Arteriosclerosis and Thrombosis, Vol 14, 1098-1104, Copyright © 1994 by American Heart Association

ARTICLES

Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study

AR Sharrett, W Patsch, PD Sorlie, G Heiss, MG Bond and CE Davis
Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Previous research shows generally greater proportional elevation in apolipoprotein B (apoB) levels than in low-density lipoprotein cholesterol (LDL-C) in coronary heart disease (CHD) case subjects compared with control subjects. The Atherosclerosis Risk in Communities study provided general populations of 7261 men and women free of cardiovascular symptoms for evaluating the associations between intima- media thickening in extracranial carotid arteries measured using ultrasound imaging and fasting plasma LDL-C, high-density lipoprotein cholesterol (HDL-C), apoB, apolipoprotein A-I (apoA-I), triglycerides, and HDL density subfractions. A CHD group was selected for comparison. Lipid factors show approximately linear associations with carotid thickness: positive for LDL-C and plasma apoB and negative for HDL-C and apoA-I levels. Apolipoproteins and HDL density subfractions did not contribute to the association after accounting for LDL-C and HDL-C. Compared with control subjects, persons whose carotid thickness exceeded 0.9 mm had greater proportional elevations in LDL-C than in apoB, whereas HDL-C reductions were small. CHD case subjects showed greater proportional elevations of apoB than LDL-C. Although the lipid profiles associated with asymptomatic carotid wall thickening and stenotic coronary disease are similar, the differences found suggest that LDL-C is the most important lipid factor in earlier stages of atherogenesis, whereas the metabolism of triglyceride-rich lipoproteins and its effects on LDL and HDL may be more relevant to later atherothrombotic processes.

This article has been cited by other articles:

				G. Liew, A. R. Sharrett, J. J. Wang, R. Klein, B. E. K. Klein, P. Mitchell, and T. Y. Wong Relative Importance of Systemic Determinants of Retinal Arteriolar and Venular Caliber: The Atherosclerosis Risk in Communities Study Arch Ophthalmol, October 1, 2008; 126(10): 1404 - 1410. [Abstract] [Full Text] [PDF]

				C. Reitz, M.-X. Tang, J. Luchsinger, and R. Mayeux Relation of Plasma Lipids to Alzheimer Disease and Vascular Dementia Arch Neurol, May 1, 2004; 61(5): 705 - 714. [Abstract] [Full Text] [PDF]

				E. Shahar, L. E. Chambless, W. D. Rosamond, L. L. Boland, C. M. Ballantyne, P. G. McGovern, and A. R. Sharrett Plasma Lipid Profile and Incident Ischemic Stroke: The Atherosclerosis Risk in Communities (ARIC) Study Stroke, March 1, 2003; 34(3): 623 - 631. [Abstract] [Full Text] [PDF]

				H. N. Ginsberg New Perspectives on Atherogenesis: Role of Abnormal Triglyceride-Rich Lipoprotein Metabolism Circulation, October 15, 2002; 106(16): 2137 - 2142. [Full Text] [PDF]

				L. E. Chambless, A. R. Folsom, V. Davis, R. Sharrett, G. Heiss, P. Sorlie, M. Szklo, G. Howard, and G. W. Evans Risk Factors for Progression of Common Carotid Atherosclerosis: The Atherosclerosis Risk in Communities Study, 1987-1998 Am. J. Epidemiol., January 1, 2002; 155(1): 38 - 47. [Abstract] [Full Text] [PDF]

				P. K. Shah, S. Kaul, J. Nilsson, and B. Cercek Exploiting the Vascular Protective Effects of High-Density Lipoprotein and Its Apolipoproteins: An Idea Whose Time for Testing Is Coming, Part I Circulation, November 6, 2001; 104(19): 2376 - 2383. [Full Text] [PDF]

				J. D. Beck, J. R. Elter, G. Heiss, D. Couper, S. M. Mauriello, and S. Offenbacher Relationship of Periodontal Disease to Carotid Artery Intima-Media Wall Thickness: The Atherosclerosis Risk in Communities (ARIC) Study Arterioscler Thromb Vasc Biol, November 1, 2001; 21(11): 1816 - 1822. [Abstract] [Full Text] [PDF]

				A. R. Sharrett, C. M. Ballantyne, S. A. Coady, G. Heiss, P. D. Sorlie, D. Catellier, and W. Patsch Coronary Heart Disease Prediction From Lipoprotein Cholesterol Levels, Triglycerides, Lipoprotein(a), Apolipoproteins A-I and B, and HDL Density Subfractions: The Atherosclerosis Risk in Communities (ARIC) Study Circulation, September 4, 2001; 104(10): 1108 - 1113. [Abstract] [Full Text] [PDF]

