on February 9, 2006
Published online before print February 9, 2006, doi: 10.1161/01.ATV.0000209577.04246.c0
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Submitted on September 30, 2005
Accepted on January 26, 2006
Decreased High-Density Lipoprotein (HDL) Particle Size, Pre
-, and Large HDL Subspecies Concentration in Finnish Low-HDL Families. Relationship With Intima-Media Thickness
Hiroshi Watanabe ;
From the Division of Cardiology (H.W., S.S., A.S.-P., A.H., E.L., C.A., M.-R.T.), Department of Medicine, University of Helsinki and Biomedicum, Finland; Unita Operativa di Medicina Interna (C.A.), Ospedale Cannizzaro, Universitá di Catania, Catania, Italy; Research Institute of Public Health (R.S., T.-P.T.), University of Kuopio, Finland; and Department of Molecular Medicine (C.E., M.J.), Biomedicum, National Public Health Institute, Helsinki, Finland.
* To whom correspondence should be addressed. E-mail: marja-riitta.taskinen{at}helsinki.fi.
Objective--High-density lipoprotein (HDL) cholesterol correlates inversely with the risk of coronary heart disease (CHD). The precise antiatherogenic mechanisms of HDL subspecies are not thoroughly elucidated. We studied the relationship between carotid intima-media thickness (IMT) and HDL subspecies distribution in Finnish families with low HDL cholesterol and premature CHD.
Methods and Results--Altogether, 148 members of Finnish low-HDL families and 133 healthy control subjects participated in our study. HDL particle size was significantly smaller in affected family members (HDL 
10th Finnish age-sex specific percentile) compared with unaffected family members and control subjects (9.1±0.04 nm versus 9.5±0.05 nm, P<0.0001, versus 9.8±0.03 nm, P<0.0001 [mean±SE]). Large HDL2b and HDL2a particles as well as pre
-HDL concentration were significantly decreased among the affected family members. Mean IMT was significantly higher in the affected family members than in the control subjects (0.85±0.01 mm versus 0.79±0.01 mm; P<0.0001). Age, HDL2b, systolic blood pressure, and pre-HDL were significant independent determinants of mean IMT.
Conclusions--The decreased levels of HDL2b and pre-HDL reflect the potentially efflux-deficient HDL subspecies profile in the affected low-HDL family members. Decreased HDL particle size caused by the decrease of plasma concentration of HDL2b and decreased pre-HDL levels correlate with increased IMT.
Key words: HDL particle size • HDL subspecies • pre
-HDL •
intima-media thickness •
atherosclerosis
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