on July 6, 2006
Published online before print July 6, 2006, doi: 10.1161/01.ATV.0000235691.84430.86
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Submitted on March 10, 2006
Accepted on June 2, 2006
Chemokines and Incident Coronary Heart Disease. Results From the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002
Christian Herder ;
From the German Diabetes Clinic (C.H., S.M., H.K.), German Diabetes Center, Leibniz Center at Heinrich Heine University, Düsseldorf; GSF-National Research Center for Environment and Health (J.B., B.T., H.L.), Institute of Epidemiology, Neuherberg; and Department of Internal Medicine II-Cardiology (W.K.), University of Ulm Medical Center, Germany.
* To whom correspondence should be addressed. E-mail: thorand{at}gsf.de.
Objectives--The chemokines monocyte chemoattractant protein-1 (MCP-1/CCL2), interleukin (IL-8/CXCL8), and interferon-
-inducible protein-10 (IP-10/CXCL10) have been reported to be involved in the development of atherosclerosis and type 2 diabetes. The aim of this study was to assess whether elevated systemic levels of these chemokines precede coronary events.
Methods and Results--We investigated MCP-1, IL-8, and IP-10 serum levels in a case-cohort design based on data from 381 individuals (294 men, 87 women) with and 1977 individuals (1006 men, 971 women) without incident coronary heart disease (CHD) from the prospective, population-based MONICA/KORA Augsburg study (1984 to 2002). The mean follow-up time was 11.0 years. Baseline concentrations were significantly higher in cases compared with noncases (P
0.001 for all chemokines). MCP-1 and IL-8 remained associated with CHD risk after adjustment for age, sex, and survey with hazard ratios (95% confidence intervals) comparing extreme tertiles of 1.39 (1.05 to 1.84) for MCP-1 and 1.48 (1.10 to 1.99) for IL-8. However, adjustment for further cardiovascular and immunologic risk factors attenuated the observed associations, and they became nonsignificant.
Conclusions--Elevated systemic levels of the chemokines MCP-1, IL-8, and IP-10 precede CHD but do not represent independent risk factors. Thus, the associations are less pronounced than previously shown for type 2 diabetes.
Key words: chemokines • inflammation • coronary heart disease • case-cohort study • prognosis
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