				T. Mannami, S. Baba, and J. Ogata Potential of Carotid Enlargement as a Useful Indicator Affected by High Blood Pressure in a Large General Population of a Japanese City : The Suita Study Stroke, December 1, 2000; 31(12): 2958 - 2965. [Abstract] [Full Text] [PDF]

				H. D. White, R. J. Simes, N. E. Anderson, G. J. Hankey, J. D.G. Watson, D. Hunt, D. M. Colquhoun, P. Glasziou, S. MacMahon, A. C. Kirby, et al. Pravastatin Therapy and the Risk of Stroke N. Engl. J. Med., August 3, 2000; 343(5): 317 - 326. [Abstract] [Full Text] [PDF]

				D. Pratico, Y. Cheng, and G. A. FitzGerald TP or Not TP: Primary Mediators in a Close Runoff? Arterioscler Thromb Vasc Biol, July 1, 2000; 20(7): 1695 - 1698. [Full Text] [PDF]

				R. Klein, A. R. Sharrett, B. E. K. Klein, L. E. Chambless, L. S. Cooper, L. D. Hubbard, and G. Evans Are Retinal Arteriolar Abnormalities Related to Atherosclerosis? : The Atherosclerosis Risk in Communities Study Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1644 - 1650. [Abstract] [Full Text] [PDF]

				D. B. Hunninghake, K. C. Maki, P. O. Kwiterovich Jr, M. H. Davidson, M. R. Dicklin, and S. D. Kafonek Incorporation of Lean Red Meat into a National Cholesterol Education Program Step I Diet: A Long-Term, Randomized Clinical Trial in Free-Living Persons with Hypercholesterolemia J. Am. Coll. Nutr., June 1, 2000; 19(3): 351 - 360. [Abstract] [Full Text] [PDF]

				C. Skoglund-Andersson, R. Tang, M. G. Bond, U. de Faire, A. Hamsten, and F. Karpe LDL Particle Size Distribution Is Associated With Carotid Intima-Media Thickness in Healthy 50-Year-Old Men Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2422 - 2430. [Abstract] [Full Text] [PDF]

				K. S. Woo, P. Chook, O. T. Raitakari, B. McQuillan, J. Z. Feng, and D. S. Celermajer Westernization of Chinese Adults and Increased Subclinical Atherosclerosis Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2487 - 2493. [Abstract] [Full Text] [PDF]

				R. Klein, L. Clegg, L. S. Cooper, L. D. Hubbard, B. E. K. Klein, W. N. King, A. R. Folsom, and for the Atherosclerosis Risk in Communities Study Prevalence of Age-related Maculopathy in the Atherosclerosis Risk in Communities Study Arch Ophthalmol, September 1, 1999; 117(9): 1203 - 1210. [Abstract] [Full Text] [PDF]

				K. Jensen-Urstad, M. Jensen-Urstad, and J. Johansson Carotid Artery Diameter Correlates With Risk Factors for Cardiovascular Disease in a Population of 55-Year-Old Subjects Stroke, August 1, 1999; 30(8): 1572 - 1576. [Abstract] [Full Text] [PDF]

				J. T. Moroney, M.-X. Tang, L. Berglund, S. Small, C. Merchant, K. Bell, Y. Stern, and R. Mayeux Low-Density Lipoprotein Cholesterol and the Risk of Dementia With Stroke JAMA, July 21, 1999; 282(3): 254 - 260. [Abstract] [Full Text] [PDF]

				M. H. Davidson, D. Hunninghake, K. C. Maki, P. O. Kwiterovich Jr, and S. Kafonek Comparison of the Effects of Lean Red Meat vs Lean White Meat on Serum Lipid Levels Among Free-living Persons With Hypercholesterolemia: A Long-term, Randomized Clinical Trial Arch Intern Med, June 28, 1999; 159(12): 1331 - 1338. [Abstract] [Full Text] [PDF]

				D. L. Rainwater, C. A. McMahan, G. T. Malcom, W. D. Scheer, P. S. Roheim, H. C. McGill Jr, and J. P. Strong Lipid and Apolipoprotein Predictors of Atherosclerosis in Youth : Apolipoprotein Concentrations Do Not Materially Improve Prediction of Arterial Lesions in PDAY Subjects Arterioscler Thromb Vasc Biol, March 1, 1999; 19(3): 753 - 761. [Abstract] [Full Text] [PDF]

				S. Soderberg, B. Ahren, B. Stegmayr, O. Johnson, P.-G. Wiklund, L. Weinehall, G. Hallmans, and T. Olsson Leptin Is a Risk Marker for First-Ever Hemorrhagic Stroke in a Population-Based Cohort Stroke, February 1, 1999; 30(2): 328 - 337. [Abstract] [Full Text] [PDF]

