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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:51-55.)
© 1997 American Heart Association, Inc.

Articles

Factor VII, Cholesterol, and Triglycerides

The CARDIA Study

David Green; Mary Ann Chamberlain; Karen J. Ruth; Aaron R. Folsom; Kiang Liu

the Atherosclerosis Program, Department of Medicine, and the Department of Preventive Medicine, Northwestern University Medical School, Chicago, Ill, and the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis.

Correspondence to David Green, MD, PhD, 345 E Superior St, Room 1407, Chicago, IL 60611.

Cross-sectional studies have shown that factor VII coagulant activity (VII_c) is positively associated with plasma total cholesterol (TC), LDL cholesterol, and triglycerides (TG) as well as body mass index (BMI) and diastolic blood pressure. To determine whether changes in VII_c parallel changes in coronary risk factors over a period of 2 years, we examined data from 1514 participants in the Coronary Artery Risk Development in Young Adults Study (CARDIA), an ongoing investigation of lifestyles and evolution of cardiovascular risk factors. Subjects were 23 to 35 years old at the year 5 examination. Cross-sectional analyses at these examinations showed that VII_c was positively correlated (P<.001) with TC and TG in all race/sex groups except for TC in black women at the year 5 examination. Changes in VII_c over the 2-year period were correlated positively with changes in TC in all except black men and TG in all groups; the association of VII_c change with change in TC and TG was reduced only slightly with adjustment for age and BMI at year 5 and 2-year change in BMI. To determine whether the higher levels of VII_c in subjects with higher lipid values were due to activation of the factor or to an increase in the concentration of the factor VII clotting protein, we measured factor VII antigen (VII_ag) in a randomly selected subsample of 223 subjects at the year 7 examination. In all sex/race groups, VII_ag correlated with VII_c (r=.69 to 0.81). After adjustment for sex and race, the partial correlation coefficient between TG and VII_c was .28 (P=.0001); between TG and VII_ag, .35 (P=.0001); between TC and VII_c, .39 (P=.0001); and between TC and VII_ag, 0.43 (P=.0001). No associations were observed between lipid levels and the ratio of VII_c to VII_ag. We conclude that the raised VII_c with higher lipid levels occurs in blacks as well as whites, in men and women, persists over time, and represents a true increase in the plasma concentration of this clotting factor.

Key Words: factor VII • lipids • thrombosis risk factors

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