Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:3159-3163
© 1997 American Heart Association, Inc.
Articles |
Antibodies Against Cardiolipin and Oxidatively Modified LDL in 50-Year-Old Men Predict Myocardial Infarction
From the Immunological Research Laboratory and Department of Medicine, Karolinska Institute, Stockholm (R.W., S.N., G.H., A.K.L.); and the Department of Geriatrics, University of Uppsala, Uppsala, Sweden (L.B., H.L.).
Correspondence to Ann Kari Lefvert, MD, PhD, Department of Medicine, Karolinska Institute, S-17176 Stockholm, Sweden. E-mail Ann.Kari.Lefvert{at}cmm.ki.se
Abstract Autoantibodies against oxidatively modified low-density lipoproteins (oxLDL) and cardiolipin occur in patients with vascular diseases, including atherosclerosis. The ability of such antibodies to predict myocardial infarction (MI) was investigated in a prospective nested case-control study in which healthy 50-year-old men were followed up for 20 years. Raised levels of antibodies against oxLDL and cardiolipin at 50 years of age correlated positively with the incidence of MI and mortality related to MI 10 to 20 years later. IgG and IgA antibodies against cardiolipin were associated with MI between 50 to 60 years of age and IgG and IgA antibodies against oxLDL with MI at 60 to 70 years of age. Moreover, higher antibody levels were noted in those who died from acute MI in comparison to those who survived. The predictive power of IgA and IgG antibodies was strong and largely independent of that of other strong risk factors. In conclusion, raised levels of antibodies against oxLDL and cardiolipin may predict MI and MI-related death.
Key Words: autoantibodies • oxidized LDL • cardiolipin • phospholipids • myocardial infarction
This article has been cited by other articles:
 |
|
 |
|
  T. P. Greco, A. M. Conti-Kelly, T. Greco Jr, R. Doyle, E. Matsuura, J. R. Anthony, and L. R. Lopez Newer Antiphospholipid Antibodies Predict Adverse Outcomes in Patients With Acute Coronary Syndrome Am J Clin Pathol, October 1, 2009; 132(4): 613 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Tomkin Targets for Intervention in Dyslipidemia in Diabetes Diabetes Care, February 1, 2008; 31(Supplement_2): S241 - S248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Ginsburg Regression of Atherosclerosis With Therapeutic Antibodies: Pipe Cleaner or Pipe Dream? J. Am. Coll. Cardiol., December 11, 2007; 50(24): 2319 - 2321. [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Dimayuga, X. Zhao, J. Yano, and K.-Y. Chyu Changes in immune responses to oxidized LDL epitopes during aging in hypercholesterolemic apoE(-/-) mice Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1644 - R1650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M McMahon, J Grossman, W Chen, and B H Hahn Inflammation and the pathogenesis of atherosclerosis in systemic lupus erythematosus Lupus, November 1, 2006; 15(11_suppl): 59 - 69. [Abstract] [PDF]
|
|
|
|
|
|
A Sinclair and R Baildon Mycophenolate mofetil: an overview Lupus, November 1, 2006; 15(11_suppl): 70 - 77. [PDF]
|
|
|
|
 |
|
 A.-K. L. Robertson and G. K Hansson T Cells in Atherogenesis: For Better or For Worse? Arterioscler Thromb Vasc Biol, November 1, 2006; 26(11): 2421 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. N. Bruce 'Not only...but also': factors that contribute to accelerated atherosclerosis and premature coronary heart disease in systemic lupus erythematosus Rheumatology, December 1, 2005; 44(12): 1492 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kahles, M. Humpich, H. Steinmetz, M. Sitzer, and E. Lindhoff-Last Phosphatidylserine IgG and beta-2-glycoprotein I IgA antibodies may be a risk factor for ischaemic stroke Rheumatology, September 1, 2005; 44(9): 1161 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Goncalves, M.