Arteriosclerosis, Vol 10, 379-385, Copyright © 1990 by American Heart Association

ARTICLES

Phenotypic effects of apolipoprotein structural variation on lipid profiles. III. Contribution of apolipoprotein E phenotype to prediction of total cholesterol, apolipoprotein B, and low density lipoprotein cholesterol in the healthy women study

JE Eichner, LH Kuller, RE Ferrell, EN Meilahn and MI Kamboh
Department of Epidemiology, School of Public Health, University of Pittsburgh, Pennsylvania 15261.

The apolipoprotein (apo) E structural locus has been shown to influence concentrations of total cholesterol, apo B, and low density lipoprotein (LDL) cholesterol in population studies. Apo E has six phenotypes resulting from three common alleles at this locus. In the present study, we have typed 473 healthy white women for apo E. At baseline in 1984, all women were premenopausal. To date, 109 of these women have become postmenopausal and are not on hormone therapy. Statistical analyses were done on both pre- and postmenopausal groups to assess the influence of menopausal status in combination with the apo E locus on lipid profile. Nine lipoprotein lipids and apolipoproteins were categorized by three apo E phenotypes: apo E3-2, apo E3-3, and apo E4- 3. These were compared in analysis of variance. At baseline, the apo E3- 2 phenotype showed the lowest average concentrations of total cholesterol (170 mg/dl), apo B (80 mg/dl), and LDL cholesterol (91 mg/dl), while the apo E4-3 phenotype demonstrated the highest average concentrations of total cholesterol (192 mg/dl), apo B (104 mg/dl), and LDL cholesterol (116 mg/dl) (p less than or equal to 0.0004). Apo E3-3 homozygotes were intermediate on all three quantitative variables. The postmenopausal subset showed the same trends by phenotype, with overall increases in total cholesterol, apo B, LDL cholesterol, and triglycerides, regardless of phenotype. Women who remained premenopausal generally showed smaller increases in these same measures. Our results suggest that, on average, the lower lipoprotein values for the apo E3-2 phenotype are maintained through early menopause despite a worsening of lipid profiles for all women as they age.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				G. Kolovou, D. Damaskos, K. Anagnostopoulou, and D. V. Cokkinos Apolipoprotein E Gene Polymorphism and Gender Ann. Clin. Lab. Sci., January 1, 2009; 39(2): 120 - 133. [Abstract] [Full Text] [PDF]

				D. Corella, K. Tucker, C. Lahoz, O. Coltell, L A. Cupples, P. W. Wilson, E. J Schaefer, and J. M Ordovas Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study Am. J. Clinical Nutrition, April 1, 2001; 73(4): 736 - 745. [Abstract] [Full Text] [PDF]

				M. F. Newman, D. T. Laskowitz, W. D. White, J. L. Kirchner, H. P. Grocott, M. Stafford-Smith, M. H. Sketch, R. H. Jones, J. G. Reves, and A. M. Saunders Apolipoprotein E Polymorphisms and Age at First Coronary Artery Bypass Graft Anesth. Analg., April 1, 2001; 92(4): 824 - 829. [Abstract] [Full Text] [PDF]

				A. Batalla, R. Alvarez, J. R. Reguero, S. Hevia, G. Iglesias-Cubero, V. Alvarez, A. Cortina, P. Gonzalez, M. M. Celada, A. Medina, et al. Synergistic Effect between Apolipoprotein E and Angiotensinogen Gene Polymorphisms in the Risk for Early Myocardial Infarction Clin. Chem., December 1, 2000; 46(12): 1910 - 1915. [Abstract] [Full Text] [PDF]

				M. F. Newman, T. O. Stanley, and H. P. Grocott Strategies to Protect the Brain During Cardiac Surgery Seminars in Cardiothoracic and Vascular Anesthesia, July 1, 2000; 4(2): 53 - 64. [Abstract] [PDF]

				M. F. Newman, D. T. Laskowitz, A. M. Saunders, A. M. Grigore, and H. P. Grocott Genetic Predictors of Perioperative Neurologic and Neuropsychological Injury and Recovery Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 1999; 3(1): 34 - 46. [Abstract] [PDF]

				M. M. Zaman, S. Ikemoto, N. Yoshiike, C. Date, T. Yokoyama, and H. Tanaka Association of Apolipoprotein Genetic Polymorphisms With Plasma Cholesterol in a Japanese Rural Population : The Shibata Study Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3495 - 3504. [Abstract] [Full Text]

				P. W.F. Wilson, E. J. Schaefer, M. G. Larson, and J. M. Ordovas Apolipoprotein E Alleles and Risk of Coronary Disease: A Meta-analysis Arterioscler Thromb Vasc Biol, October 1, 1996; 16(10): 1250 - 1255. [Abstract] [Full Text]

				P. W. F. Wilson, R. H. Myers, M. G. Larson, J. M. Ordovas, P. A. Wolf, and E. J. Schaefer Apolipoprotein E Alleles, Dyslipidemia, and Coronary Heart Disease: The Framingham Offspring Study JAMA, December 7, 1994; 272(21): 1666 - 1671. [Abstract] [PDF]