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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:918-923.)
© 1995 American Heart Association, Inc.

Articles

Inhibition of Atherosclerosis and Myocardial Lesions in the JCR:LA-cp Rat by ß,ß'-Tetramethylhexadecanedioic Acid (MEDICA 16)

James C. Russell; Roger M. Amy; Sandra E. Graham; Peter J. Dolphin; George O. Wood; Jacob Bar-Tana

From the Departments of Surgery (J.C.R., S.E.G.) and Pathology (G.O.W.), University of Alberta, Edmonton; British Columbia Cancer Agency (R.M.A.), Vancouver; Department of Biochemistry (P.J.D.), Dalhousie University, Halifax, Nova Scotia, Canada; and Department of Human Nutrition and Metabolism (J.B.-T.), Hadassah Medical School, Hebrew University, Jerusalem, Israel.

Correspondence to Dr J.C. Russell, Department of Surgery, 275 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.

Abstract Atherosclerosis-prone, insulin-resistant JCR:LA-cp male rats were treated from 6 weeks to 39 weeks of age with ß,ß'-tetramethylhexadecanedioic acid (MEDICA 16). Body weights were reduced (13%, P<.001) at 36 weeks without any accompanying decrease in food consumption. The treatment did not cause any significant change in plasma glucose or fasting insulin concentrations. There was a significant decrease in the extreme hyperplasia of the islets of Langerhans (38%, P<.05). The marked VLDL hypertriglyceridemia was decreased by 70% (P<.001), with an accompanying significant reduction in cholesterol concentrations. The severity of raised atherosclerotic lesions on the aortic arch was very markedly reduced (P<.01) in treated rats. This was accompanied by a reduction (P<.01) in the incidence of ischemic myocardial lesions. We conclude that long-term (33 weeks) MEDICA 16 treatment of an animal model for the obesity/insulin-resistant/hyperlipidemic syndrome not only markedly improved lipid metabolism, but also inhibited the development of advanced cardiovascular disease.

Key Words: MEDICA 16 • myocardial lesions • hypertriglyceridemia • JCR:LA-cp rat • atherosclerosis

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