Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:2238-2244
© 1997 American Heart Association, Inc.
Articles |
Remodeling With Neointima Formation in the Mouse Carotid Artery After Cessation of Blood Flow
From Pharmacia and Upjohn, Cardiovascular Pharmacology, Kalamazoo, Mich (A.K.), and the Department of Surgery, Maine Medical Center Research Institute, South Portland, ME (V.L.).
Correspondence to Volkhard Lindner, MD, PhD, Maine Medical Center Research Institute, 125 John Roberts Rd, Suite 8, South Portland, ME 04106. E-mail lindnv{at}poa.mmc.org
Abstract The ability of gene targeting in the mouse species
presents a powerful tool to determine the role of specific
molecules in vascular biology. Using a denuding-injury procedure, we
recently reported that intimal lesions can be induced in the carotid
artery of outbred mice. The technical challenge associated with
achieving complete denudation and the relatively small size of the
developing lesions prompted us to design the present model of
neointima formation and vascular remodeling in the carotid
artery of the inbred FVB mouse strain. Complete ligation of the vessel
near the carotid bifurcation induced rapid proliferation of medial
smooth muscle cells, leading to extensive neointima
formation in the presence of an endothelial lining.
Thrombus formation was not observed except in the most distal part of
the vessel adjacent to the ligature. At 4 weeks after ligation, luminal
area was reduced by 
80% through a combination of decreased vessel
diameter and neointima formation. Ultrastructural
analysis provided evidence for cell death in the developing
neointima as well as the remodeling media. The present
model might be useful in identifying those genes important for
neointima formation and vascular remodeling.
Key Words: smooth muscle • endothelium • intimal hyperplasia • mice
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Z. S. Galis, C. Johnson, D. Godin, R. Magid, J. M. Shipley, R. M. Senior, and E. Ivan Targeted Disruption of the Matrix Metalloproteinase-9 Gene Impairs Smooth Muscle Cell Migration and Geometrical Arterial Remodeling Circ. Res., November 1, 2002; 91(9): 852 - 859. [Abstract] [Full Text] [PDF]
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N. Murakoshi, T. Miyauchi, Y. Kakinuma, T. Ohuchi, K. Goto, M. Yanagisawa, and I. Yamaguchi Vascular Endothelin-B Receptor System In Vivo Plays a Favorable Inhibitory Role in Vascular Remodeling After Injury Revealed by Endothelin-B Receptor-Knockout Mice Circulation, October 8, 2002; 106(15): 1991 - 1998. [Abstract] [Full Text] [PDF]
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R. Kraemer Reduced Apoptosis and Increased Lesion Development in the Flow-Restricted Carotid Artery of p75NTR-Null Mutant Mice Circ. Res., September 20, 2002; 91(6): 494 - 500. [Abstract] [Full Text] [PDF]
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E. K. Arkenbout, V. de Waard, M. van Bragt, T. A.E. van Achterberg, J. M. Grimbergen, B. Pichon, H. Pannekoek, and C. J.M. de Vries Protective Function of Transcription Factor TR3 Orphan Receptor in Atherogenesis: Decreased Lesion Formation in Carotid Artery Ligation Model in TR3 Transgenic Mice Circulation, September 17, 2002; 106(12): 1530 - 1535. [Abstract] [Full Text] [PDF]
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C. J. Sullivan and J. B. Hoying Flow-Dependent Remodeling in the Carotid Artery of Fibroblast Growth Factor-2 Knockout Mice Arterioscler Thromb Vasc Biol, July 1, 2002; 22(7): 1100 - 1105. [Abstract] [Full Text] [PDF]
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Y. Yuan, L. Liao, D. A. Tulis, and J. Xu Steroid Receptor Coactivator-3 Is Required for Inhibition of Neointima Formation by Estrogen Circulation, June 4, 2002; 105(22): 2653 - 2659. [Abstract] [Full Text] [PDF]
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E. Ivan, J. J. Khatri, C. Johnson, R. Magid, D. Godin, S. Nandi, S. Lessner, and Z. S. Galis Expansive Arterial Remodeling Is Associated With Increased Neointimal Macrophage Foam Cell Content: The Murine Model of Macrophage-Rich Carotid Artery Lesions Circulation, June 4, 2002; 105(22): 2686 - 2691. [Abstract] [Full Text] [PDF]
