Arteriosclerosis and Thrombosis, Vol 11, 1245-1249, Copyright © 1991 by American Heart Association

ARTICLES

Ultrasonographically assessed carotid morphology and the risk of coronary heart disease

JT Salonen and R Salonen
Department of Community Health and General Practice, University of Kuopio, Finland.

As ultrasonographically assessed carotid arteriosclerosis is being used as a surrogate measure for coronary arteriosclerosis, we performed a prospective longitudinal study of the association of our high- resolution ultrasound assessment of extracranial carotid morphology with the risk of acute coronary events in 1,288 eastern Finnish men. The presence of any structural changes in the common carotid arteries or carotid bulbs was associated with a 3.29-fold (95% confidence interval, 1.31-8.29; p = 0.0074), intimal-medial thickening with a 2.17- fold (95% confidence interval, 0.70-6.74; p = NS), small carotid plaques with a 4.15-fold (95% confidence interval, 1.51-11.47; p less than 0.01), and large ("stenotic") plaques with a 6.71-fold (95% confidence interval, 1.33-33.91; p less than 0.01) risk of acute myocardial infarction compared with men free of any structural changes in the carotid artery wall at baseline. These data confirm the close relation between carotid artery wall morphology and coronary heart disease.

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				E. S. Leinonen, J. T. Salonen, R. M. Salonen, R. A. Koistinen, P. J. Leinonen, S. S. Sarna, and M.-R. Taskinen Reduced IGFBP-1 Is Associated With Thickening of the Carotid Wall in Type 2 Diabetes Diabetes Care, October 1, 2002; 25(10): 1807 - 1812. [Abstract] [Full Text] [PDF]

				K. E. North, J. W. MacCluer, R. B. Devereux, B. V. Howard, T. K. Welty, L. G. Best, E. T. Lee, R. R. Fabsitz, and M. J. Roman Heritability of Carotid Artery Structure and Function: The Strong Heart Family Study Arterioscler Thromb Vasc Biol, October 1, 2002; 22(10): 1698 - 1703. [Abstract] [Full Text] [PDF]

				L. Swan and M.A. Gatzoulis Early atherosclerosis ...what does it mean? Eur. Heart J., September 1, 2002; 23(17): 1317 - 1319. [Full Text] [PDF]

				F. M. Raso, N. M. van Popele, M. A. D. H. Schalekamp, and T. J. M. van der Cammen Intima-Media Thickness of the Common Carotid Arteries Is Related to Coronary Atherosclerosis and left Ventricular Hypertrophy in Older Adults Angiology, September 1, 2002; 53(5): 569 - 574. [Abstract] [PDF]

				N. Mitsuhashi, T. Onuma, S. Kubo, N. Takayanagi, M. Honda, and R. Kawamori Coronary Artery Disease and Carotid Artery Intima-Media Thickness in Japanese Type 2 Diabetic Patients Diabetes Care, August 1, 2002; 25(8): 1308 - 1312. [Abstract] [Full Text] [PDF]

				A. Iglesias del Sol, M.L. Bots, D.E. Grobbee, A. Hofman, and J.C.M. Witteman Carotid intima-media thickness at different sites: relation to incident myocardial infarction. The Rotterdam Study Eur. Heart J., June 2, 2002; 23(12): 934 - 940. [Abstract] [Full Text] [PDF]

				L. Jartti, T. Ronnemaa, J. Kaprio, M.J. Jarvisalo, J.O. Toikka, J. Marniemi, N. Hammar, L. Alfredsson, M. Saraste, J. Hartiala, et al. Population-Based Twin Study of the Effects of Migration From Finland to Sweden on Endothelial Function and Intima-Media Thickness Arterioscler Thromb Vasc Biol, May 1, 2002; 22(5): 832 - 837. [Abstract] [Full Text] [PDF]

				P R J Ames, A Margarita, J D. Alves, C Tommasino, L Iannaccone, and V Brancaccio Anticardiolipin antibody titre and plasma homocysteine level independently predict intima media thickness of carotid arteries in subjects with idiopathic antiphospholipid antibodies Lupus, April 1, 2002; 11(4): 208 - 214. [Abstract] [PDF]

				W. Takashi, F. Tsutomu, and F. Kentaro Ultrasonic Correlates of Common Carotid Atherosclerosis in Patients with Coronary Artery Disease Angiology, March 1, 2002; 53(2): 177 - 183. [Abstract] [PDF]

				L.M. Cupini, P. Pasqualetti, M. Diomedi, F. Vernieri, M. Silvestrini, B. Rizzato, F. Ferrante, and G. Bernardi Carotid Artery Intima-Media Thickness and Lacunar Versus Nonlacunar Infarcts Stroke, March 1, 2002; 33(3): 689 - 694. [Abstract] [Full Text] [PDF]

				S. Stork, K. Baumann, C. von Schacky, and P. Angerer The effect of 17{beta}-estradiol on MCP-1 serum levels in postmenopausal women Cardiovasc Res, February 15, 2002; 53(3): 642 - 649. [Abstract] [Full Text] [PDF]

				K. Karnicki, E. Komorowicz, D. N. Fass, W. G. Owen, and R. D. McBane II Influence of Anatomical Location on Arterial Thrombosis Arterioscler Thromb Vasc Biol, February 1, 2002; 22(2): 342 - 347. [Abstract] [Full Text] [PDF]

				L. E. Chambless, A. R. Folsom, V. Davis, R. Sharrett, G. Heiss, P. Sorlie, M. Szklo, G. Howard, and G. W. Evans Risk Factors for Progression of Common Carotid Atherosclerosis: The Atherosclerosis Risk in Communities Study, 1987-1998 Am. J. Epidemiol., January 1, 2002; 155(1): 38 - 47. [Abstract] [Full Text] [PDF]

				M. J. Jarvisalo, L. Jartti, K. Nanto-Salonen, K. Irjala, T. Ronnemaa, J. J. Hartiala, D. S. Celermajer, and O. T. Raitakari Increased Aortic Intima-Media Thickness: A Marker of Preclinical Atherosclerosis in High-Risk Children Circulation, December 11, 2001; 104(24): 2943 - 2947. [Abstract] [Full Text] [PDF]

				R. Blackburn, P. Giral, E. Bruckert, J.-M. Andre, S. Gonbert, M. Bernard, M. J. Chapman, and G. Turpin Elevated C-Reactive Protein Constitutes an Independent Predictor of Advanced Carotid Plaques in Dyslipidemic Subjects Arterioscler Thromb Vasc Biol, December 1, 2001; 21(12): 1962 - 1968. [Abstract] [Full Text] [PDF]

				J. D. Beck, J. R. Elter, G. Heiss, D. Couper, S. M. Mauriello, and S. Offenbacher Relationship of Periodontal Disease to Carotid Artery Intima-Media Wall Thickness: The Atherosclerosis Risk in Communities (ARIC) Study Arterioscler Thromb Vasc Biol, November 1, 2001; 21(11): 1816 - 1822. [Abstract] [Full Text] [PDF]

				P. Amarenco Hypercholesterolemia, lipid-lowering agents, and the risk for brain infarction Neurology, September 1, 2001; 57(90002): S35 - 44. [Abstract] [Full Text]

				T. Mannami, T. Katsuya, S. Baba, N. Inamoto, K. Ishikawa, J. Higaki, T. Ogihara, and J. Ogata Low Potentiality of Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism as a Useful Predictive Marker for Carotid Atherogenesis in a Large General Population of a Japanese City : The Suita Study Stroke, June 1, 2001; 32(6): 1250 - 1256. [Abstract] [Full Text] [PDF]