© 1995 American Heart Association, Inc.
Articles |
No Association Between Plasma Lipoprotein(a) Concentrations and the Presence or Absence of Coronary Atherosclerosis in African-Americans
From the Department of Cardiology, the Cleveland Clinic Foundation, Cleveland, Ohio (D.J.M.), the Departments of Internal Medicine and Molecular Genetics, University of Texas Southwestern Medical Center, and the Center for Demographics and Population Genetics, University of Texas Health Science Center (E.B.), Houston, Tex.
Correspondence to Dr Helen H. Hobbs, Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235-9046.
Abstract Elevated plasma concentrations of lipoprotein(a) [Lp(a)] are associated with coronary atherosclerosis in Caucasians. Although African-Americans have a higher median plasma Lp(a) concentration than Caucasians, they do not have a greater incidence of coronary atherosclerosis. This study was performed to determine whether the plasma concentration of Lp(a) is associated with coronary atherosclerosis in African-Americans. The fasting plasma concentrations of Lp(a) and lipoproteins were measured in 140 African-American subjects (62 men, 78 women, aged 31 to 80 years) 18±16 months (mean±SD) after they underwent coronary angiography: 72 had angiographically normal coronary arteries and 68 had >70% luminal diameter narrowing of one or more major epicardial coronary arteries. The groups were similar in age, sex, and other risk factors for atherosclerosis. The subjects with coronary artery disease had higher plasma concentrations of total cholesterol, triglycerides, and VLDL and LDL cholesterol (P=.04) and lower concentrations of HDL cholesterol (P=.0001) than subjects without coronary artery disease, but there was no significant difference in the plasma concentration of Lp(a). The distribution of apolipoprotein(a) alleles by size was also not significantly different between the two groups. These results suggest that the plasma concentration of Lp(a) is not an independent risk factor for coronary artery disease in African-Americans.
Key Words: lipoprotein(a) • African-Americans • plasminogen
This article has been cited by other articles:
 |
|
 |
|
  F. J Khawaja and I. J Kullo Novel markers of peripheral arterial disease Vascular Medicine, November 1, 2009; 14(4): 381 - 392. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Tsimikas, P. Clopton, E. S. Brilakis, S. M. Marcovina, A. Khera, E. R. Miller, J. A. de Lemos, and J. L. Witztum Relationship of Oxidized Phospholipids on Apolipoprotein B-100 Particles to Race/Ethnicity, Apolipoprotein(a) Isoform Size, and Cardiovascular Risk Factors: Results From the Dallas Heart Study Circulation, April 7, 2009; 119(13): 1711 - 1719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Lanktree, C. Rajakumar, J. H. Brunt, M. L. Koschinsky, P. W. Connelly, and R. A. Hegele Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR J. Lipid Res., April 1, 2009; 50(4): 768 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Volcik, R. A. Barkley, R. G. Hutchinson, T. H. Mosley, G. Heiss, A. R. Sharrett, C. M. Ballantyne, and E. Boerwinkle Apolipoprotein E Polymorphisms Predict Low Density Lipoprotein Cholesterol Levels and Carotid Artery Wall Thickness but Not Incident Coronary Heart Disease in 12,491 ARIC Study Participants Am. J. Epidemiol., August 15, 2006; 164(4): 342 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Guerra, Z. Yu, S. Marcovina, R. Peshock, J. C. Cohen, and H. H. Hobbs Lipoprotein(a) and Apolipoprotein(a) Isoforms: No Association With Coronary Artery Calcification in The Dallas Heart Study Circulation, March 29, 2005; 111(12): 1471 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. Kullo and C. M. Ballantyne Conditional Risk Factors for Atherosclerosis Mayo Clin. Proc., February 1, 2005; 80(2): 219 - 230. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Berglund and R. Ramakrishnan Lipoprotein(a): An Elusive Cardiovascular Risk Factor Arterioscler Thromb Vasc Biol, December 1, 2004; 24(12): 2219 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. Kullo, K. R. Bailey, L. F. Bielak, P. F. Sheedy II, G. G. Klee, S. L. Kardia, P. A. Peyser, E. Boerwinkle, and S. T. Turner Lack of Association Between Lipoprotein(a) and Coronary Artery Calcification in the Genetic Epidemiology Network of Arteriopathy (GENOA) Study Mayo Clin. Proc., October 1, 2004; 79(10): 1258 - 1263. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Albert, J. Torres, R. J. Glynn, and P. M Ridker Perspective on Selected Issues in Cardiovascular Disease Research With a Focus on Black Americans Circulation, July 13, 2004; 110(2): e7 - e12. [Full Text] [PDF]
