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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1996;16:1430-1436.)
© 1996 American Heart Association, Inc.

Articles

Relationship of Plasma Cholesteryl Ester Transfer Protein to HDL Cholesterol

Studies in Normotriglyceridemia and Moderate Hypertriglyceridemia

Bernhard Foger; Andreas Ritsch; Alfred Doblinger; Holger Wessels; Josef R. Patsch

the Department of Internal Medicine, University of Innsbruck, Austria (B.F., A.R., A.D., J.R.P.), and the Department of Education, University of Berlin, Germany (H.W.).

Correspondence to Bernhard Foger, MD, Department of Internal Medicine, University of Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria.

To evaluate the independent effect of cholesteryl ester transfer protein (CETP) on HDL concentrations in humans, we measured lipids, lipoproteins, postprandial lipemia after an oral fat load, CETP mass, and the activities of CETP, lipoprotein lipase (LPL), and hepatic lipase in 16 healthy, normotriglyceridemic men and in 23 men with moderate, primary hypertriglyceridemia on an American Heart Association Step I diet. Fasting triglycerides and postprandial lipemia were increased and HDL cholesterol (HDL-C) was decreased in hypertriglyceridemic men compared with control subjects (P<.001). In the normotriglyceridemic group, CETP mass (P<.001) and activity (P<.005) were directly related to LPL activity After statistical adjustment for this close association, no significant relationship of CETP to HDL-C independent of LPL activity could be demonstrated in the normotriglyceridemic subjects. In contrast, CETP was unrelated to LPL activity in the hypertriglyceridemic subjects, but CETP concentrations showed a close inverse relationship to HDL-C (r=-.504, P=.014). Structural equation modeling of the association structures between HDL and fasting and postprandial triglycerides, endothelial lipases, and CETP in both groups indicated that the overall regression models for the two groups differed (P<.05). Specifically, the associations between CETP mass and activity and HDL-C differed between both groups (both P<.01). We conclude that high-normal CETP levels lower HDL-C in nonsmoking, nonobese men with moderate, primary hypertriglyceridemia on a hypolipidemic diet, but not in healthy, normotriglyceridemic men on an unrestricted diet. Thus, variation in CETP plasma concentrations may contribute to the high-triglyceride, low-HDL phenotype.

Key Words: triglycerides • HDL cholesterol • postprandial lipemia • lipoprotein lipase • cholesteryl ester transfer protein

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