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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:2329.)
© 2000 American Heart Association, Inc.

Letters to the Editor

Resistant Hypertriglyceridemia in a Patient With High Plasma Levels of Apolipoprotein CII

Paolo Fornengo; Alberto Bruno; Roberto Gambino; Maurizio Cassader; Gianfranco Pagano

Department of Internal Medicine, University of Turin, Turin, Italy

To the Editor:

Human apolipoprotein CII (apo CII) consists of 79 amino acid residues and is required as a cofactor in the hydrolysis of triacylglycerides of chylomicrons and VLDL by lipoprotein lipase.^{1 2} Familial apo CII deficiency is an autosomal recessive genetic disorder characterized by fasting hypertriglyceridemia and an accumulation of chylomicrons in the plasma.³ Shachter et al⁴ generated transgenic mice overexpressing human apo CII, and these authors reported the unexpected observation of marked hypertriglyceridemia with an accumulation of triglyceride-enriched VLDL in the plasma. We are the first to report a case of resistant hypertriglyceridemia in a young man with high plasma levels of apo CII (turbidimetric method by Alpha-Biotech, Milan, Italy).

A 42-year-old white man was referred to our lipid clinic for diet- and drug-resistant hypertriglyceridemia. His familial history was positive for cardiovascular diseases (father with hypercholesterolemia and myocardial infarction). He had stopped smoking 9 years ago. He presented a history of chest pain, but the baseline ECG and a strength test were normal. He also underwent an ultrasound scan of the abdomen, which showed normal morphology of the liver and gallbladder. His blood pressure was normal (120/80 mm Hg), and he usually performed adequate physical activity. The Table shows the lipid profile of the patient at the first visit, after 1 month of diet therapy (1800 kcal/d and total abstention from alcohol consumption), and after 1 month of diet plus 400 mg of fenofibrate. We also treated the patient with 1200 mgx3/d of gemfibrozil without changes in . . . [Full Text of this Article]

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