on May 18, 2006
Arteriosclerosis, Thrombosis, and Vascular Biology. 2006
Published online before print May 18, 2006, doi: 10.1161/01.ATV.0000227513.13697.ac
Published online before print May 18, 2006, doi: 10.1161/01.ATV.0000227513.13697.ac
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on October 28, 2005
Accepted on May 8, 2006
Pathogenesis of Calcific Aortic Valve Disease. A Disease Process Comes of Age (and a Good Deal More)
Kevin D. O’Brien *
From the Division of Cardiology, University of Washington, Seattle.
* To whom correspondence should be addressed. E-mail: cardiac{at}u.washington.edu.
Background--Over the past 10 to 15 years, calcific aortic valve disease, which includes aortic sclerosis and aortic stenosis, has come to be recognized as an active process, based on: (1) epidemiologic studies demonstrating associations of specific risk factors with increased prevalence or rate of progression of aortic valve disease; (2) identification, in valve lesions, of histopathologic features of chronic inflammation, lipoprotein deposition, renin-angiotensin system components, and molecular mediators of calcification; and (3) identification of cell-signaling pathways and genetic factors that may participate in valve disease pathogenesis. These studies will be reviewed and organized into a proposed global hypothesis for the pathogenesis of calcific aortic valve disease.
This article has been cited by other articles:
 |
|
 |
|
  Y. Bosse, A. Miqdad, D. Fournier, A. Pepin, P. Pibarot, and P. Mathieu Refining Molecular Pathways Leading to Calcific Aortic Valve Stenosis by Studying Gene Expression Profile of Normal and Calcified Stenotic Human Aortic Valves Circ Cardiovasc Genet, October 1, 2009; 2(5): 489 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Dumesnil, P. Pibarot, and B. Carabello Paradoxical low flow and/or low gradient severe aortic stenosis despite preserved left ventricular ejection fraction: implications for diagnosis and treatment Eur. Heart J., September 8, 2009; (2009) ehp361v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Barrick, R. B. Roberts, M. Rojas, N. M. Rajamannan, C. B. Suitt, K. D. O'Brien, S. S. Smyth, and D. W. Threadgill Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H65 - H75. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Y. Y. Yip, J.-H. Chen, R. Zhao, and C. A. Simmons Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix Arterioscler Thromb Vasc Biol, June 1, 2009; 29(6): 936 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Gu and K. S. Masters Role of the MAPK/ERK pathway in valvular interstitial cell calcification Am J Physiol Heart Circ Physiol, June 1, 2009; 296(6): H1748 - H1757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Balachandran, P. Sucosky, H. Jo, and A. P. Yoganathan Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H756 - H764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Chen, C. Y. Y. Yip, E. D. Sone, and C. A. Simmons Identification and Characterization of Aortic Valve Mesenchymal Progenitor Cells with Robust Osteogenic Calcification Potential Am. J. Pathol., March 1, 2009; 174(3): 1109 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yang, D. A. Fullerton, X. Su, L. Ao, J. C. Cleveland Jr, and X. Meng Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2. J. Am. Coll. Cardiol., February 10, 2009; 53(6): 491 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rattazzi, L. Iop, E. Faggin, E. Bertacco, G. Zoppellaro, I. Baesso, M. Puato, G. Torregrossa, G. P. Fadini, C. Agostini, et al. Clones of Interstitial Cells From Bovine Aortic Valve Exhibit Different Calcifying Potential When Exposed to Endotoxin and Phosphate Arterioscler Thromb Vasc Biol, December 1, 2008; 28(12): 2165 - 2172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Liu and A. I. Gotlieb Transforming Growth Factor-{beta} Regulates in Vitro Heart Valve Repair by Activated Valve Interstitial Cells Am. J. Pathol., November 1, 2008; 173(5): 1275 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Towler Oxidation, Inflammation, and Aortic Valve Calcification: Peroxide Paves an Osteogenic Path J. Am. Coll. Cardiol., September 2, 2008; 52(10): 851 - 854. [Full Text] [PDF]
|
|
|
|
 |
|