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L. Peng, N. Bhatia, A. C. Parker, Y. Zhu, and W. P. Fay Endogenous Vitronectin and Plasminogen Activator Inhibitor-1 Promote Neointima Formation in Murine Carotid Arteries Arterioscler Thromb Vasc Biol, June 1, 2002; 22(6): 934 - 939. [Abstract] [Full Text] [PDF]
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D. G. Kuhel, B. Zhu, D. P. Witte, and D. Y. Hui Distinction in Genetic Determinants for Injury-Induced Neointimal Hyperplasia and Diet-Induced Atherosclerosis in Inbred Mice Arterioscler Thromb Vasc Biol, June 1, 2002; 22(6): 955 - 960. [Abstract] [Full Text] [PDF]
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S. M. Lessner, H. L. Prado, E. K. Waller, and Z. S. Galis Atherosclerotic Lesions Grow Through Recruitment and Proliferation of Circulating Monocytes in a Murine Model Am. J. Pathol., June 1, 2002; 160(6): 2145 - 2155. [Abstract] [Full Text] [PDF]
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M. D. Layne, S.-F. Yet, K. Maemura, C.-M. Hsieh, X. Liu, B. Ith, M.-E. Lee, and M. A. Perrella Characterization of the Mouse Aortic Carboxypeptidase-Like Protein Promoter Reveals Activity in Differentiated and Dedifferentiated Vascular Smooth Muscle Cells Circ. Res., April 5, 2002; 90(6): 728 - 736. [Abstract] [Full Text] [PDF]
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H. Konishi, Y. Katoh, N. Takaya, Y. Kashiwakura, S. Itoh, C. Ra, and H. Daida Platelets Activated by Collagen Through Immunoreceptor Tyrosine-Based Activation Motif Play Pivotal Role in Initiation and Generation of Neointimal Hyperplasia After Vascular Injury Circulation, February 26, 2002; 105(8): 912 - 916. [Abstract] [Full Text] [PDF]
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T. Tolbert, J. A. Thompson, P. Bouchard, and S. Oparil Estrogen-Induced Vasoprotection Is Independent of Inducible Nitric Oxide Synthase Expression: Evidence From the Mouse Carotid Artery Ligation Model Circulation, November 27, 2001; 104(22): 2740 - 2745. [Abstract] [Full Text] [PDF]
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M. Sata, S. Sugiura, M. Yoshizumi, Y. Ouchi, Y. Hirata, and R. Nagai Acute and Chronic Smooth Muscle Cell Apoptosis After Mechanical Vascular Injury Can Occur Independently of the Fas-Death Pathway Arterioscler Thromb Vasc Biol, November 1, 2001; 21(11): 1733 - 1737. [Abstract] [Full Text] [PDF]
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H. Weiler, V. Lindner, B. Kerlin, B. H. Isermann, S. B. Hendrickson, B. C. Cooley, D. A. Meh, M. W. Mosesson, N. W. Shworak, M. J. Post, et al. Characterization of a Mouse Model for Thrombomodulin Deficiency Arterioscler Thromb Vasc Biol, September 1, 2001; 21(9): 1531 - 1537. [Abstract] [Full Text] [PDF]
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S. S. Smyth, E. D. Reis, W. Zhang, J. T. Fallon, R. E. Gordon, and B. S. Coller {beta}3-Integrin-Deficient Mice but Not P-Selectin-Deficient Mice Develop Intimal Hyperplasia After Vascular Injury : Correlation With Leukocyte Recruitment to Adherent Platelets 1 Hour After Injury Circulation, May 22, 2001; 103(20): 2501 - 2507. [Abstract] [Full Text] [PDF]
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J. A. McPherson, K. G. Barringhaus, G. G. Bishop, J. M. Sanders, J. M. Rieger, S. E. Hesselbacher, L. W. Gimple, E. R. Powers, T. Macdonald, G. Sullivan, et al. Adenosine A2A Receptor Stimulation Reduces Inflammation and Neointimal Growth in a Murine Carotid Ligation Model Arterioscler Thromb Vasc Biol, May 1, 2001; 21(5): 791 - 796. [Abstract] [Full Text] [PDF]
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T. Kawasaki, M. Dewerchin, H. R. Lijnen, I. Vreys, J. Vermylen, and M. F. Hoylaerts Mouse Carotid Artery Ligation Induces Platelet-Leukocyte-Dependent Luminal Fibrin, Required for Neointima Development Circ. Res., February 2, 2001; 88(2): 159 - 166. [Abstract] [Full Text] [PDF]
