© 1999 American Heart Association, Inc.
Original Contributions |
Increased Plasma 7ß-Hydroxycholesterol Concentrations in a Population With a High Risk for Cardiovascular Disease
From the Department of Physiology and Biochemistry (A.K., Z.K.), Faculty of Medicine, Vilnius, Lithuania; the Department of Health and Environment (M.K.), Faculty of Health Sciences, and the Department of Medicine and Care and Clinical Research Center (B.Z., A.G.O.), Faculty of Health Sciences, Linköping; the Department of Geriatrics (B.V.), Uppsala University, Uppsala; and the Department of Medical Laboratory Sciences and Technology (U.D.), Division of Clinical Chemistry, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden.
Correspondence to Bo Ziedén, Clinical Research Center and Department of Medicine and Care, Faculty of Health Sciences, S-581 85 Linköping, Sweden. E-mail Bo.Zieden{at}kfc.liu.se
Abstract—The mortality in
coronary heart disease among 50- to 54-year-old men is 4 times
higher in Lithuania than in Sweden. It was recently suggested that
traditional risk factors could not explain this mortality difference.
LDL of Lithuanian men showed, however, a lower resistance to oxidation
than that of Swedish men. In addition, the plasma concentration of
-tocopherol, lycopene, and ß-carotene were lower in
Lithuanian men. In the present investigation, we determined plasma
oxysterols in men from Lithuania and Sweden and found that the plasma
concentration of 7ß-hydroxycholesterol was higher in
Lithuanian men, 12±5 versus 9±8 (SD) ng/mL (P=0.0011).
This oxysterol is a cholesterol autoxidation product
and there is no indication that it should have an enzymatic origin.
Mean LDL oxidation lag time was shorter in Lithuanian men (75±14
versus 90±13 minutes, P<0.0001) and the concentration
of LDL linoleic acid was lower (249±56 versus 292±54 µg/mg of LDL
protein, P<0.0001). Lipid corrected
-tocopherol was 0.07±0.02 mg/mL in Vilnius men and
0.12±0.04 mg/mL (P<0.0001) in Linköping men.
There was a negative correlation between the concentration of
7ß-hydroxycholesterol and lag time
(R=-0.31, P=0.0023). It is
suggested that the higher 7ß-hydroxycholesterol
concentration in Lithuanian men is an indication of an increased in
vivo lipid peroxidation.
Key Words: oxysterols • LDL oxidation • vitamins • fatty acids • cross-sectional study
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