Arteriosclerosis, Thrombosis, and Vascular Biology. 1996;16:1250-1255
© 1996 American Heart Association, Inc.
Articles |
Apolipoprotein E Alleles and Risk of Coronary Disease
A Meta-analysis
the Framingham Heart Study, National Heart, Lung, and Blood Institute (P.W.F.W.) and Boston University (M.G.L.), Framingham, and Tufts USDA Nutrition Center, Boston (E.J.S., J.M.O.), Mass.
Correspondence to Peter W.F. Wilson, MD, Framingham Heart Study, National Heart, Lung, and Blood Institute, 5 Thurber St, Framingham, MA 01701. E-mail peter@fram.nhlbi.nih.gov.
A meta-analysis was undertaken to assess the impact of apolipoprotein E (apo E) alleles (
2, 3, and 4) on coronary disease in 14 published observational studies (9 clinical coronary disease and 5 coronary angiography). In comparison with 3, the 4 allele was associated with greater odds for coronary heart disease, and summary estimates of the odds ratios (ORs) and (95% confidence intervals) for both sexes combined were OR=0.98 (0.85-1.14) for 2 and OR=1.26 (1.13-1.41) for 4. Separate analyses for men and women showed similar associations. In angiographic studies the relative odds for significant coronary artery disease among both sexes combined was OR=0.76 (0.55-1.05) for 2 and OR=1.11 (0.88-1.40) for 4. The overall impression is that 4 is associated with clinical and coronary disease and that results are similar in men and women.
Key Words: apolipoprotein E • coronary heart disease • meta-analysis • molecular epidemiology
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|
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|
|
|
|
 |
|
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|
|
|
|
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|
|
|
|
 |
|
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|
|
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|
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|
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
 |
|
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|
|
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|
|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
 S. J Lewis and E. J Brunner Methodological problems in genetic association studies of longevity--the apolipoprotein E gene as an example Int. J. Epidemiol., October 1, 2004; 33(5): 962 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 S. E. Humphries, P. M. Ridker, and P. J. Talmud Genetic Testing for Cardiovascular Disease Susceptibility: A Useful Clinical Management Tool or Possible Misinformation? Arterioscler Thromb Vasc Biol, April 1, 2004; 24(4): 628 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Novaro, R. Sachar, G. L. Pearce, D. L. Sprecher, and B. P. Griffin Association Between Apolipoprotein E Alleles and Calcific Valvular Heart Disease Circulation, October 14, 2003; 108(15): 1804 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Cooper Gene-Environment Interactions and the Etiology of Common Complex Disease Ann Intern Med, September 2, 2003; 139(5_Part_2): 437 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Infante-Rivard, E Levy, G-E Rivard, M Guiguet, and J-C Feoli-Fonseca Small babies receive the cardiovascular protective apolipoprotein {varepsilon}2 allele less frequently than expected J. Med. Genet., August 1, 2003; 40(8): 626 - 629. [Full Text]
|
|
|
|
 |
|
 A. F. Jorm, M. Prior, A. Sanson, D. Smart, Y. Zhang, and S. Easteal Apolipoprotein E Genotype and Temperament: A Longitudinal Study From Infancy to the Late Teens Psychosom Med, July 1, 2003; 65(4): 662 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Chen, S. E. Reis, C. Kammerer, W. Y. Craig, S. E. LaPierre, E. L. Zimmer, D. M. McNamara, D. F. Pauly, B. Sharaf, R. Holubkov, et al. Genetic Variation in Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 (LOX1) Gene and the Risk of Coronary Artery Disease Circulation, July 1, 2003; 107(25): 3146 - 3151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. S. Tan, S. Seshadri, A. Beiser, P. W. F. Wilson, D. P. Kiel, M. Tocco, R. B. D'Agostino, and P. A. Wolf Plasma Total Cholesterol Level as a Risk Factor for Alzheimer Disease: The Framingham Study Arch Intern Med, May 12, 2003; 163(9): 1053 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Anderson, J. F. Carlquist, B. D. Home, and J. B. Muhlestein Cardiovascular Pharmacogenomics: Current Status, Future Prospects Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2003; 8(1): 71 - 83. [Abstract] [PDF]
|
|
|
|
|
|
