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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1999;19:1975-1978.)
© 1999 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Hepatic Lipase (LIPC) Promoter Polymorphism in Men With Coronary Artery Disease

Allele Frequency and Effects on Hepatic Lipase Activity and Plasma HDL-C Concentrations

Ralph V. Shohet; Gloria L. Vega; Azam Anwar; Joaquin E. Cigarroa; Scott M. Grundy; Jonathan C. Cohen

From The Center for Human Nutrition (G.L.V., S.M.G., J.C.C.), Departments of Clinical Nutrition (G.L.V., S.M.G., J.C.C.) and Internal Medicine (R.V.S., J.E.C., S.M.G., J.C.C.), University of Texas Southwestern Medical Center; and Heartplace (A.A.), Baylor University Medical Center, Dallas, Tex.

Correspondence to Jonathan C Cohen, PhD, Center for Human Nutrition, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75235-9052. E-mail cohen{at}crcdec.swmed.edu

Abstract—Hepatic lipase is an important determinant of plasma HDL concentration and LDL subclass distribution and may therefore influence susceptibility to coronary artery disease (CAD). To assess the effect of genetic variation in hepatic lipase activity on CAD susceptibility, we determined the frequency of the -514T allele of hepatic lipase in white men with CAD and in controls who did not have CAD. In men with CAD, postheparin plasma hepatic lipase activity was 15% to 20% lower in heterozygotes and 30% lower in homozygotes for the -514T allele. Allele frequencies were similar in cases and controls, however, and were consistent with Hardy-Weinberg expectation in both groups. This finding was confirmed in a second group comprising cases with premature symptomatic CAD and controls who were free of disease. These data indicate that a primary decrease in hepatic lipase activity of as much as 30% does not influence susceptibility to CAD in white men.

Key Words: hepatic lipase • risk factor • HDL • atherosclerosis • polymorphism

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