on March 30, 2006
Published online before print March 30, 2006, doi: 10.1161/01.ATV.0000219611.50066.bd
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on November 28, 2005
Accepted on March 16, 2006
Adiponectin Is an Important Determinant of ApoA-I Catabolism
Bruno Vergès *;
From Service Endocrinologie (B.V., J.M.P., F.G.), Diabétologie et Maladies Métaboliques, Centre Hospitalier Universitaire de Dijon, France; INSERM U 498 (B.V., J.M.P., L.D., G.D., E.F., P.G.), Faculté de Médecine, Dijon, France.
* To whom correspondence should be addressed. E-mail: bruno.verges{at}chu-dijon.fr.
Objective--Plasma concentration of adiponectin is positively correlated with high-density lipoprotein (HDL) cholesterol level. However, the role of adiponectin on HDL metabolism remains unknown. This prompted us to perform an in vivo kinetic study of apoA-I, the main apolipoprotein of HDL, using stable isotopes, in 22 subjects with a wide range of plasma adiponectin, including 11 patients with metabolic syndrome (8 with type 2 diabetes, 3 without type 2 diabetes) and 11 normal individuals.
Methods and Results--In the 22 studied subjects, plasma adiponectin levels ranged from 2.57 to 14.44 µg/mL and apoA-I fractional catabolic rate (FCR) values ranged from 0.142 to 0.340 day-1. A strong negative correlation was found between adiponectin and apoA-I FCR (r=-0.66, P<0.001) in the whole studied population and, to a similar extent, in patients with metabolic syndrome (r=-0.73, P=0.010) and normal subjects (r=-0.68, P=0.020), separately. In multivariable analysis, apoA-I FCR was associated negatively with adiponectin (P=0.005) and positively with HDL triglycerides/cholesterol ratio (P=0.006), but not with age, sex, body mass index (BMI), waist circumference, plasma triglycerides, HDL cholesterol, fasting glycemia, and QUICKI. Both adiponectin and HDL triglycerides/cholesterol ratio explained 62% of the variance of apoA-I FCR and adiponectin on its own explained 43%.
Conclusions--Our kinetic study shows a strong negative correlation between adiponectin and apoA-I FCR, which can explain the positive link between HDL cholesterol and adiponectin. This association is independent of obesity, insulin resistance, and the content of triglycerides within HDL particles. These data suggest that adiponectin may have a direct role on HDL catabolism.
Key words: adiponectin • apoA-I • HDL cholesterol • insulin-resistance • kinetic
This article has been cited by other articles:
 |
|
 |
|
  B. Verges, E. Florentin, S. Baillot-Rudoni, J.-M. Petit, M. C. Brindisi, J.-P. Pais de Barros, L. Lagrost, P. Gambert, and L. Duvillard Rosuvastatin 20 mg restores normal HDL-apoA-I kinetics in type 2 diabetes J. Lipid Res., June 1, 2009; 50(6): 1209 - 1215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Chan, P. H. R. Barrett, E. M. M. Ooi, J. Ji, D. T. Chan, and G. F. Watts Very Low Density Lipoprotein Metabolism and Plasma Adiponectin as Predictors of High-Density Lipoprotein Apolipoprotein A-I Kinetics in Obese and Nonobese Men J. Clin. Endocrinol. Metab., March 1, 2009; 94(3): 989 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Qiao, C. Zou, D. R. van der Westhuyzen, and J. Shao Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism Diabetes, July 1, 2008; 57(7): 1824 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P F Dullaart, A. K Groen, G. M Dallinga-Thie, R. de Vries, W. J Sluiter, and A. van Tol Fibroblast cholesterol efflux to plasma from metabolic syndrome subjects is not defective despite low high-density lipoprotein cholesterol Eur. J. Endocrinol., January 1, 2008; 158(1): 53 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P F Dullaart, R. de Vries, A. van Tol, and W. J Sluiter Lower plasma adiponectin is a marker of increased intima-media thickness associated with type 2 diabetes mellitus and with male gender Eur. J. Endocrinol., March 1, 2007; 156(3): 387 - 394. [Abstract] [Full Text] [PDF]
|
|