				S. MacMahon, N. Sharpe, G. Gamble, H. Hart, J. Scott, J. Simes, and H. White Effects of Lowering Average or Below-Average Cholesterol Levels on the Progression of Carotid Atherosclerosis : Results of the LIPID Atherosclerosis Substudy Circulation, May 19, 1998; 97(18): 1784 - 1790. [Abstract] [Full Text] [PDF]

				J. Gariepy, J. Salomon, N. Denarie, F. Laskri, J. L. Megnien, J. Levenson, and A. Simon Sex and Topographic Differences in Associations Between Large-Artery Wall Thickness and Coronary Risk Profile in a French Working Cohort : The AXA Study Arterioscler Thromb Vasc Biol, April 1, 1998; 18(4): 584 - 590. [Abstract] [Full Text] [PDF]

				P. W.F. Wilson, J. M. Hoeg, R. B. D'Agostino, H. Silbershatz, A. M. Belanger, H. Poehlmann, D. O'Leary, and P. A. Wolf Cumulative Effects of High Cholesterol Levels, High Blood Pressure, and Cigarette Smoking on Carotid Stenosis N. Engl. J. Med., August 21, 1997; 337(8): 516 - 522. [Abstract] [Full Text] [PDF]

				J. R. Crouse III, R. P. Byington, H. M. Hoen, and C. D. Furberg Reductase Inhibitor Monotherapy and Stroke Prevention Arch Intern Med, June 23, 1997; 157(12): 1305 - 1310. [Abstract] [PDF]

				L. Niskanen, R. Rauramaa, H. Miettinen, S. M. Haffner, M. Mercuri, and M. Uusitupa Carotid Artery Intima-Media Thickness in Elderly Patients With NIDDM and in Nondiabetic Subjects Stroke, November 1, 1996; 27(11): 1986 - 1992. [Abstract] [Full Text]

				K. L. Gillotte, W. S. Davidson, S. Lund-Katz, G. H. Rothblat, and M. C. Phillips Apolipoprotein A-I Structural Modification and the Functionality of Reconstituted High Density Lipoprotein Particles in Cellular Cholesterol Efflux J. Biol. Chem., September 27, 1996; 271(39): 23792 - 23798. [Abstract] [Full Text] [PDF]

				M. J. Stampfer, R. M. Krauss, J. Ma, P. J. Blanche, L. G. Holl, F. M. Sacks, and C. H. Hennekens A Prospective Study of Triglyceride Level, Low-Density Lipoprotein Particle Diameter, and Risk of Myocardial Infarction JAMA, September 18, 1996; 276(11): 882 - 888. [Abstract] [PDF]

				J. Coresh and P. O. Kwiterovich Jr Small, Dense Low-Density Lipoprotein Particles and Coronary Heart Disease Risk: A Clear Association With Uncertain Implications JAMA, September 18, 1996; 276(11): 914 - 915. [Abstract] [PDF]

				S. Tonstad, O. Joakimsen, E. Stensland-Bugge, T. P. Leren, L. Ose, D. Russell, and K. H. Bonaa Risk Factors Related to Carotid Intima-Media Thickness and Plaque in Children With Familial Hypercholesterolemia and Control Subjects Arterioscler Thromb Vasc Biol, August 1, 1996; 16(8): 984 - 991. [Abstract] [Full Text]

				A. Auperin, C. Berr, C. Bonithon-Kopp, P.-J. Touboul, I. Ruelland, P. Ducimetiere, and A. Alperovitch Ultrasonographic Assessment of Carotid Wall Characteristics and Cognitive Functions in a Community Sample of 59- to 71-Year-Olds Stroke, August 1, 1996; 27(8): 1290 - 1295. [Abstract] [Full Text]

				C. Bonithon-Kopp, P. J. Touboul, C. Berr, C. Magne, and P. Ducimetiere Factors of Carotid Arterial Enlargement in a Population Aged 59 to 71 Years : The EVA Study Stroke, April 1, 1996; 27(4): 654 - 660. [Abstract] [Full Text]

				C. Bonithon-Kopp, P.-J. Touboul, C. Berr, C. Leroux, F. Mainard, D. Courbon, and P. Ducimetiere Relation of Intima-Media Thickness to Atherosclerotic Plaques in Carotid Arteries : The Vascular Aging (EVA) Study Arterioscler Thromb Vasc Biol, February 1, 1996; 16(2): 310 - 316. [Abstract] [Full Text]

				A. R. Sharrett, L. E. Chambless, G. Heiss, C. C. Paton, and W. Patsch Association of Postprandial Triglyceride and Retinyl Palmitate Responses With Asymptomatic Carotid Artery Atherosclerosis in Middle-aged Men and Women : The Atherosclerosis Risk in Communities (ARIC) Study Arterioscler Thromb Vasc Biol, December 1, 1995; 15(12): 2122 - 2129. [Abstract] [Full Text]