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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:905-911.)
© 1997 American Heart Association, Inc.

Articles

In Vivo Transfer of Lipoprotein(a) Into Human Atherosclerotic Carotid Arterial Intima

Lars B. Nielsen; Marie L.M. Grønholdt; Torben V. Schroeder; Steen Stender; ; Børge G. Nordestgaard

From the Departments of Clinical Biochemistry (L.B.N.) and Vascular Surgery (M.L.M.G., T.V.S.), Rigshospitalet, and the Department of Clinical Biochemistry, Herlev Hospital (B.G.N.), University of Copenhagen; and the Clinical Institute, University of Odense (S.S.), Denmark.

Abstract The aim of this study was to compare the atherogenic potential of lipoprotein(a) [Lp(a)] and LDL by measuring the intimal clearance of these two plasma lipoproteins in the atherosclerotic intima of the human carotid artery in vivo. Autologous ¹³¹I-Lp(a) and ¹²⁵I-LDL were mixed and reinjected intravenously 3 hours before elective surgical removal of the arterial intima in four patients. The intimal clearance of Lp(a) and LDL was 229±48 and 405±127 nL/cm² per hour, respectively (paired t test; P=.12). The mass accumulation of Lp(a) (114±32 ng/cm² per hour) was on average one 15th that of LDL (paired t test; P=.06), mainly reflecting a low plasma concentration of Lp(a) compared with LDL in the human subjects studied. In accordance with our previous observation in rabbits, there was a positive association between the intimal clearance of LDL and that of Lp(a) (r=.97, P=.03). Accordingly, high plasma levels of Lp(a) may share with LDL the potential for causing lipid accumulation in the arterial intima in humans.

Key Words: lipoprotein(a) • arterial wall • atherosclerosis

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