-L. M. Gronholdt, I. Soderberg, M. P.S. Ares, B. G. Nordestgaard, J. F. Bentzon, G. N. Fredrikson, and J. Nilsson Humoral Immune Response Against Defined Oxidized Low-Density Lipoprotein Antigens Reflects Structure and Disease Activity of Carotid Plaques Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1250 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jimenez, M. A. Garcia-Criado, D. Tassies, J. C. Reverter, R. Cervera, M. R. Gilabert, D. Zambon, E. Ros, C. Bru, and J. Font Preclinical vascular disease in systemic lupus erythematosus and primary antiphospholipid syndrome Rheumatology, June 1, 2005; 44(6): 756 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Tinahones, J. M. Gomez-Zumaquero, L. Garrido-Sanchez, E. Garcia-Fuentes, G. Rojo-Martinez, I. Esteva, M. S. R. de Adana, F. Cardona, and F. Soriguer Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population J. Lipid Res., March 1, 2005; 46(3): 452 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Pussinen, T. Vilkuna-Rautiainen, G. Alfthan, T. Palosuo, M. Jauhiainen, J. Sundvall, M. Vesanen, K. Mattila, and S. Asikainen Severe Periodontitis Enhances Macrophage Activation via Increased Serum Lipopolysaccharide Arterioscler Thromb Vasc Biol, November 1, 2004; 24(11): 2174 - 2180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shoenfeld, R. Wu, L. D. Dearing, and E. Matsuura Are Anti-Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective? Circulation, October 26, 2004; 110(17): 2552 - 2558. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Gomez-Zumaquero, F. J. Tinahones, E. De Ramon, M. Camps, L. Garrido, and F. J. Soriguer Association of biological markers of activity of systemic lupus erythematosus with levels of anti-oxidized low-density lipoprotein antibodies Rheumatology, April 1, 2004; 43(4): 510 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R L Brey, J Chapman, S R Levine, G Ruiz-Irastorza, R H. Derksen, M Khamashta, and Y Shoenfeld Stroke and the antiphospholipid syndrome: consensus meeting Taormina 2002 Lupus, July 1, 2003; 12(7): 508 - 513. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Galli, D. Luciani, G. Bertolini, and T. Barbui Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature Blood, March 1, 2003; 101(5): 1827 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Maslowski, R. McBane, P. Alexewicz, and W. E Wysokinski Antiphospholipid antibodies in thromboangiitis obliterans Vascular Medicine, November 1, 2002; 7(4): 259 - 264. [Abstract] [PDF]
|
|
|
|
 |
|
 R. L. Brey, C. L. Stallworth, D. L. McGlasson, M. A. Wozniak, R. J. Wityk, B. J. Stern, M. A. Sloan, R. Sherwin, T. R. Price, R. F. Macko, et al. Antiphospholipid Antibodies and Stroke in Young Women * Editorial Comment Stroke, October 1, 2002; 33(10): 2396 - 2401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Cvetkovic, S. Wallberg-Jonsson, E. Ahmed, S. Rantapaa-Dahlqvist, and A. K. Lefvert Increased levels of autoantibodies against copper-oxidized low density lipoprotein, malondialdehyde-modified low density lipoprotein and cardiolipin in patients with rheumatoid arthritis Rheumatology, September 1, 2002; 41(9): 988 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. K. Hansson, P. Libby, U. Schonbeck, and Z.-Q. Yan Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis Circ. Res., August 23, 2002; 91(4): 281 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. I. Jennekens and L. Kater The central nervous system in systemic lupus erythematosus. Part 2. Pathogenetic mechanisms of clinical syndromes: a literature investigation Rheumatology, June 1, 2002; 41(6): 619 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Sherer and Y Shoenfeld Atherosclerosis Ann Rheum Dis, February 1, 2002; 61(2): 97 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Brey, R. D. Abbott, J. D. Curb, D. S. Sharp, G. W. Ross, C. L. Stallworth, and S. J. Kittner {beta}2-Glycoprotein 1-Dependent Anticardiolipin Antibodies and Risk of Ischemic Stroke and Myocardial Infarction: The Honolulu Heart Program Stroke, August 1, 2001; 32(8): 1701 - 1706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Inoue, T. Uchida, H. Kamishirado, K. Takayanagi, and S. Morooka Antibody against oxidized low density lipoprotein may predict progression or regression of atherosclerotic coronary artery disease J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1871 - 1876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Sargeant, E. K. Kahwa, R. J. Wilks, and A. K. Lefvert Re: Anticardiolipin Antibodies Are Not an Independent Risk Factor for Stroke Response Stroke, May 1, 2001; 32 (5): 1234 - 1237. [Full Text] [PDF]
