Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:1882-1888
© 1995 American Heart Association, Inc.
Articles |
Intravenous Injection of Rabbit Apolipoprotein A-I Inhibits the Progression of Atherosclerosis in Cholesterol-Fed Rabbits
From the Department of Biochemistry (A.M., M.S., H.H., Y.-I.S., S.H.), the Second Department of Pathology (M.N., Y.R., K.T.), and the Department of Pediatrics (T.O.), Kumamoto University School of Medicine, and the Chemo-Sero-Therapeutic Research Institute (S.S., W.M., T. Takiue, F.M., T. Terano), Kumamoto, Japan.
Correspondence to Seikoh Horiuchi, MD, PhD, Department of Biochemistry, Kumamoto University School of Medicine, Honjo 2-2-1, Kumamoto 860, Japan.
Abstract The effects of intravenous injection of purified rabbit apoA-I on the progression of aortic atherosclerosis in cholesterol-fed rabbits were examined. In experiment 1, 28 rabbits were equally divided into groups A and B and fed a 0.5% cholesterol diet for 90 days. For the last 30 days, group B received 40 mg apoA-I every week. The fatty streak lesions in group B (23.9±15.6%) were significantly suppressed compared with those in group A (46.0±24.9%) (P<.05). In experiment 2, 33 rabbits were divided into four groups (8 or 9 rabbits per group) and fed a 0.5% cholesterol diet. Group A was killed on day 105, while groups B, C, and D were maintained for an additional 60 days on a normal diet, during which time groups C and D received 1 mg apoA-I every other day or 40 mg apoA-I every week, respectively. The lesions in group C (70.2±15.4%) and group D (65.7±20.0%) were significantly suppressed compared with those in group B (86.2±13.7%) (P<.05) but were not reduced to the level of group A (50.0±22.9%). Although apparent regression was not observed under these conditions, the present study provided the first evidence for the antiatherogenic effect of homologous apoA-I on the progression of atherosclerosis in cholesterol-fed rabbits.
Key Words: apoA-I • HDL • diet-induced atherosclerosis • cholesterol-fed rabbits • experimental atherosclerosis
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