© 2000 American Heart Association, Inc.
Vascular Biology |
The Transcription Factor NF-
B and the Regulation of Vascular Cell Function
From the Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna International Research Cooperation Center, Vienna, Austria.
Correspondence to Dr Rainer de Martin, Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna International Research Cooperation Center (VIRCC), Brunnerstrasse 59, A-1235 Vienna, Austria. E-mail rainer.de.martin{at}univie.ac.at
Abstract—A variety of
pathophysiological situations that affect cells of
the vasculature, including endothelial and smooth
muscle cells, leads to the expression of genes such as adhesion
molecules and chemokines that are dependent on members of the nuclear
factor (NF)-
B family of transcription factors. The corresponding
gene products mediate important biological functions such as immune
and inflammatory reactions, smooth muscle cell proliferation, and
angiogenesis. The beneficial and usually transient NF-B–dependent
gene expression may be exaggerated in pathological situations and
results in damage to the vessel wall and impaired vascular cell
function. In this review, we will capitalize on the favorable and
adverse roles of NF-B in the context of vascular disease, eg,
chronic and localized inflammation,
arteriosclerosis, and neoangiogenesis.
Key Words: endothelial cells • smooth muscle cells • inflammation • arteriosclerosis • angiogenesis
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