Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:1987-1994
© 1995 American Heart Association, Inc.
Articles |
High-Density Lipoproteins Inhibit Cytokine-Induced Expression of Endothelial Cell Adhesion Molecules
From the Hanson Center for Cancer Research, Department of Human Immunology, Department of Lipid Research (G.W.C., J.R.G., M.A.V.), the Cardiovascular Investigation Unit, Royal Adelaide Hospital (K.-A.R.), and the University of Adelaide, Department of Medicine, Royal Adelaide Hospital (P.J.B.), Adelaide, Australia.
Correspondence to Gillian Cockerill, Hanson Center for Cancer Research, Department of Human Immunology, IMVS, PO Box 14, Rundle Mall, Adelaide 5000, South Australia. E-mail gcockeri@immuno.imvs.sa.gov.au.
Abstract While an elevated plasma concentration of HDLs is
protective against the development of atherosclerosis
and ensuing coronary heart disease (CHD), the mechanism of this
protection is unknown. One early cellular event in atherogenesis is the
adhesion of mononuclear leukocytes to the endothelium.
This event is mediated principally by vascular cell adhesion molecule-1
(VCAM-1) but also involves other molecules, such as intercellular
adhesion molecule-1 (ICAM-1) and E-selectin. We have investigated the
effect of isolated plasma HDLs and reconstituted HDLs on the expression
of these molecules by endothelial cells. We show that
physiological concentrations of HDLs inhibit tumor
necrosis factor-
(TNF-) or interleukin-1 (IL-1) induction of
these leukocyte adhesion molecules in a concentration-dependent
manner. Steady state mRNA levels of TNF-–induced VCAM-1 and
E-selectin are significantly reduced by
physiological concentrations of HDLs. At an HDL
concentration of 1 mg/mL apolipoprotein A-I, the protein expressions of
VCAM-1, ICAM-1, and E-selectin were inhibited by 89.6±0.4% (mean±SD,
n=4), 64.8±1.0%, and 79.2±0.4%, respectively. In contrast, HDLs
have no effect on the expression of platelet
endothelial cell adhesion molecule (PECAM) or on the
expression of the p55 and p75 subunits of the TNF- receptor. HDLs
were effective when added from 16 hours before to 5 minutes after
cytokine stimulation. HDLs had no effect on
TNF-–induced expression of ICAM-1 by human foreskin
fibroblasts, suggesting that the effect is cell-type restricted.
This study provides the first evidence that HDLs may protect
against CHD by inhibiting the expression of adhesion molecules,
which are required for the interaction between leukocytes and the
endothelium.
Key Words: inflammation • coronary heart disease • VCAM-1 • E-selectin
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B. J. O'Connell and J. Genest Jr High-Density Lipoproteins and Endothelial Function Circulation, October 16, 2001; 104(16): 1978 - 1983. [Abstract] [Full Text] [PDF]
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G. W. COCKERILL, M. C. MCDONALD, H. MOTA-FILIPE, S. CUZZOCREA, N. E. MILLER, and C. THIEMERMANN High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock FASEB J, September 1, 2001; 15(11): 1941 - 1952. [Abstract] [Full Text] [PDF]
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G. W. Cockerill, T. Y. Huehns, A. Weerasinghe, C. Stocker, P. G. Lerch, N. E. Miller, and D. O. Haskard Elevation of Plasma High-Density Lipoprotein Concentration Reduces Interleukin-1-Induced Expression of E-Selectin in an In Vivo Model of Acute Inflammation Circulation, January 2, 2001; 103(1): 108 - 112. [Abstract] [Full Text] [PDF]
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D. Sviridov, L. E. Pyle, M. Jauhiainen, C. Ehnholm, and N. H. Fidge Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of pre{beta}-high density lipoprotein to {alpha}-high density lipoprotein J. Lipid Res., November 1, 2000; 41(11): 1872 - 1882. [Abstract] [Full Text]
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G. THEILMEIER, B. DE GEEST, P. P. VAN VELDHOVEN, D. STENGEL, C. MICHIELS, M. LOX, M. LANDELOOS, M. J. CHAPMAN, E. NINIO, D. COLLEN, et al. HDL-associated PAF-AH reduces endothelial adhesiveness in apoE-/- mice FASEB J, October 1, 2000; 14(13): 2032 - 2039. [Abstract] [Full Text]