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S. Kawashima, T. Yamashita, M. Ozaki, Y. Ohashi, H. Azumi, N. Inoue, K.-i. Hirata, Y. Hayashi, H. Itoh, and M. Yokoyama Endothelial NO Synthase Overexpression Inhibits Lesion Formation in Mouse Model of Vascular Remodeling Arterioscler Thromb Vasc Biol, February 1, 2001; 21(2): 201 - 207. [Abstract] [Full Text] [PDF]
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D. Godin, E. Ivan, C. Johnson, R. Magid, and Z. S. Galis Remodeling of Carotid Artery Is Associated With Increased Expression of Matrix Metalloproteinases in Mouse Blood Flow Cessation Model Circulation, December 5, 2000; 102(23): 2861 - 2866. [Abstract] [Full Text] [PDF]
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J. E. Rectenwald, L. L. Moldawer, T. S. Huber, J. M. Seeger, and C. K. Ozaki Direct Evidence for Cytokine Involvement in Neointimal Hyperplasia Circulation, October 3, 2000; 102(14): 1697 - 1702. [Abstract] [Full Text] [PDF]
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J. L. Hall, C. M. Matter, X. Wang, and G. H. Gibbons Hyperglycemia Inhibits Vascular Smooth Muscle Cell Apoptosis Through a Protein Kinase C-Dependent Pathway Circ. Res., September 29, 2000; 87(7): 574 - 580. [Abstract] [Full Text] [PDF]
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J. M. Miano and B. C. Berk Retinoids : Versatile Biological Response Modifiers of Vascular Smooth Muscle Phenotype Circ. Res., September 1, 2000; 87(5): 355 - 362. [Full Text] [PDF]
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A. A.-R. Higazi, T. Nassar, T. Ganz, D. J. Rader, R. Udassin, K. Bdeir, E. Hiss, B. S. Sachais, K. J. Williams, E. Leitersdorf, et al. The alpha -defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis Blood, August 15, 2000; 96(4): 1393 - 1398. [Abstract] [Full Text] [PDF]
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C. Emanueli, M. B. Salis, J. Chao, L. Chao, J. Agata, K.-F. Lin, A. Munao, S. Straino, A. Minasi, M. C. Capogrossi, et al. Adenovirus-Mediated Human Tissue Kallikrein Gene Delivery Inhibits Neointima Formation Induced by Interruption of Blood Flow in Mice Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1459 - 1466. [Abstract] [Full Text] [PDF]
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K. J. Harmon, L. L. Couper, and V. Lindner Strain-Dependent Vascular Remodeling Phenotypes in Inbred Mice Am. J. Pathol., May 1, 2000; 156(5): 1741 - 1748. [Abstract] [Full Text] [PDF]
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P. M. H. Schiffers, D. Henrion, C. M. Boulanger, E. Colucci-Guyon, F. Langa-Vuves, H. van Essen, G. E. Fazzi, B. I. Levy, and J. G. R. De Mey Altered Flow-Induced Arterial Remodeling in Vimentin-Deficient Mice Arterioscler Thromb Vasc Biol, March 1, 2000; 20(3): 611 - 616. [Abstract] [Full Text] [PDF]
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M. Roque, J. T. Fallon, J. J. Badimon, W. X. Zhang, M. B. Taubman, and E. D. Reis Mouse Model of Femoral Artery Denudation Injury Associated With the Rapid Accumulation of Adhesion Molecules on the Luminal Surface and Recruitment of Neutrophils Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 335 - 342. [Abstract] [Full Text] [PDF]
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N. J. McCarthy and M. Bennett The regulation of vascular smooth muscle cell apoptosis Cardiovasc Res, February 1, 2000; 45(3): 747 - 755. [Abstract] [Full Text] [PDF]
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C. Shi, A. Patel, D. Zhang, H. Wang, P. Carmeliet, G. L. Reed, M.-E. Lee, E. Haber, and N. E. S. Sibinga Plasminogen Is Not Required for Neointima Formation in a Mouse Model of Vein Graft Stenosis Circ. Res., April 30, 1999; 84(8): 883 - 890. [Abstract] [Full Text] [PDF]
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S. R. Bryant, R. J. Bjercke, D. A. Erichsen, A. Rege, and V. Lindner Vascular Remodeling in Response to Altered Blood Flow Is Mediated by Fibroblast Growth Factor-2 Circ. Res., February 19, 1999; 84(3): 323 - 328. [Abstract] [Full Text] [PDF]
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M. R Bennett Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture Cardiovasc Res, February 1, 1999; 41(2): 361 - 368. [Abstract] [Full Text] [PDF]
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