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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:2054-2060.)
© 1997 American Heart Association, Inc.

Articles

Heritability Analysis of Lipids and Three Gene Loci in Twins Link the Macrophage Scavenger Receptor to HDL Cholesterol Concentrations

Hans Knoblauch; Andreas Busjahn; Sylvia Münter; Zsuzsanna Nagy; Hans-Dieter Faulhaber; Herbert Schuster; ; Friedrich C. Luft

From the Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, Berlin, Germany.

Correspondence to Friedrich C. Luft, MD, Franz Volhard Clinic, Wiltbergstrasse 50, 13122 Berlin, Germany. E-mail fcluft{at}mdc-berlin.de

Abstract We studied 100 healthy monozygotic and 72 dizygotic twin pairs (mean age, 34±14 years) to test for genetic influences on blood lipids and to examine relevant gene loci. Total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglyceride (TG) levels were determined after a 12-hour fast. Zygosity was determined with the use of microsatellite markers. Heritability estimates were conducted by using the lisrel 8 program; a sib-pair analysis was conducted by using the sibpal program. Linear regression analyses were carried out between identical-by-descent status and squared within-pair differences of TC, LDL-C, HDL-C, and TG values. Heritability estimates of the lipid serum concentrations ranged from.58 to.66. A significant linkage relationship was found for HDL-C (P=.008) and TGs (P=.05) with D8S261 on chromosome 8p. However, no linkage was found between any of the lipid variables and the lipoprotein lipase gene locus (LPL GZ14/15 and D8S282). Because D8S261 is located approximately halfway between the LPL and macrophage scavenger receptor genes, we examined the nearby markers D8S549 and D8S1731. Linkage was found for HDL-C and D8S549 (P=.001) and for HDL-C and D8S1731 (P=.04). On the other hand, we found no linkage between the LDL receptor gene locus and LDL-C serum concentrations nor between the LPL gene locus and the various other lipid fractions. Our data suggest a significant influence of the macrophage scavenger receptor gene locus on HDL-C and weak influence on TG levels. We suggest that inherited variability in the macrophage scavenger receptor gene has an influence on serum lipid concentrations.

Key Words: genetics • HDL cholesterol • lipoprotein lipase • LDL cholesterol • macrophage scavenger receptor

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