Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:3392-3398
© 1997 American Heart Association, Inc.
Articles |
Soy Isoflavones Improve Systemic Arterial Compliance but Not Plasma Lipids in Menopausal and Perimenopausal Women
From Baker Medical Research Institute, Melbourne, Australia (P.J.N., T.Y., T.S., S.P., A.D., P.K.), and CSIRO Division of Human Nutrition, Adelaide, Australia (A.O., M.A.).
Correspondence to Dr P. J. Nestel, Baker Medical Research Institute, Commercial Rd, Prahran VIC 3181, Australia (PO Box 348).
Abstract The possibility that the heightened cardiovascular risk associated with the menopause, which is said to be ameliorated by soybeans, can be reduced with soy isoflavones was tested in 21 women. Although several were perimenopausal, all have been included. A placebo-controlled crossover trial tested the effects of 80-mg daily isoflavones (45 mg genistein) over 5- to 10-week periods. Systemic arterial compliance (arterial elasticity), which declined with age in this group, improved 26% (P<.001) compared with placebo. Arterial pressure and plasma lipids were unaffected. The vasodilatory capacity of the microcirculation was measured in nine women; high acetylcholine-mediated dilation in the forearm vasculature was similar with active and placebo treatments. LDL oxidizability measured in vitro was unchanged. Thus, one important measure of arterial health, systemic arterial compliance, was significantly improved in perimenopausal and menopausal women taking soy isoflavones to about the same extent as is achieved with conventional hormone replacement therapy.
Key Words: genistein • menopause • women • flavonoids
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K. E Wangen, A. M Duncan, X. Xu, and M. S Kurzer Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women Am. J. Clinical Nutrition, February 1, 2001; 73(2): 225 - 231. [Abstract] [Full Text] [PDF]
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J. W. Erdman Jr Soy Protein and Cardiovascular Disease : A Statement for Healthcare Professionals From the Nutrition Committee of the AHA Circulation, November 14, 2000; 102(20): 2555 - 2559. [Full Text] [PDF]
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S. Lamon-Fava Genistein Activates Apolipoprotein A-I Gene Expression in the Human Hepatoma Cell Line Hep G2 J. Nutr., October 1, 2000; 130(10): 2489 - 2492. [Abstract] [Full Text]
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Y. Arai, S. Watanabe, M. Kimira, K. Shimoi, R. Mochizuki, and N. Kinae Dietary Intakes of Flavonols, Flavones and Isoflavones by Japanese Women and the Inverse Correlation between Quercetin Intake and Plasma LDL Cholesterol Concentration J. Nutr., September 1, 2000; 130(9): 2243 - 2250. [Abstract] [Full Text]
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M. R. Peluso, T. A. Winters, M. F. Shanahan, and W. J. Banz A Cooperative Interaction between Soy Protein and Its Isoflavone-Enriched Fraction Lowers Hepatic Lipids in Male Obese Zucker Rats and Reduces Blood Platelet Sensitivity in Male Sprague-Dawley Rats J. Nutr., September 1, 2000; 130(9): 2333 - 2342. [Abstract] [Full Text]
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J. Yamakoshi, M. K. Piskula, T. Izumi, K. Tobe, M. Saito, S. Kataoka, A. Obata, and M. Kikuchi Isoflavone Aglycone-Rich Extract without Soy Protein Attenuates Atherosclerosis Development in Cholesterol-Fed Rabbits J. Nutr., August 1, 2000; 130(8): 1887 - 1893. [Abstract] [Full Text]
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B. E Merz-Demlow, A. M Duncan, K. E Wangen, X. Xu, T. P Carr, W. R Phipps, and M. S Kurzer Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1462 - 1469. [Abstract] [Full Text] [PDF]
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E. L. Ashton, F. S. Dalais, and M. J. Ball Effect of Meat Replacement by Tofu on CHD Risk Factors Including Copper Induced LDL Oxidation J. Am. Coll. Nutr., June 1, 2000; 19(6): 761 - 767. [Abstract] [Full Text] [PDF]
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K. A. Greaves, M. D. Wilson, L. L. Rudel, J. K. Williams, and J. D. Wagner Consumption of Soy Protein Reduces Cholesterol Absorption Compared to Casein Protein Alone or Supplemented with an Isoflavone Extract or Conjugated Equine Estrogen in Ovariectomized Cynomolgus Monkeys J. Nutr., April 1, 2000; 130(4): 820 - 826. [Abstract] [Full Text]
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M. S. Anthony Soy and Cardiovascular Disease: Cholesterol Lowering and Beyond J. Nutr., March 1, 2000; 130(3): 662 - 662. [Full Text]
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Oral Presentation Abstracts J. Nutr., March 1, 2000; 130(3): 666 - 666. [Full Text]
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Poster Presentation Abstracts J. Nutr., March 1, 2000; 130(3): 680 - 680. [Full Text]
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K. Sudhir and P. A. Komesaroff Cardiovascular Actions of Estrogens in Men J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3411 - 3415. [Full Text] [PDF]
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J. R. Crouse III, T. Morgan, J. G. Terry, J. Ellis, M. Vitolins, and G. L. Burke A Randomized Trial Comparing the Effect of Casein With That of Soy Protein Containing Varying Amounts of Isoflavones on Plasma Concentrations of Lipids and Lipoproteins Arch Intern Med, September 27, 1999; 159(17): 2070 - 2076. [Abstract] [Full Text] [PDF]
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K. A. Greaves, J. S. Parks, J. K. Williams, and J. D. Wagner Intact Dietary Soy Protein, but Not Adding an Isoflavone-Rich Soy Extract to Casein, Improves Plasma Lipids in Ovariectomized Cynomolgus Monkeys J. Nutr., August 1, 1999; 129(8): 1585 - 1592. [Abstract] [Full Text]
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J. W. Anderson and T. J. Hanna Impact of Nondigestible Carbohydrates on Serum Lipoproteins and Risk for Cardiovascular Disease J. Nutr., July 1, 1999; 129(7): 1457 - 1457. [Abstract] [Full Text]
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 P. FANTI, B. P. SAWAYA, L. J. CUSTER, and A. A. FRANKE Serum Levels and Metabolic Clearance of the Isoflavones Genistein and Daidzein in Hemodialysis Patients J. Am. Soc. Nephrol., April 1, 1999; 10(4): 864 - 871. [Abstract] [Full Text]
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P. J. Nestel, S. Pomeroy, S. Kay, P. Komesaroff, J. Behrsing, J. D. Cameron, and L. West Isoflavones from Red Clover Improve Systemic Arterial Compliance But Not Plasma Lipids in Menopausal Women J. Clin. Endocrinol. Metab., March 1, 1999; 84(3): 895 - 898. [Abstract] [Full Text]
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A. H. Lichtenstein Soy Protein, Isoflavones and Cardiovascular Disease Risk J. Nutr., October 1, 1998; 128(10): 1589 - 1592. [Abstract] [Full Text]
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