G. Davey Smith and S. Ebrahim 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int. J. Epidemiol., February 1, 2003; 32(1): 1 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kolovou, D. Daskalova, and D. P. Mikhailidis Apolipoprotein E Polymorphism and Atherosclerosis Angiology, January 1, 2003; 54(1): 59 - 71. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Jacobsen, J. Bentzen, M. Meldgaard, M. H. Jakobsen, M. Fenger, S. Kauppinen, and J. Skouv LNA-enhanced detection of single nucleotide polymorphisms in the apolipoprotein E Nucleic Acids Res., October 1, 2002; 30(19): e100 - e100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kivipelto, E.-L. Helkala, M. P. Laakso, T. Hanninen, M. Hallikainen, K. Alhainen, S. Iivonen, A. Mannermaa, J. Tuomilehto, A. Nissinen, et al. Apolipoprotein E {epsilon}4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease Ann Intern Med, August 6, 2002; 137(3): 149 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Keavney Genetic epidemiological studies of coronary heart disease Int. J. Epidemiol., August 1, 2002; 31(4): 730 - 736. [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Fillenbaum, D. G. Blazer, B. M. Burchett, A. M. Saunders, and D. H. Taylor Jr. Apolipoprotein E {varepsilon}4 and Risk of Mortality in African American and White Older Community Residents Gerontologist, June 1, 2002; 42(3): 381 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Djousse, R. H. Myers, M. A. Province, S. C. Hunt, J. H. Eckfeldt, G. Evans, J. M. Peacock, and R. C. Ellison Influence of Apolipoprotein E, Smoking, and Alcohol Intake on Carotid Atherosclerosis: National Heart, Lung, and Blood Institute Family Heart Study Stroke, May 1, 2002; 33(5): 1357 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Austin Ethical Issues in Human Genome Epidemiology: A Case Study Based on The Japanese American Family Study in Seattle, Washington Am. J. Epidemiol., April 1, 2002; 155(7): 585 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Dansky, P. Shu, M. Donavan, J. Montagno, D. L. Nagle, J. S. Smutko, N. Roy, S. Whiteing, J. Barrios, T. J. McBride, et al. A Phenotype-Sensitizing Apoe-Deficient Genetic Background Reveals Novel Atherosclerosis Predisposition Loci in the Mouse Genetics, April 1, 2002; 160(4): 1599 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. P. Agema, J. W. Jukema, S. N. Pimstone, and J. J. P. Kastelein Genetic aspects of restenosis after percutaneous coronary interventions;towards more tailored therapy Eur. Heart J., November 2, 2001; 22(22): 2058 - 2074. [PDF]
|
|
|
|
|
|
A.J.C. Slooter, M. L. Bots, L. M. Havekes, A. I. del Sol, M. Cruts, D. E. Grobbee, A. Hofman, C. Van Broeckhoven, J.C.M. Witteman, and C. M. van Duijn Apolipoprotein E and Carotid Artery Atherosclerosis: The Rotterdam Study Stroke, September 1, 2001; 32(9): 1947 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Berglund The APOE gene and diets--food (and drink) for thought Am. J. Clinical Nutrition, April 1, 2001; 73(4): 669 - 670. [Full Text] [PDF]
|
|
|
|
|
|
A. T Erkkila, E. S Sarkkinen, V. Lindi, S. Lehto, M. Laakso, and M. I. Uusitupa APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose Am. J. Clinical Nutrition, April 1, 2001; 73(4): 746 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Steed, R. Kong, J. Stygall, J. Acharya, M. Bolla, M. J.G. Harrison, S. E. Humphries, and S. P. Newman The role of apolipoprotein E in cognitive decline after cardiac operation Ann. Thorac. Surg., March 1, 2001; 71(3): 823 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Frikke-Schmidt, B.G. Nordestgaard, D. Thudium, M.-L. Moes Gronholdt, and A. Tybjarg-Hansen APOE genotype predicts AD and other dementia but not ischemic cerebrovascular disease Neurology, January 23, 2001; 56(2): 194 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.o. G. Nordestgaard, R. Frikke-Schmidt, and A. Tybjaerg-Hansen Mild hypercholesterolemia and premature heart disease: Reply J. Am. Coll. Cardiol., January 1, 2001; 37(1): 331 - 332. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hadjadj, Y. Gallois, G. Simard, B. Bouhanick, P. Passa, A. Grimaldi, P. Drouin, J. Tichet, and M. Marre Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein {varepsilon}, lipoprotein lipase and cholesteryl ester transfer protein Nephrol. Dial. Transplant., December 1, 2000; 15(12): 1971 - 1976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Batalla, R. Alvarez, J. R. Reguero, S. Hevia, G. Iglesias-Cubero, V. Alvarez, A. Cortina, P. Gonzalez, M. M. Celada, A. Medina, et al. Synergistic Effect between Apolipoprotein E and Angiotensinogen Gene Polymorphisms in the Risk for Early Myocardial Infarction Clin. Chem., December 1, 2000; 46(12): 