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P. W. Baker, K.-A. Rye, J. R. Gamble, M. A. Vadas, and P. J. Barter Phospholipid composition of reconstituted high density lipoproteins influences their ability to inhibit endothelial cell adhesion molecule expression J. Lipid Res., August 1, 2000; 41(8): 1261 - 1267. [Abstract] [Full Text]
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K. J. Williams, R. Scalia, K. D. Mazany, W. V. Rodrigueza, and A. M. Lefer Rapid Restoration of Normal Endothelial Functions in Genetically Hyperlipidemic Mice by a Synthetic Mediator of Reverse Lipid Transport Arterioscler Thromb Vasc Biol, April 1, 2000; 20(4): 1033 - 1039. [Abstract] [Full Text] [PDF]
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B. Foger, M. Chase, M. J. Amar, B. L. Vaisman, R. D. Shamburek, B. Paigen, J. Fruchart-Najib, J. A. Paiz, C. A. Koch, R. F. Hoyt, et al. Cholesteryl Ester Transfer Protein Corrects Dysfunctional High Density Lipoproteins and Reduces Aortic Atherosclerosis in Lecithin Cholesterol Acyltransferase Transgenic Mice J. Biol. Chem., December 24, 1999; 274(52): 36912 - 36920. [Abstract] [Full Text] [PDF]
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P. Xia, M. A. Vadas, K.-A. Rye, P. J. Barter, and J. R. Gamble High Density Lipoproteins (HDL) Interrupt the Sphingosine Kinase Signaling Pathway. A POSSIBLE MECHANISM FOR PROTECTION AGAINST ATHEROSCLEROSIS BY HDL J. Biol. Chem., November 12, 1999; 274(46): 33143 - 33147. [Abstract] [Full Text] [PDF]
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K. K. Koh, A. Blum, L. Hathaway, R. Mincemoyer, G. Csako, M. A. Waclawiw, J. A. Panza, and R. O. Cannon III Vascular Effects of Estrogen and Vitamin E Therapies in Postmenopausal Women Circulation, November 2, 1999; 100(18): 1851 - 1857. [Abstract] [Full Text] [PDF]
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K. Saku, B. Zhang, K. Shirai, S. Jimi, K. Yoshinaga, and K. Arakawa Hyperinsulinemic hypoalphalipoproteinemia as a new indicator for coronary heart disease J. Am. Coll. Cardiol., November 1, 1999; 34(5): 1443 - 1451. [Abstract] [Full Text] [PDF]
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R. K. Tangirala, K. Tsukamoto, S. H. Chun, D. Usher, E. Pure, and D. J. Rader Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of Apolipoprotein A-I in Mice Circulation, October 26, 1999; 100(17): 1816 - 1822. [Abstract] [Full Text] [PDF]
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L. Lindstedt, J. Saarinen, N. Kalkkinen, H. Welgus, and P. T. Kovanen Matrix Metalloproteinases-3, -7, and -12, but Not -9, Reduce High Density Lipoprotein-induced Cholesterol Efflux from Human Macrophage Foam Cells by Truncation of the Carboxyl Terminus of Apolipoprotein A-I. PARALLEL LOSSES OF PRE-beta PARTICLES AND THE HIGH AFFINITY COMPONENT OF EFFLUX J. Biol. Chem., August 6, 1999; 274(32): 22627 - 22634. [Abstract] [Full Text] [PDF]
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H. M. Dansky, S. A. Charlton, J. L. Sikes, S. C. Heath, R. Simantov, L. F. Levin, P. Shu, K. J. Moore, J. L. Breslow, and J. D. Smith Genetic Background Determines the Extent of Atherosclerosis in ApoE-Deficient Mice Arterioscler Thromb Vasc Biol, August 1, 1999; 19(8): 1960 - 1968. [Abstract] [Full Text] [PDF]
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L. E. P. Rohde, C. H. Hennekens, and P. M. Ridker Cross-Sectional Study of Soluble Intercellular Adhesion Molecule-1 and Cardiovascular Risk Factors in Apparently Healthy Men Arterioscler Thromb Vasc Biol, July 1, 1999; 19(7): 1595 - 1599. [Abstract] [Full Text] [PDF]
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J. A. McCrohon, W. Jessup, D. J. Handelsman, and D. S. Celermajer Androgen Exposure Increases Human Monocyte Adhesion to Vascular Endothelium and Endothelial Cell Expression of Vascular Cell Adhesion Molecule-1 Circulation, May 4, 1999; 99(17): 2317 - 2322. [Abstract] [Full Text] [PDF]
