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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:2880-2884.)
© 1997 American Heart Association, Inc.

Articles

The Apolipoprotein E and ß-Fibrinogen G/A-455 Gene Polymorphisms Are Associated With Ischemic Stroke Involving Large-Vessel Disease

Christof Kessler; Carsten Spitzer; Dorothea Stauske; Sabine Mende; Jörg Stadlmüller; Reinhard Walther; ; Rainer Rettig

From the Department of Neurology (C.S., C.K.), Institute of Clinical Chemistry (D.S.), Institute of Physiology (S.M., R.R.), and Institute of Biochemistry (R.W.), Ernst-Moritz-Arndt-University, Greifswald, and the Technology Transfer Unit Biotechnology (J.S., R.W.), Greifswald, Germany.

Correspondence to Christof Kessler, Department of Neurology, Ernst-Moritz-Arndt-University, Ellernholzstrasse 1/2, 17487 Greifswald, Germany. E-mail kessler{at}neurologie.uni-greifswald.de

Abstract The relationship between the apolipoprotein E (apoE) and ß-fibrinogen G/A-455 polymorphisms and cerebrovascular disease (CVD) was examined in the present study. We compared 227 patients with the subtypes of CVD (large-vessel disease, lacunar stroke, cardiac embolism, or undetermined pathomechanisms) with 225 control subjects. The occurrence of apoE isoforms (E2, E3, and E4) and the ß-fibrinogen G/A-455 genotype was determined in these individuals. No differences in apoE polymorphisms or allele frequencies between the CVD patients and control subjects were found. However, analysis of apoE genotypes as a function of stroke subtype revealed that the apoE4 allele was significantly more common in those patients with macroangiopathy-associated CVD. The only CVD risk factor that distinguished patients with the E4 allele from those with other apoE genotypes was elevated cholesterol. No association between the ß-fibrinogen G/A-455 polymorphism and CVD was found. However, homozygosity for the A allele was more common in patients with CVD resulting from large-vessel disease. These data demonstrate that the apoE4 allele and the AA genotype of the ß-fibrinogen G/A-455 polymorphism occur significantly more frequently in patients with CVD resulting from stenosis of large, brain-supplying vessels. Such genetic analyses may further our understanding of the etiology of cerebrovascular disease.

Key Words: stroke • genetics • apoE • ß-fibrinogen • polymorphisms

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