1910 - 1915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Ballantyne, J. A. Herd, E. A. Stein, L. L. Ferlic, J. K. Dunn, A. M. Gotto Jr., and A. J. Marian Apolipoprotein E genotypes and response of plasma lipids and progression-regression of coronary atherosclerosis to lipid-lowering drug therapy J. Am. Coll. Cardiol., November 1, 2000; 36(5): 1572 - 1578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O. McCarron, K. W. Muir, J. A. R. Nicoll, J. Stewart, Y. Currie, K. Brown, and I. Bone Prospective Study of Apolipoprotein E Genotype and Functional Outcome Following Ischemic Stroke Arch Neurol, October 1, 2000; 57(10): 1480 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Isasi, S. Shea, R. J. Deckelbaum, S. C. Couch, T. J. Starc, J. D. Otvos, and L. Berglund Apolipoprotein epsilon 2 Allele Is Associated With an Anti-atherogenic Lipoprotein Profile in Children: The Columbia University BioMarkers Study Pediatrics, September 1, 2000; 106(3): 568 - 575. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
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|
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A. M. Dart and B. Cooper Independent Effects of Apo E Phenotype and Plasma Triglyceride on Lipoprotein Particle Sizes in the Fasting and Postprandial States Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2465 - 2473. [Abstract] [Full Text] [PDF]
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M. O. McCarron, D. Delong, and M. J. Alberts APOE genotype as a risk factor for ischemic cerebrovascular disease: A meta-analysis Neurology, October 1, 1999; 53(6): 1308 - 1308. [Abstract] [Full Text]
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E. Ilveskoski, M. Perola, T. Lehtimaki, P. Laippala, V. Savolainen, J. Pajarinen, A. Penttila, K. H. Lalu, A. Mannikko, K. K. Liesto, et al. Age-Dependent Association of Apolipoprotein E Genotype With Coronary and Aortic Atherosclerosis in Middle-Aged Men : An Autopsy Study Circulation, August 10, 1999; 100(6): 608 - 613. [Abstract] [Full Text] [PDF]
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S. N. Romas, M.-X. Tang, L. Berglund, and R. Mayeux APOE genotype, plasma lipids, lipoproteins, and AD in community elderly Neurology, August 1, 1999; 53(3): 517 - 517. [Abstract] [Full Text]
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C. Merchant, M.-X. Tang, S. Albert, J. Manly, Y. Stern, and R. Mayeux The influence of smoking on the risk of Alzheimer's disease Neurology, April 1, 1999; 52(7): 1408 - 1408. [Abstract] [Full Text] [PDF]
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 A. Inbal, D. Freimark, B. Modan, A. Chetrit, S. Matetzky, N. Rosenberg, R. Dardik, Z. Baron, and U. Seligsohn Synergistic Effects of Prothrombotic Polymorphisms and Atherogenic Factors on the Risk of Myocardial Infarction in Young Males Blood, April 1, 1999; 93(7): 2186 - 2190. [Abstract] [Full Text] [PDF]
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 C. D. S. Mamotte, M. Sturm, J. I. Foo, F. M. van Bockxmeer, and R. R. Taylor Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes Am J Physiol Endocrinol Metab, March 1, 1999; 276(3): E553 - E557. [Abstract] [Full Text] [PDF]
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M. Margaglione, D. Seripa, C. Gravina, E. Grandone, G. Vecchione, G. Cappucci, G. Merla, S. Papa, A. Postiglione, G. Di Minno, et al. Prevalence of Apolipoprotein E Alleles in Healthy Subjects and Survivors of Ischemic Stroke : An Italian Case-Control Study Stroke, February 1, 1998; 29(2): 399 - 403. [Abstract] [Full Text] [PDF]
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M. M. Zaman, S. Ikemoto, N. Yoshiike, C. Date, T. Yokoyama, and H. Tanaka Association of Apolipoprotein Genetic Polymorphisms With Plasma Cholesterol in a Japanese Rural Population : The Shibata Study Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3495 - 3504. [Abstract] [Full Text]
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A. Pablos-Mendez, R. Mayeux, C. Ngai, S. Shea, and L. Berglund Association of Apo E Polymorphism With Plasma Lipid Levels in a Multiethnic Elderly Population Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3534 - 3541. [Abstract] [Full Text]
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A. Zivelin, N. Rosenberg, H. Peretz, Y. Amit, N. Kornbrot, and U. Seligsohn Improved Method for Genotyping Apolipoprotein E Polymorphisms by a PCR-Based Assay Simultaneously Utilizing Two Distinct Restriction Enzymes Clin. Chem., September 1, 1997; 43(9): 1657 - 1659. [Full Text]
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