This Article Full Text Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Amundsen, T. Articles by Waage, A. Search for Related Content PubMed PubMed Citation Articles by Amundsen, T. Articles by Waage, A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB (L)-METHIONINE

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:1321-1323.)
© 1995 American Heart Association, Inc.

Articles

Plasma Homocysteine Levels in Patients With Deep Venous Thrombosis

Tore Amundsen; Per Magne Ueland; Anders Waage

From the University Hospital of Trondheim (T.A., A.W.), Norway, and Haukeland Hospital (P.M.U.), Bergen, Norway.

Correspondence to Tore Amundsen, Department of Medicine, Section of Haematology, University Hospital, N-7006 Trondheim, Norway.

Abstract Increased risk of arterial and venous thromboembolic disease is well documented in the homocystinuric patient. There is growing evidence that hyperhomocysteinemia is an independent risk factor for premature arteriosclerotic disease, including cerebral, peripheral, and coronary vascular diseases. So far no association has been established between hyperhomocysteinemia and venous thromboembolism.We studied 35 patients, young adults (age less than 56 years) with venographically and/or ultrasonographically verified deep venous thrombosis (DVT). Patients with coexisting diseases were excluded. Plasmahomocysteine levels before and after intake of methionine were measured 3 months or more after the time of diagnosis and compared with 39 control subjects. We found no significant difference in plasmahomocysteine levels between the young adults with deep venous thrombosis and control subjects. This indicates that hyperhomocysteinemia is not a frequent cause of DVT.

Key Words: thrombosis, deep venous • adults, young • plasmahomocysteine

This article has been cited by other articles:

				V. Ducros, C. Barro, J. Yver, G. Pernod, B. Polack, P. Carpentier, M.-D. Desruet, and J.-L. Bosson Should Plasma Homocysteine Be Used as a Biomarker of Venous Thromboembolism? A Case--Control Study Clinical and Applied Thrombosis/Hemostasis, October 1, 2009; 15(5): 517 - 522. [Abstract] [PDF]

				P. Lee and K. Prasad Hyperhomocysteinemia and Venous Thrombosis International Journal of Lower Extremity Wounds, March 1, 2002; 1(1): 4 - 12. [Abstract] [PDF]

				D. Gemmati, M. Previati, M. L. Serino, S. Moratelli, S. Guerra, S. Capitani, E. Forini, G. Ballerini, and G. L. Scapoli Low Folate Levels and Thermolabile Methylenetetrahydrofolate Reductase as Primary Determinant of Mild Hyperhomocystinemia in Normal and Thromboembolic Subjects Arterioscler Thromb Vasc Biol, July 1, 1999; 19(7): 1761 - 1767. [Abstract] [Full Text] [PDF]

				J. G. Ray Meta-analysis of Hyperhomocysteinemia as a Risk Factor for Venous Thromboembolic Disease Arch Intern Med, October 26, 1998; 158(19): 2101 - 2106. [Abstract] [Full Text] [PDF]

				L. A.J. Kluijtmans, G. H.J. Boers, B. Verbruggen, F. J.M. Trijbels, I. R.O. Novakova, and H. J. Blom Homozygous Cystathionine beta -Synthase Deficiency, Combined With Factor V Leiden or Thermolabile Methylenetetrahydrofolate Reductase in the Risk of Venous Thrombosis Blood, March 15, 1998; 91(6): 2015 - 2018. [Abstract] [Full Text] [PDF]

				M. Cattaneo, M. L. Monzani, I. Martinelli, C. R. Falcon, P. M. Mannucci, and P. M. Ridker Interrelation of Hyperhomocyst(e)inemia, Factor V Leiden, and Risk of Future Venous Thromboembolism • Response Circulation, January 27, 1998; 97(3): 295 - 296. [Full Text]

				M. H. Moghadasian, B. M. McManus, and J. J. Frohlich Homocyst(e)ine and Coronary Artery Disease: Clinical Evidence and Genetic and Metabolic Background Arch Intern Med, November 10, 1997; 157(20): 2299 - 2308. [Abstract] [PDF]

				C. Legnani, G. Palareti, F. Grauso, S. Sassi, G. Grossi, S. Piazzi, F. Bernardi, G. Marchetti, P. Ferraresi, and S. Coccheri Hyperhomocyst(e)inemia and a Common Methylenetetrahydrofolate Reductase Mutation (Ala223Val MTHFR) in Patients With Inherited Thrombophilic Coagulation Defects Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2924 - 2929. [Abstract] [Full Text]

				K. Kottke-Marchant, R. Green, D. W. Jacobsen, A. Gupta, S. R. Savon, M. Secic, and K. Robinson High Plasma Homocysteine: A Risk Factor for Arterial and Venous Thrombosis in Patients with Normal Coagulation Profiles Clinical and Applied Thrombosis/Hemostasis, October 1, 1997; 3(4): 239 - 244. [Abstract] [PDF]

				A. D'Angelo and J. Selhub Homocysteine and Thrombotic Disease Blood, July 1, 1997; 90(1): 1 - 11. [Full Text] [PDF]

				M. D. Phillips Interrelated Risk Factors for Venous Thromboembolism Circulation, April 1, 1997; 95(7): 1749 - 1751. [Full Text]

				P. M. Ridker, C. H. Hennekens, J. Selhub, J. P. Miletich, M. R. Malinow, and M. J. Stampfer Interrelation of Hyperhomocyst(e)inemia, Factor V Leiden, and Risk of Future Venous Thromboembolism Circulation, April 1, 1997; 95(7): 1777 - 1782. [Abstract] [Full Text]