This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wang, J.-S. Articles by Cheng, L.-J. Search for Related Content PubMed PubMed Citation Articles by Wang, J.-S. Articles by Cheng, L.-J. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL CLONIDINE Medline Plus Health Information Exercise for Children Exercise and Physical Fitness Related Collections Exercise testing Autonomic, reflex, and neurohumoral control of circulation Platelets

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1999;19:1559-1565.)
© 1999 American Heart Association, Inc.

Thrombosis

Effect of Strenuous, Acute Exercise on ₂-Adrenergic Agonist–Potentiated Platelet Activation

Jong-Shyan Wang; Lee-Ju Cheng

From the Department of Physical Therapy, Chang Gung University (J.-S.W.), and the Department of Medical Technology, Foo Yin Institute of Technology (L.-J.C.), Taiwan, ROC.

Correspondence to Assistant Professor Jong-Shyan Wang, Department of Physical Therapy, Chang Gung University, 259 Wen-Hwa 1 Rd, Kwei-Shan, Tao-Tuan, Taiwan 333, ROC. E-mail s5492{at}mail.cgu.edu.tw

Abstract—Vigorous exercise transiently increases the risk of primary cardiac arrest. Strenuous, acute exercise can also increase the release of plasma epinephrine. Previous investigations have indicated that epinephrine can potentiate platelet activation by activating platelet ₂-adrenoceptors. This study investigated how strenuous, acute exercise affects ₂-adrenergic agonist–potentiated platelet activation by closely examining 15 sedentary men who exercised strenuously on a bicycle ergometer. Before and immediately after exercise, platelet adhesiveness on fibrinogen-coated surfaces, [Ca²⁺]_i in platelets, the number and affinity of ₂-adrenergic sites on the platelet surface, and plasma catecholamine levels were determined. The results of this study can be summarized as follows: (1) The affinity of ₂-adrenergic receptors on platelets decreases while the maximal binding number significantly increases after strenuous exercise, thereby correlating with the rise in plasma catecholamine levels. (2) Basal, clonidine-treated, ADP-treated, and clonidine plus ADP–treated adhesiveness and [Ca²⁺]_i in platelets increased after strenuous exercise. (3) Strenuous exercise is associated with higher percentages of ADP- and clonidine plus ADP–enhanced platelet adhesiveness and [Ca²⁺]_i than at rest. (4) The synergistic effects of clonidine on ADP-enhanced platelet adhesiveness and [Ca²⁺]_i after strenuous exercise are much greater than those at rest. Therefore, we conclude that strenuous, acute exercise enhances platelet activation, possibly by altering the performance of platelet ₂-adrenergic receptors, facilitating the ability of ADP-activated fibrinogen receptors, and enhancing fibrinogen binding to platelet fibrinogen receptors.

Key Words: exercise • platelets • adhesiveness • [Ca²⁺]_i • catecholamines

This article has been cited by other articles:

				J. Rivera, M. L. Lozano, L. Navarro-Nunez, and V. Vicente Platelet receptors and signaling in the dynamics of thrombus formation Haematologica, May 1, 2009; 94(5): 700 - 711. [Abstract] [Full Text] [PDF]

				J.-S. Wang, C.-Y. Chang, S.-E. Chow, Y.-W. Chen, and C.-M. Yang Exercise modulates platelet-nasopharyngeal carcinoma cell aggregation and subsequent tissue factor and matrix metalloproteinase activities J Appl Physiol, September 1, 2007; 103(3): 763 - 770. [Abstract] [Full Text] [PDF]

				J.-S. Wang, H.-Y. Lin, M.-L. Cheng, and M.-K. Wong Chronic intermittent hypoxia modulates eosinophil- and neutrophil-platelet aggregation and inflammatory cytokine secretion caused by strenuous exercise in men J Appl Physiol, July 1, 2007; 103(1): 305 - 314. [Abstract] [Full Text] [PDF]

				G. G. Yegutkin, S. S. Samburski, S. P. Mortensen, S. Jalkanen, and J. Gonzalez-Alonso Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humans J. Physiol., March 1, 2007; 579(2): 553 - 564. [Abstract] [Full Text] [PDF]

				J.-S. Wang, T. Lee, and S.-E. Chow Role of exercise intensities in oxidized low-density lipoprotein-mediated redox status of monocyte in men J Appl Physiol, September 1, 2006; 101(3): 740 - 744. [Abstract] [Full Text] [PDF]

				M. Pozgajova, U. J. H. Sachs, L. Hein, and B. Nieswandt Reduced thrombus stability in mice lacking the {alpha}2A-adrenergic receptor Blood, July 15, 2006; 108(2): 510 - 514. [Abstract] [Full Text] [PDF]

				A. Coppola, L. Coppola, L. dalla Mora, F. M. Limongelli, A. Grassia, L. Mastrolorenzo, G. Gombos, and G. Lucivero Vigorous exercise acutely changes platelet and B-lymphocyte CD39 expression J Appl Physiol, April 1, 2005; 98(4): 1414 - 1419. [Abstract] [Full Text] [PDF]

				J.-S. Wang, Y.-S. Li, J.-C. Chen, and Y.-W. Chen Effects of Exercise Training and Deconditioning on Platelet Aggregation Induced by Alternating Shear Stress in Men Arterioscler Thromb Vasc Biol, February 1, 2005; 25(2): 454 - 460. [Abstract] [Full Text] [PDF]

				N. A. Horn, D. M. Anastase, K. E. Hecker, J. H. Baumert, T. Robitzsch, and R. Rossaint Epinephrine Enhances Platelet-Neutrophil Adhesion in Whole Blood In Vitro Anesth. Analg., February 1, 2005; 100(2): 520 - 526. [Abstract] [Full Text] [PDF]

				Y. Cadroy, F. Pillard, K. S. Sakariassen, C. Thalamas, B. Boneu, and D. Riviere Strenuous but not moderate exercise increases the thrombotic tendency in healthy sedentary male volunteers J Appl Physiol, September 1, 2002; 93(3): 829 - 833. [Abstract] [Full Text] [PDF]