. E. Wagenknecht, A. Balasubramanyam, C. Langfeld, M. F. Saad, J. I. Rotter, X. Guo, Y.-D. I. Chen, M. Bryer-Ash, et al. Associations of Adiponectin with Body Fat Distribution and Insulin Sensitivity in Nondiabetic Hispanics and African-Americans J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2665 - 2671. [Abstract] [Full Text] [PDF]
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J. Jurimae and T. Jurimae Plasma adiponectin concentration in healthy pre- and postmenopausal women: relationship with body composition, bone mineral, and metabolic variables Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E42 - E47. [Abstract] [Full Text] [PDF]
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S. Otabe, X. Yuan, T. Fukutani, N. Wada, T. Hashinaga, H. Nakayama, N. Hirota, M. Kojima, and K. Yamada Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E210 - E218. [Abstract] [Full Text] [PDF]
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V. B. O'Leary, A. E. Jorett, C. M. Marchetti, F. Gonzalez, S. A. Phillips, T. P. Ciaraldi, and J. P. Kirwan Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E421 - E427. [Abstract] [Full Text] [PDF]
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C. Menzaghi, V. Trischitta, and A. Doria Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease Diabetes, May 1, 2007; 56(5): 1198 - 1209. [Abstract] [Full Text] [PDF]
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R. Jaumdally, C. Varma, R. J. Macfadyen, and G. Y.H. Lip Coronary sinus blood sampling: an insight into local cardiac pathophysiology and treatment? Eur. Heart J., April 2, 2007; 28(8): 929 - 940. [Abstract] [Full Text] [PDF]
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N. Hosogai, A. Fukuhara, K. Oshima, Y. Miyata, S. Tanaka, K. Segawa, S. Furukawa, Y. Tochino, R. Komuro, M. Matsuda, et al. Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation Diabetes, April 1, 2007; 56(4): 901 - 911. [Abstract] [Full Text] [PDF]
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C.-C. Juan, T.-Y. Chuang, C.-L. Chang, S.-W. Huang, and L.-T. Ho Endothelin-1 Regulates Adiponectin Gene Expression and Secretion in 3T3-L1 Adipocytes via Distinct Signaling Pathways Endocrinology, April 1, 2007; 148(4): 1835 - 1842. [Abstract] [Full Text] [PDF]
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I. B. Bauche, S. A. El Mkadem, A.-M. Pottier, M. Senou, M.-C. Many, R. Rezsohazy, L. Penicaud, N. Maeda, T. Funahashi, and S. M. Brichard Overexpression of Adiponectin Targeted to Adipose Tissue in Transgenic Mice: Impaired Adipocyte Differentiation Endocrinology, April 1, 2007; 148(4): 1539 - 1549. [Abstract] [Full Text] [PDF]
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T. A. Hopkins, N. Ouchi, R. Shibata, and K. Walsh Adiponectin actions in the cardiovascular system Cardiovasc Res, April 1, 2007; 74(1): 11 - 18. [Abstract] [Full Text] [PDF]
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R. P F Dullaart, R. de Vries, A. van Tol, and W. J Sluiter Lower plasma adiponectin is a marker of increased intima-media thickness associated with type 2 diabetes mellitus and with male gender Eur. J. Endocrinol., March 1, 2007; 156(3): 387 - 394. [Abstract] [Full Text] [PDF]
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K. G. Tolman, V. Fonseca, A. Dalpiaz, and M. H. Tan Spectrum of Liver Disease in Type 2 Diabetes and Management of Patients With Diabetes and Liver Disease Diabetes Care, March 1, 2007; 30(3): 734 - 743. [Full Text] [PDF]
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M. Bjursell, A. Ahnmark, M. Bohlooly-Y, L. William-Olsson, M. Rhedin, X.-R. Peng, K. Ploj, A.-K. Gerdin, G. Arnerup, A. Elmgren, et al. Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism Diabetes, March 1, 2007; 56(3): 583 - 593. [Abstract] [Full Text] [PDF]
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S. H. Han, M. J. Quon, J.-a Kim, and K. K. Koh Adiponectin and Cardiovascular Disease: Response to Therapeutic Interventions J. Am. Coll. Cardiol., February 6, 2007; 49(5): 531 - 538. [Abstract] [Full Text] [PDF]
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