This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wysokinski, W. E. Articles by Owen, W. G. Search for Related Content PubMed PubMed Citation Articles by Wysokinski, W. E. Articles by Owen, W. G. Related Collections Animal models of human disease Risk Factors Platelets

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1999;19:883-886.)
© 1999 American Heart Association, Inc.

Original Contributions

Individual Propensity for Arterial Thrombosis

Waldemar E. Wysokinski; Robert D. McBane, II; Whyte G. Owen

From the Section of Hematology Research (W.E.W., R.D.M., W.G.O.), the Division of Cardiovascular Medicine (R.D.M.), and the Department of Biochemistry and Molecular Biology (W.G.O.), Mayo Clinic and Foundation for Education and Research, Rochester, Minn. W.E.W. is currently at the Clinic and Department of Angiology, Medical School of Wroclaw, Wroclaw, Poland.

Correspondence to Whyte G. Owen, Mayo Clinic and Foundation, 200 SW First St, Rochester, MN 55905. E-mail wgo{at}mayo.edu

Abstract—Arterial thrombophilia independent of vascular pathology has not been previously defined either experimentally or epidemiologically. To address the existence of an individual propensity to arterial thrombosis, we exploited a previously developed procedure entailing traumatic (crush) injury of paired porcine carotid arteries for generating platelet-rich thrombi. Porcine carotid arteries were injured bilaterally by serial hemostat crushes. Thrombus generation was monitored by local accumulation of autologous ¹¹¹In-labeled platelets and Doppler blood flow. Within this cohort of animals of similar age and size, the lowest to the highest responders in thrombus mass spanned a 7-fold range, showing no correlation with shear, platelet or leukocyte count, or plasma concentrations of fibrinogen or von Willebrand factor. However, there was strong intra-individual correlation (r²=0.80; P<0.001) of thrombus deposition between carotid artery pairs. The wide variation in thrombotic response to a standardized stimulus, not accounted for by shear stress or typical hematological variables, appears to be an intrinsic propensity of the individual. The experimental system for thrombus generation is sufficiently quantitative for assessment of variables determining this propensity.

Key Words: thrombosis • vascular disease • risk factors

This article has been cited by other articles:

				C. Obi, W. Wysokinski, K. Karnicki, W. G. Owen, and R. D. McBane II Inhibition of Platelet-Rich Arterial Thrombus In Vivo: Acute Antithrombotic Effect of Intravenous HMG-CoA Reductase Therapy Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1271 - 1276. [Abstract] [Full Text] [PDF]

				R. D. McBane II Genetically Determined Procoagulant States and Heparin Use Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2003; 7(4): 427 - 442. [Abstract] [PDF]

				K. Karnicki, W. G. Owen, R. S. Miller, and R. D. McBane II Factors Contributing to Individual Propensity for Arterial Thrombosis Arterioscler Thromb Vasc Biol, September 1, 2002; 22(9): 1495 - 1499. [Abstract] [Full Text] [PDF]

				K. Karnicki, E. Komorowicz, D. N. Fass, W. G. Owen, and R. D. McBane II Influence of Anatomical Location on Arterial Thrombosis Arterioscler Thromb Vasc Biol, February 1, 2002; 22(2): 342 - 347. [Abstract] [Full Text] [PDF]

				A. G. Zaman, J. I. Osende, J. H. Chesebro, V. Fuster, A. Padurean, R. Gallo, S. G. Worthley, G. Helft, O. X. Rodriguez, J. T. Fallon, et al. In Vivo Dynamic Real-Time Monitoring and Quantification of Platelet-Thrombus Formation : Use of a Local Isotope Detector Arterioscler Thromb Vasc Biol, March 1, 2000; 20(3): 860 - 865. [Abstract] [Full Text] [PDF]