|
|
|
|
|
|
T. Inoue, T. Uchida, H. Kamishirado, K. Takayanagi, T. Hayashi, and S. Morooka Clinical significance of antibody against oxidized low density lipoprotein in patients with atherosclerotic coronary artery disease J. Am. Coll. Cardiol., March 1, 2001; 37(3): 775 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ogawa, H. Soejima, K. Takazoe, S. Miyamoto, I. Kajiwara, H. Shimomura, T. Sakamoto, M. Yoshimura, K. Kugiyama, M. Kimura, et al. Increased Autoantibodies Against Oxidized Low-Density Lipoprotein in Coronary Circulation in Patients with Coronary Spastic Angina Angiology, March 1, 2001; 52(3): 167 - 174. [Abstract] [PDF]
|
|
|
|
|
|
D. Pratico, R. K. Tangirala, S. Horkko, J. L. Witztum, W. Palinski, and G. A. FitzGerald Circulating autoantibodies to oxidized cardiolipin correlate with isoprostane F2{alpha}-VI levels and the extent of atherosclerosis in ApoE-deficient mice: modulation by vitamin E Blood, January 15, 2001; 97(2): 459 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsimikas, W. Palinski, and J. L. Witztum Circulating Autoantibodies to Oxidized LDL Correlate With Arterial Accumulation and Depletion of Oxidized LDL in LDL Receptor-Deficient Mice Arterioscler Thromb Vasc Biol, January 1, 2001; 21(1): 95 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mustafa, S. Nityanand, L. Berglund, H. Lithell, and A. K. Lefvert Circulating Immune Complexes in 50-Year-Old Men as a Strong and Independent Risk Factor for Myocardial Infarction Circulation, November 21, 2000; 102(21): 2576 - 2581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bili, A. J. Moss, C. W. Francis, W. Zareba, L. F. M. Watelet, I. Sanz, f. t. T. Factors, and R. C. E. Investigators Anticardiolipin Antibodies and Recurrent Coronary Events : A Prospective Study of 1150 Patients Circulation, September 12, 2000; 102(11): 1258 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ahmed, B. Stegmayr, J. Trifunovic, L. Weinehall, G. Hallmans, and A. K. Lefvert Anticardiolipin Antibodies Are Not an Independent Risk Factor for Stroke : An Incident Case-Referent Study Nested Within the MONICA and Vasterbotten Cohort Project Stroke, June 1, 2000; 31(6): 1289 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. MANZI, M. C. M WASKO, and S. MANZI Inflammation-mediated rheumatic diseases and atherosclerosis Ann Rheum Dis, May 1, 2000; 59(5): 321 - 325. [Full Text]
|
|
|
|
|
|
S. Manzi Systemic lupus erythematosus: a model for atherogenesis? Rheumatology, April 1, 2000; 39(4): 353 - 359. [Full Text] [PDF]
|
|
|
|
|
|
S Manzi, L H Kuller, D Edmundowicz, and K Sutton-Tyrrell Vascular imaging: changing the face of cardiovascular research Lupus, March 1, 2000; 9(3): 176 - 182. [Abstract] [PDF]
|
|
|
|
|
|
O Vaarala Antibodies to oxidised LDL Lupus, March 1, 2000; 9(3): 202 - 205. [Abstract] [PDF]
|
|
|
|
|
|
A. T. Erkkila, O. Narvanen, S. Lehto, M. I. J. Uusitupa, and S. Yla-Herttuala Autoantibodies Against Oxidized Low-Density Lipoprotein and Cardiolipin in Patients With Coronary Heart Disease Arterioscler Thromb Vasc Biol, January 1, 2000; 20(1): 204 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ahmed, J. Trifunovic, B. Stegmayr, G. Hallmans, and A. K. Lefvert Autoantibodies Against Oxidatively Modified LDL Do Not Constitute a Risk Factor for Stroke : A Nested Case-Control Study Stroke, December 1, 1999; 30(12): 2541 - 2546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Vaarala Review : Antiphospholipid antibodies and myocardial infarction Lupus, January 1, 1998; 7(2_suppl): S132 - S134. [Abstract] [PDF]
|
|