© 1996 American Heart Association, Inc.
Articles |
Population Correlates of Coagulation Factor VII
Importance of Age, Sex, and Menopausal Status as Determinants of Activated Factor VII
INSERM, Cardiovascular Epidemiology Unit U258, Hopital Broussais, Paris (P.-Y.S., R.A.), Laboratoire Serbio, Gennevilliers, (A.-M.V., P.B., J.A.), and Centre d'Investigations Preventives et Cliniques, Paris (J.-M.K., L.G.), France.
Correspondence to Dr Pierre-Yves Scarabin, INSERM–Cardiovascular Epidemiology Unit U258, Hopital Broussais, 96, rue Didot, 75674 Paris Cedex 14, France.
Factor VII coagulant activity (FVIIc) has been found to be related to cardiovascular risk factors and may be an independent predictor of coronary heart disease (CHD). Whether these associations are due to changes in FVII activation rather than FVII concentration remain unclear. Therefore, we investigated the relationships between activated factor VII (FVIIa) and CHD risk factors in healthy subjects (336 men and 348 women) aged 25 to 64 years. In addition to direct quantitation of FVIIa by use of a recombinant, truncated tissue factor, FVIIc and factor VII antigen (FVII:Ag) levels were measured by standard procedures. There were highly significant correlations between the three techniques of FVII assay (r>+.55). Plasma FVIIc and FVIIa levels increased with age in both sexes, but the rate of rise was significantly greater in women than men. At younger ages, mean values of FVIIc and FVIIa were significantly lower in women than men, whereas at older ages the reverse was observed. After adjustment for age, postmenopausal women had significantly higher mean levels of FVIIc and FVIIa than did premenopausal women. Hormone replacement therapy significantly reversed the rise in FVIIc in postmenopausal women, and a similar trend in FVIIa was also observed. Age-, sex-, and menopause-related changes in FVIIc were partly explained by a higher proportion of fully active FVII molecules, as indicated by significant differences in the FVIIa-to-FVII:Ag ratio. Oral contraceptive use was associated with high FVIIc levels, and this effect was mainly due to an increase in FVII:Ag. Levels of FVIIa were positively correlated with serum cholesterol concentrations in both sexes. There were no strong associations between FVIIa levels and other CHD risk factors, including smoking habits, alcohol consumption, blood pressure, obesity, glucose, triglycerides, and serum lipoprotein(a) concentrations. Multiple regression analysis showed independent effects of age and cholesterol levels on FVIIa in men, whereas age and menopausal status were the main predictors of FVIIa in women. Our results show that FVII activation is associated with CHD risk factors. These findings are consistent with a possible role for FVII in the pathogenesis of CHD. Furthermore, our data suggest that the dramatic rise in CHD incidence in postmenopausal women as well as the cardioprotective effect of estrogen may be mediated through FVII and blood coagulation.
Key Words: activated factor VII • factor VII coagulant activity • factor VII antigen • menopause • hormone replacement therapy
This article has been cited by other articles:
 |
|
 |
|
  M. R. Sowers, K. A. Matthews, M. Jannausch, J. F. Randolph, D. McConnell, K. Sutton-Tyrrell, R. Little, B. Lasley, and R. Pasternak Hemostatic Factors and Estrogen during the Menopausal Transition J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 5942 - 5948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. F. Godsland, D. Crook, A. J. Proudler, and J. C. Stevenson Hemostatic Risk Factors and Insulin Sensitivity, Regional Body Fat Distribution, and the Metabolic Syndrome J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 190 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.M. Bladbjerg, S.O. Skouby, L.F. Andersen, and J. Jespersen Effects of different progestin regimens in hormone replacement therapy on blood coagulation factor VII and tissue factor pathway inhibitor Hum. Reprod., December 1, 2002; 17(12): 3235 - 3241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Di Bitondo, A. J. Hall, I. R. Peake, L. Iacoviello, and P. R. Winship Oestrogenic repression of human coagulation factor VII expression mediated through an oestrogen response element sequence motif in the promoter region Hum. Mol. Genet., April 1, 2002; 11(7): 723 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Braunstein, D. W. Kershner, P. Bray, G. Gerstenblith, S. P. Schulman, W. S. Post, and R. S. Blumenthal Interaction of Hemostatic Genetics With Hormone Therapy : New Insights To Explain Arterial Thrombosis in Postmenopausal Women Chest, March 1, 2002; 121(3): 906 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Alexander, L. K. Newby, A. S. Hellkamp, R. A. Harrington, E. D. Peterson, S. Kopecky, A. Langer, P. O'Gara, C. M. O'Connor, R. N. Daly, et al. Initiation of hormone replacement therapy after acute myocardial infarction is associated with more cardiac events during follow-up J. Am. Coll. Cardiol., July 1, 2001; 38(1): 1 - 7. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Pernerstorfer, P. Stohlawetz, U. Hollenstein, L. Dzirlo, H.-G. Eichler, S. Kapiotis, B. Jilma, and W. Speiser Endotoxin-Induced Activation of the Coagulation Cascade in Humans : Effect of Acetylsalicylic Acid and Acetaminophen Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2517 - 2523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. S. Ariens, H. P. Kohler, M. W. Mansfield, and P. J. Grant Subunit Antigen and Activity Levels of Blood Coagulation Factor XIII in Healthy Individuals : Relation to Sex, Age, Smoking, and Hypertension Arterioscler Thromb Vasc Biol, August 1, 1999; 19(8): 2012 - 2016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Sanders, T. de Grassi, G. J Miller, and S. E Humphries Dietary oleic and palmitic acids and postprandial factor VII in middle-aged men heterozygous and homozygous for factor VII R353Q polymorphism Am. J. Clinical Nutrition, February 1, 1999; 69(2): 220 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Mennen, M. de Maat, G. Meijer, P. Zock, D. Grobbee, F. Kok, C. Kluft, and E. Schouten Factor VIIa Response to a Fat-Rich Meal Does Not Depend on Fatty Acid Composition : A Randomized Controlled Trial Arterioscler Thromb Vasc Biol, April 1, 1998; 18(4): 599 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-Y. Scarabin, M. Alhenc-Gelas, G. Plu-Bureau, P. Taisne, R. Agher, and M. Aiach Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Blood Coagulation and Fibrinolysis in Postmenopausal Women : A Randomized Controlled Trial Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 3071 - 3078. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Kapiotis, B. Jilma, P. Quehenberger, K. Ruzicka, S. Handler, and W. Speiser Morning Hypercoagulability and Hypofibrinolysis : Diurnal Variations in Circulating Activated Factor VII, Prothrombin Fragment F1+2, and Plasmin–Plasmin Inhibitor Complex Circulation, July 1, 1997; 96(1): 19 - 21. [Abstract] [Full Text]
|
|