 C Cote, P Pibarot, J-P Despres, D Mohty, A Cartier, B J Arsenault, C Couture, and P Mathieu Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis Heart, September 1, 2008; 94(9): 1175 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Toutouzas, M. Drakopoulou, A. Synetos, E. Tsiamis, G. Agrogiannis, N. Kavantzas, E. Patsouris, D. Iliopoulos, S. Theodoropoulos, M. Yacoub, et al. In Vivo Aortic Valve Thermal Heterogeneity in Patients With Nonrheumatic Aortic Valve Stenosis: The First In Vivo Experience in Humans J. Am. Coll. Cardiol., August 26, 2008; 52(9): 758 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Greve and K. Wachtell Review: Does lowering cholesterol have an impact on the progression of aortic stenosis? Therapeutic Advances in Cardiovascular Disease, August 1, 2008; 2(4): 277 - 286. [Abstract] [PDF]
|
|
|
|
 |
|
 L. L. Demer and Y. Tintut Vascular Calcification: Pathobiology of a Multifaceted Disease Circulation, June 3, 2008; 117(22): 2938 - 2948. [Full Text] [PDF]
|
|
|
|
|
|
Y. Bosse, P. Mathieu, and P. Pibarot Genomics: The Next Step to Elucidate the Etiology of Calcific Aortic Valve Stenosis J. Am. Coll. Cardiol., April 8, 2008; 51(14): 1327 - 1336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Goldbarg, S. Elmariah, M. A. Miller, and V. Fuster Reply J. Am. Coll. Cardiol., April 8, 2008; 51(14): 1416 - 1416. [Full Text] [PDF]
|
|
|
|
|
|
Z. Awan, K. Alrasadi, G.A. Francis, R.A. Hegele, R. McPherson, J. Frohlich, D. Valenti, B. de Varennes, M. Marcil, C. Gagne, et al. Vascular Calcifications in Homozygote Familial Hypercholesterolemia Arterioscler Thromb Vasc Biol, April 1, 2008; 28(4): 777 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Towler Vascular Calcification: A Perspective On An Imminent Disease Epidemic IBMS BoneKEy, February 1, 2008; 5(2): 41 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Padera Jr. and F. J. Schoen Pathology of Cardiac Surgery Card. Surg. Adult, January 1, 2008; 3(2008): 111 - 178. [Full Text]
|
|
|
|
|
|
D. Mohty, P. Pibarot, J.-P. Despres, C. Cote, B. Arsenault, A. Cartier, P. Cosnay, C. Couture, and P. Mathieu Association Between Plasma LDL Particle Size, Valvular Accumulation of Oxidized LDL, and Inflammation in Patients With Aortic Stenosis Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 187 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Stone C-Reactive Protein to Identify Early Risk for Development of Calcific Aortic Stenosis: Right Marker? Wrong Time? J. Am. Coll. Cardiol., November 13, 2007; 50(20): 1999 - 2001. [Full Text] [PDF]
|
|
|
|
|
|
A. C. Liu, V. R. Joag, and A. I. Gotlieb The Emerging Role of Valve Interstitial Cell Phenotypes in Regulating Heart Valve Pathobiology Am. J. Pathol., November 1, 2007; 171(5): 1407 - 1418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.J. Grande-Allen, N. Osman, M.L. Ballinger, H. Dadlani, S. Marasco, and P.J. Little Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease Cardiovasc Res, October 1, 2007; 76(1): 19 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Goldbarg, S. Elmariah, M. A. Miller, and V. Fuster Insights Into Degenerative Aortic Valve Disease J. Am. Coll. Cardiol., September 25, 2007; 50(13): 1205 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. O. Peltonen, P. Taskinen, Y. Soini, J. Rysa, J. Ronkainen, P. Ohtonen, J. Satta, T. Juvonen, H. Ruskoaho, and H. Leskinen Distinct Downregulation of C-Type Natriuretic Peptide System in Human Aortic Valve Stenosis Circulation, September 11, 2007; 116(11): 1283 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Arishiro, M. Hoshiga, N. Negoro, D. Jin, S. Takai, M. Miyazaki, T. Ishihara, and T. Hanafusa Angiotensin Receptor-1 Blocker Inhibits Atherosclerotic Changes and Endothelial Disruption of the Aortic Valve in Hypercholesterolemic Rabbits J. Am. Coll. Cardiol., April 3, 2007; 49(13): 1482 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Towler Imaging Aortic Matrix Metabolism: Mirabile Visu! Circulation, January 23, 2007; 115(3): 297 - 299. [Full Text] [PDF]
|
|
|
|
|
|
E. Aikawa, M. Nahrendorf, D. Sosnovik, V. M. Lok, F. A. Jaffer, M. Aikawa, and R. Weissleder Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease Circulation, January 23, 2007; 115(3): 377 - 386. [Abstract] [Full Text] [PDF]
|
|