Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:783-785
© 1995 American Heart Association, Inc.
Articles |
Factor V Leiden Gene Mutation and Thrombin Generation in Relation to the Development of Acute Stroke
From the Diabetes and Thrombosis Research Group (A. Catto, A. Carter, J.B., P.J.G.), Division of Medicine, School of Medicine, University of Leeds, Leeds General Infirmary, Leeds, and the Department of Haematology (H.I., T.A.B., H.P., D.A.L.), Charing Cross and Westminster Medical School, London, UK.
Correspondence to Dr A. Catto, Diabetes and Thrombosis Research Group, Division of Medicine, School of Medicine, University of Leeds, Leeds General Infirmary, Leeds LS1 3EX, UK.
Abstract To determine the prevalence of the factor V Leiden gene mutation in relation to the phenotypes of cerebral infarction and cerebral hemorrhage, we studied 386 randomly selected cases of acute stroke and 247 control subjects. Factor V genotype was determined by amplification of a 267-bp sequence of exon/intron 10 of the factor V gene. Levels of prothrombin fragment F1+2, a marker of thrombin generation, were determined in both acute and convalescent stroke and related to factor V genotype. Prothrombin fragment F1+2 was assessed by using an enzyme-linked immunosorbent assay. Sixteen stroke cases (4.1%) were identified as having the mutation compared with 14 (5.6%) control subjects. Prothrombin fragment F1+2 levels were estimated in 191 cases and found to be elevated both acutely and after 3 months, but they were not related to factor V genotype. Prothrombin fragment F1+2 is elevated in acute stroke and requires further evaluation in relation to cerebrovascular disease. These results suggest that the factor V Leiden gene mutation is not a risk factor for arterial thrombosis causing stroke.
Key Words: factor V mutation • prothrombin F1+2 • stroke
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