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G. W. Cockerill, J. Saklatvala, S. H. Ridley, H. Yarwood, N. E. Miller, B. Oral, S. Nithyanathan, G. Taylor, and D. O. Haskard High-Density Lipoproteins Differentially Modulate Cytokine-Induced Expression of E-Selectin and Cyclooxygenase-2 Arterioscler Thromb Vasc Biol, April 1, 1999; 19(4): 910 - 917. [Abstract] [Full Text] [PDF]
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N. H. Fidge High density lipoprotein receptors, binding proteins, and ligands J. Lipid Res., February 1, 1999; 40(2): 187 - 201. [Abstract] [Full Text]
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P. W. Baker, K.-A. Rye, J. R. Gamble, M. A. Vadas, and P. J. Barter Ability of reconstituted high density lipoproteins to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells J. Lipid Res., February 1, 1999; 40(2): 345 - 353. [Abstract] [Full Text]
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K. Saku, B. Zhang, T. Ohta, and K. Arakawa Quantity and function of high density lipoprotein as an indicator of coronary atherosclerosis J. Am. Coll. Cardiol., February 1, 1999; 33(2): 436 - 443. [Abstract] [Full Text] [PDF]
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K. K. Koh, C. Cardillo, M. N. Bui, L. Hathaway, G. Csako, M. A. Waclawiw, J. A. Panza, and R. O. Cannon III Vascular Effects of Estrogen and Cholesterol-Lowering Therapies in Hypercholesterolemic Postmenopausal Women Circulation, January 26, 1999; 99(3): 354 - 360. [Abstract] [Full Text] [PDF]
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P. Benoit, F. Emmanuel, J. M. Caillaud, L. Bassinet, G. Castro, P. Gallix, J. C. Fruchart, D. Branellec, P. Denefle, and N. Duverger Somatic Gene Transfer of Human ApoA-I Inhibits Atherosclerosis Progression in Mouse Models Circulation, January 12, 1999; 99(1): 105 - 110. [Abstract] [Full Text] [PDF]
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L. E. Rohde, R. T. Lee, J. Rivero, M. Jamacochian, L. H. Arroyo, W. Briggs, N. Rifai, P. Libby, M. A. Creager, and P. M. Ridker Circulating Cell Adhesion Molecules Are Correlated With Ultrasound-Based Assessment of Carotid Atherosclerosis Arterioscler Thromb Vasc Biol, November 1, 1998; 18(11): 1765 - 1770. [Abstract] [Full Text] [PDF]
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D. T. Ashby, K.-A. Rye, M. A. Clay, M. A. Vadas, J. R. Gamble, and P. J. Barter Factors Influencing the Ability of HDL to Inhibit Expression of Vascular Cell Adhesion Molecule-1 in Endothelial Cells Arterioscler Thromb Vasc Biol, September 1, 1998; 18(9): 1450 - 1455. [Abstract] [Full Text] [PDF]
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Y. Abe, B. El-Masri, K. T. Kimball, H. Pownall, C. F. Reilly, K. Osmundsen, C. W. Smith, and C. M. Ballantyne Soluble Cell Adhesion Molecules in Hypertriglyceridemia and Potential Significance on Monocyte Adhesion Arterioscler Thromb Vasc Biol, May 1, 1998; 18(5): 723 - 731. [Abstract] [Full Text] [PDF]
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R. Batal, M. Tremblay, L. Krimbou, O. Mamer, J. Davignon, J. Genest Jr, and J. S. Cohn Familial HDL Deficiency Characterized by Hypercatabolism of Mature ApoA-I but Not ProApoA-I Arterioscler Thromb Vasc Biol, April 1, 1998; 18(4): 655 - 664. [Abstract] [Full Text] [PDF]
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S.-J. Hwang, C. M. Ballantyne, A. R. Sharrett, L. C. Smith, C. E. Davis, A. M. Gotto Jr, and E. Boerwinkle Circulating Adhesion Molecules VCAM-1, ICAM-1, and E-selectin in Carotid Atherosclerosis and Incident Coronary Heart Disease Cases : The Atherosclerosis Risk In Communities (ARIC) Study Circulation, December 16, 1997; 96(12): 4219 - 4225. [Abstract] [Full Text]
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A. Matsumoto, A. Mitchell, H. Kurata, L. Pyle, K. Kondo, H. Itakura, and N. Fidge Cloning and Characterization of HB2, a Candidate High Density Lipoprotein Receptor. SEQUENCE HOMOLOGY WITH MEMBERS OF THE IMMUNOGLOBULIN SUPERFAMILY OF MEMBRANE PROTEINS J. Biol. Chem., July 4, 1997; 272(27): 16778 - 16782. [Abstract] [Full Text] [PDF]
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