This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schuler-Lüttmann, S. Articles by von Eckardstein, A. Search for Related Content PubMed PubMed Citation Articles by Schuler-Lüttmann, S. Articles by von Eckardstein, A. Related Collections Risk Factors Other arteriosclerosis Growth factors/cytokines Coronary imaging: angiography/ultrasound/Doppler/CC Lipid and lipoprotein metabolism

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:e10.)
© 2000 American Heart Association, Inc.

ATVB Electronic Pages

Insulin-Like Growth Factor–Binding Protein-3 Is Associated With the Presence and Extent of Coronary Arteriosclerosis

Susanne Schuler-Lüttmann; Gerold Mönnig; Annette Enbergs; Helmut Schulte; Günter Breithardt; Gerd Assmann; Sebastian Kerber; Arnold von Eckardstein

From the Institut für Arterioskleroseforschung an der Universität Münster (S.S.-L., H.S., G.B., G.A., A.v.E.), the Medizinische Klinik und Poliklinik C (Kardiologie, Angiologie) (G.M., A.E., G.B., S.K.), the Institut für Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, and the Interdisziplinäres Zentrum für Klinische Forschung (IZKF), Medizinische Fakultät (A.v.E.), Westfälische Wilhelms-Universität Münster, Münster, Germany.

Correspondence to Dr Arnold von Eckardstein, Institut für Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfälische Wilhelms-Universität Münster, Albert-Schweitzer-Strasse 33, D-48149 Münster, Germany. E-mail vonecka{at}uni-muenster.de

Abstract

Abstract—Aging is associated with the progression of arteriosclerosis and the decline of several endocrine functions. We therefore investigated the association of coronary arteriosclerosis with hormones, the serum concentrations of which change during aging. Coronary angiograms of 189 men <70 years old were evaluated by 3 semiquantitative score systems to estimate the extent of focal and diffuse vessel wall alterations. Fasting sera were analyzed for levels of glucose, lipids, thyroid-stimulating hormone, insulin, insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), dehydroepiandrosterone sulfate (DHEAS), testosterone, and sex hormone–binding globulin (SHBG). After adjustment for age, body mass index, and waist-to-hip ratio, 92 patients with 1 stenoses >70% differed from 97 patients without such focal lesions by higher serum levels of glucose, total and LDL cholesterol, and apolipoprotein (apo) B, as well as by lower serum levels of IGFBP-3. Multivariate analyses revealed significant and independent correlations of all 3 coronary scores with LDL cholesterol (or apoB) and IGFBP-3; of 2 coronary scores with age, glucose, and insulin; and of 1 score with IGF-I. No significant correlations existed for waist-to-hip ratio (or body mass index) and DHEAS (or testosterone or SHBG). IGFBP-3 explained 9% to 14% and 3.5% to 10% of the variances of focal and diffuse lesions, respectively. In conclusion, IGFBP-3 and, with much less strength and consistency, insulin and IGF-I, but not markers of hypothyroidism, adrenopause, and andropause, have statistically significant and independent associations with coronary arteriosclerosis in men.

Key Words: aging • androgens • growth hormone • insulin resistance • quantitative coronary angiography

This article has been cited by other articles:

				S.-i. Kawachi, N. Takeda, A. Sasaki, Y. Kokubo, K. Takami, H. Sarui, M. Hayashi, N. Yamakita, and K. Yasuda Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Are Associated With Early Carotid Atherosclerosis Arterioscler Thromb Vasc Biol, March 1, 2005; 25(3): 617 - 621. [Abstract] [Full Text] [PDF]

				P. Delafontaine, Y.-H. Song, and Y. Li Expression, Regulation, and Function of IGF-1, IGF-1R, and IGF-1 Binding Proteins in Blood Vessels Arterioscler Thromb Vasc Biol, March 1, 2004; 24(3): 435 - 444. [Abstract] [Full Text]

				F. C. W. Wu and A. von Eckardstein Androgens and Coronary Artery Disease Endocr. Rev., April 1, 2003; 24(2): 183 - 217. [Abstract] [Full Text] [PDF]