|
|
|
|
|
|
References Circulation, December 17, 2002; 106(25): 3373 - 3421. [Full Text]
|
|
|
|
|
|
F. Paultre, C. H. Tuck, B. Boden-Albala, D. E. Kargman, E. Todd, J. Jones, M. C. Paik, R. L. Sacco, and L. Berglund Relation of Apo(a) Size to Carotid Atherosclerosis in an Elderly Multiethnic Population Arterioscler Thromb Vasc Biol, January 1, 2002; 22(1): 141 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rubin, T. A. Pearson, R. G. Reed, and L. Berglund Fluorescence-based, Nonradioactive Method for Efficient Detection of the Pentanucleotide Repeat (TTTTA)n Polymorphism in the Apolipoprotein(a) Gene Clin. Chem., October 1, 2001; 47(10): 1758 - 1762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Paultre, T. A. Pearson, H. F. C. Weil, C. H. Tuck, M. Myerson, J. Rubin, C. K. Francis, H. F. Marx, E. F. Philbin, R. G. Reed, et al. High Levels of Lp(a) With a Small Apo(a) Isoform Are Associated With Coronary Artery Disease in African American and White Men Arterioscler Thromb Vasc Biol, December 1, 2000; 20(12): 2619 - 2624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Grundy, R. Pasternak, P. Greenland, S. Smith Jr, and V. Fuster Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: A statement for healthcare professionals from the American Heart Association and the American College of Cardiology J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1348 - 1359. [Full Text] [PDF]
|
|
|
|
|
|
S. M. Grundy, R. Pasternak, P. Greenland, S. Smith Jr, and V. Fuster Assessment of Cardiovascular Risk by Use of Multiple-Risk-Factor Assessment Equations : A Statement for Healthcare Professionals From the American Heart Association and the American College of Cardiology Circulation, September 28, 1999; 100(13): 1481 - 1492. [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Harjai Potential New Cardiovascular Risk Factors: Left Ventricular Hypertrophy, Homocysteine, Lipoprotein(a), Triglycerides, Oxidative Stress, and Fibrinogen Ann Intern Med, September 7, 1999; 131(5): 376 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fontana, V. Mooser, P. Bovet, C. Shamlaye, B. Burnand, V. Lenain, S. M. Marcovina, W. Riesen, and R. Darioli Dose-Dependent Inverse Relationship Between Alcohol Consumption and Serum Lp(a) Levels in Black African Males Arterioscler Thromb Vasc Biol, April 1, 1999; 19(4): 1075 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Grundy, G. J. Balady, M. H. Criqui, G. Fletcher, P. Greenland, L. F. Hiratzka, N. Houston-Miller, P. Kris-Etherton, H. M. Krumholz, J. LaRosa, et al. Primary Prevention of Coronary Heart Disease: Guidance From Framingham : A Statement for Healthcare Professionals From the AHA Task Force on Risk Reduction Circulation, May 19, 1998; 97(18): 1876 - 1887. [Full Text] [PDF]
|
|
|
|
|
|
P. N. Hopkins, L. L. Wu, S. C. Hunt, B. C. James, G. M. Vincent, and R. R. Williams Lipoprotein(a) Interactions With Lipid and Nonlipid Risk Factors in Early Familial Coronary Artery Disease Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2783 - 2792. [Abstract] [Full Text]
|
|
|
|
|
|
R. A. Hegele, W. C. Breckenridge, J. H. Brunt, and P. W. Connelly Genetic Variation in Factor VII Associated with Variation in Plasma Lipoprotein(a) Concentration Arterioscler Thromb Vasc Biol, September 1, 1997; 17(9): 1701 - 1706. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. W. F. Wilson and W. B. Kannel Should We Measure Lipoprotein Lp(a)? Arch Intern Med, June 9, 1997; 157(11): 1161 - 1162. [Abstract] [PDF]
|
|