on August 10, 2006
Published online before print August 10, 2006, doi: 10.1161/01.ATV.0000240517.69201.77
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Submitted on April 6, 2006
Accepted on July 9, 2006
Serum Levels of Mannose-Binding Lectin and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women
Tymen T. Keller *;
From the Departments of Vascular Medicine (T.T.K., S.I.v.L., M.C.M., E.S.S., M.L.) and Cardiology (S.M.B.), Academic Medical Center, Amsterdam, The Netherlands; Medical Research Council Epidemiology Unit (N.J.W.), Cambridge, United Kingdom; Department of Public Health and Primary Care (R.L., K.T.K.), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom; Department of Clinical Chemistry (E.H.), VU Medical Center, Amsterdam, The Netherlands.
* To whom correspondence should be addressed. E-mail: t.t.keller{at}amc.uva.nl.
Objective--To determine the association between serum levels of mannose-binding lectin (MBL) and the risk of future coronary artery disease (CAD) in apparently healthy men and women.
Methods and Results--We performed a prospective case-control study among apparently healthy men and women nested in the EPIC-Norfolk cohort. Baseline concentrations of MBL were measured in serum samples of 946 patients who experienced a myocardial infarction or died of CAD during follow-up, and 1799 matched controls who remained free of CAD. Among men, median MBL levels were 1.63 ng/mL (interquartile range [IQR]: 0.59 to 3.80) in cases and 1.20 ng/mL (IQR: 0.48 to 3.37) in controls. Among women, median MBL levels were 1.02 ng/mL (IQR: 0.43 to 2.95) in cases and 1.01 ng/mL (IQR: 0.43 to 2.94) in controls. After adjustment, the odds ratio in men for future CAD was 1.59 (95% confidence interval [CI]: 1.09 to 2.32; P for linearity=0.01) for those in the highest quartile compared with those in the lowest quartile. In women no such relation was observed.
Conclusions--Elevated levels of MBL are associated with an increased risk of future CAD in apparently healthy men but not in women. The sex difference merits further exploration.
Key words: atherosclerosis • coronary artery disease • inflammation • mannose-binding lectin
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