on November 30, 2006
Published online before print November 30, 2006, doi: 10.1161/01.ATV.0000253907.51681.0e
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Submitted on April 20, 2006
Accepted on November 15, 2006
In Vivo Plaque Characterization Using Intravascular Ultrasound-Virtual Histology in a Porcine Model of Complex Coronary Lesions
Juan F. Granada *;
From The Methodist Hospital Research Institute & The Methodist DeBakey Heart Center (J.F.G., D.G.S., A.E.R., G.L.K.), Houston, Tex; Department of Mathematics (D.W.-B.), University of Houston, Houston, Tex; Baylor College of Medicine (H.K.W.), Houston, Tex; The Corbic Research Foundation-HMUA (C.L.A.), Envigado, Colombia; Instituto de Ciencias de la Salud (A.B.), Medellin, Colombia; Department of Pathology (R.B.), The Methodist Hospital, Houston, Tex.
* To whom correspondence should be addressed. E-mail: jgranada{at}tmh.tmc.edu.
Objective--To determine the accuracy of detection of different tissue types of intravascular ultrasound-virtual histology (IVUS-VH) in a porcine model of complex coronary lesions.
Methods and Results--Coronary lesions were induced by injecting liposomes containing human oxidized low-density lipoprotein into the adventitia of the arteries. IVUS-VH imaging was performed in vivo at 8.2±1.6 weeks after injection. A total of 60 vascular lesions were analyzed and compared with their correspondent IVUS-VH images. Correlation analysis was performed using linear regression models. Compared with histology, IVUS-VH correctly identified the presence of fibrous, fibro-fatty, and necrotic tissue in 58.33%, 38.33%, and 38.33% of lesions, respectively. The sensitivity of IVUS-VH for the detection of fibrous, fibro-fatty, and necrotic core tissue was 76.1%, 46%, and 41.1% respectively. A linear regression analysis performed for each individual plaque component did not show strong correlation that would allow significant prediction of individual values.
Conclusions--In a porcine model of complex coronary lesions, IVUS-VH was not accurate in detecting the relative amount of specific plaque components within each individual corresponding histological specimen.
Key words: animal model • intravascular ultrasound • vulnerable plaque
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